DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppr-Y and LRRC56

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_932341.1	Gene:	LRRC56 / 115399	HGNCID:	25430	Length:	542	Species:	Homo sapiens

Alignment Length:	165	Identity:	41/165 - (24%)
Similarity:	65/165 - (39%)	Gaps:	52/165 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RGEGRRLHQL-EPVVLEQILTMRLEFNNILRIDHLWI---------------------LPNLTKL 86
            :|.|.:..:| |.:|.|.:...||:  .:.|:|.|.:                     ||||.:|
Human    36 KGPGSQRDRLGEQLVEEYLSPARLQ--ALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQL 98

  Fly    87 CLN------------------------CNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNL 127
            .||                        |. :..::.|..|..||:|..|:|.|..:..|..|..|
Human    99 KLNGSHLGSLRDLGTSLGHLQVLWLARCG-LADLDGIASLPALKELYASYNNISDLSPLCLLEQL 162

  Fly   128 EVLSLFSNKIEAIENIDMLTM---LVIISLGNNLI 159
            |||.|..|.:|.:..:..|.:   |.:::|..||:
Human   163 EVLDLEGNSVEDLGQVRYLQLCPRLAMLTLEGNLV 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	6/39 (15%)
		LRR_8	81..137	CDD:290566	23/79 (29%)
		LRR_4	81..121	CDD:289563	15/63 (24%)
		leucine-rich repeat	83..104	CDD:275378	7/44 (16%)
		LRR_4	103..143	CDD:289563	15/39 (38%)
		leucine-rich repeat	105..126	CDD:275378	8/20 (40%)
		LRR_8	126..184	CDD:290566	12/37 (32%)
		LRR_4	126..166	CDD:289563	12/37 (32%)
		leucine-rich repeat	127..148	CDD:275378	8/20 (40%)
		leucine-rich repeat	149..162	CDD:275378	4/11 (36%)
LRRC56	NP_932341.1	LRR_RI	<54..186	CDD:238064	31/134 (23%)
		LRR 1	94..115		5/20 (25%)
		leucine-rich repeat	95..117	CDD:275380	4/21 (19%)
		LRR_8	117..170	CDD:290566	16/53 (30%)
		LRR_4	117..156	CDD:289563	9/39 (23%)
		LRR 2	117..138		2/21 (10%)
		leucine-rich repeat	118..139	CDD:275380	3/21 (14%)
		LRR_4	138..175	CDD:289563	15/36 (42%)
		LRR 3	139..160		7/20 (35%)
		leucine-rich repeat	140..161	CDD:275380	8/20 (40%)
		LRR 4	161..182		7/20 (35%)
		leucine-rich repeat	162..186	CDD:275380	8/23 (35%)
		LRR 5	186..206		4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..377
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910