DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ppr-Y and drc3

DIOPT Version :9

Sequence 1:	NP_001015502.3	Gene:	Ppr-Y / 3355180	FlyBaseID:	FBgn0046697	Length:	569	Species:	Drosophila melanogaster
Sequence 2:	NP_001123832.1	Gene:	drc3 / 100170587	XenbaseID:	XB-GENE-1003585	Length:	522	Species:	Xenopus tropicalis

Alignment Length:	537	Identity:	162/537 - (30%)
Similarity:	294/537 - (54%)	Gaps:	25/537 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IYPDIEPGIINRSLIESSYLKHVHRGEGRRLHQLEPVVLEQILTMRLEFNNILRIDHLWILPNLT 84
            :|..:||.:|:..::.::..:...:.|..|:.:||.:..:.:.::||:|.|||:||:||...:||
Frog     4 LYDTMEPNVIDDDMLRNAVEEQGPKEEAGRIAKLEGIDFKHVSSLRLDFKNILKIDNLWQFHSLT 68

  Fly    85 KLCLNCNKIETIENIEMLTNLKDLNLSFNFIEKIENLDTLVNLEVLSLFSNKIEAIENIDMLTML 149
            ||.|:.|.||.|..::.|.:|..|:||||.||.||.|..|..||.|||::|:|..:||:|.|:.|
Frog    69 KLQLDNNIIEKISGLDTLVHLVWLDLSFNNIEVIEGLKALTKLEDLSLYNNRISVVENMDTLSNL 133

  Fly   150 VIISLGNNLIDTVEGIERFRFMNNLKIINLEGNPIAKRTNFCLLKYISAILPKLNYYEYTFIKSE 214
            .::|||||.:.::|.:...|....|:.::|.|||:::...:.|  :|:|.||.|.|.::..:...
Frog   134 QVLSLGNNNLTSLENLIYLRKFKQLRTLSLAGNPLSEDDQYKL--FIAAHLPNLAYLDFRLLNEN 196

  Fly   215 LRAEACNLYYREIREIEDKQEKEIQARKFLEREQSEAKRLASSFVEHLDGHQLFDSLWRGDEDGR 279
            :|..|...|...|.:|...:.:|.:.::..|::|.|.....:::||:|:|..||:|::..|.||.
Frog   197 IREMATMKYQYSIDDITHNENQEKRKQEEEEQKQRELDLHKAAYVENLNGPFLFESMYADDADGT 261

  Fly   280 VLM-LVGTQAQELADEYDKDIFELTQEIYKLGLERFTERDEEIRDFFNNLFDGQEELQILGQNEI 343
            .|. |.|  ..||.|.|.....|:.|.|::.|:::..:|:.|..:|...:.:...|.|..|..:|
Frog   262 KLSGLPG--VAELMDSYRSKCIEICQNIFEYGMKQHEKREAEAFEFNECMQEAIRENQEQGAKKI 324

  Fly   344 EWFLQFREIIFEEARIRLLKLEQNSMHGEDEDTPENLKLSDALDKLNIQFEDAINDLWQALMAQE 408
            :      |:..:.:.|    |.:.|..|.          .|.||....|:.|.||.|..:||..|
Frog   325 Q------ELTEKNSEI----LNELSQSGN----------QDFLDLKISQYIDDINKLLDSLMTLE 369

  Fly   409 LYLHESIQESTINFHRKIAELMSKFVEQSQAFFVQLREITLHFSENMTEILTRFISTKFALQDFD 473
            |.|.:..:|....:.|.:::::|.|:|..|....|:|::..|..|.:.||....:......:..|
Frog   370 LQLVDQTEEIIKEYERNVSDMVSAFLETVQGLMAQVRDLENHHHEKLLEISINLLEKVLKGEMDD 434

  Fly   474 DVPIELRVCVDDRDAILNLIAGMKDYHTLRLDEREDTIATRTKEFVDNMIDQLNSNEVERHRSKI 538
            ::..::|:...|:|.::|.::...|.|.|::|.|||.:.|:...:.:|:|.::..:|::|:|::|
Frog   435 EITDDIRMIFVDKDTVINAVSASHDIHLLKIDNREDELVTKMNTWANNLIQKVQKDEIQRNRNRI 499

  Fly   539 LEINFFVEMMTDAMTSL 555
            |||..:::.:.|.:.:|
Frog   500 LEITTYIDHLRDELDNL 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ppr-Y	NP_001015502.3	leucine-rich repeat	63..82	CDD:275378	10/18 (56%)
		LRR_8	81..137	CDD:290566	28/55 (51%)
		LRR_4	81..121	CDD:289563	20/39 (51%)
		leucine-rich repeat	83..104	CDD:275378	10/20 (50%)
		LRR_4	103..143	CDD:289563	20/39 (51%)
		leucine-rich repeat	105..126	CDD:275378	12/20 (60%)
		LRR_8	126..184	CDD:290566	23/57 (40%)
		LRR_4	126..166	CDD:289563	18/39 (46%)
		leucine-rich repeat	127..148	CDD:275378	11/20 (55%)
		leucine-rich repeat	149..162	CDD:275378	6/12 (50%)
drc3	NP_001123832.1	leucine-rich repeat	47..66	CDD:275380	10/18 (56%)
		LRR_RI	<60..211	CDD:238064	59/152 (39%)
		leucine-rich repeat	67..88	CDD:275378	10/20 (50%)
		LRR_8	88..143	CDD:290566	29/54 (54%)
		leucine-rich repeat	89..110	CDD:275378	12/20 (60%)
		LRR_4	109..149	CDD:289563	18/39 (46%)
		leucine-rich repeat	111..132	CDD:275378	11/20 (55%)
		leucine-rich repeat	133..157	CDD:275378	8/23 (35%)
		leucine-rich repeat	158..169	CDD:275378	5/10 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	136	1.000	Domainoid score	I4898
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12581
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2783
OMA	1	1.010	-	-		QHG56411
OrthoDB	1	1.010	-	-		D259508at33208
OrthoFinder	1	1.000	-	-		FOG0006354
OrthoInspector	1	1.000	-	-		otm48609
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4624
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.980