DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ORY and cfap58

DIOPT Version :9

Sequence 1:	NP_001015498.5	Gene:	ORY / 3355174	FlyBaseID:	FBgn0046323	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001119542.1	Gene:	cfap58 / 779580	XenbaseID:	XB-GENE-5719803	Length:	871	Species:	Xenopus tropicalis

Alignment Length:	858	Identity:	230/858 - (26%)
Similarity:	415/858 - (48%)	Gaps:	88/858 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KKAKKANNVDENSEPQLL--FQEVIDETDVLDLNLYSDINDEFFNEANRVVQFLMEAKRHFEASR 70
            :||:::.: ||.:...|.  ||||:.|       |..|.:.|         :|.:|.::...|.:
Frog     4 EKAEQSGS-DEKAFEALERDFQEVLQE-------LAGDKSLE---------KFQIEYEKLHSALK 51

  Fly    71 IKRYSDIIFNLHRRYVDEVNDNEVLRPQILSSEKKLRLALELTSTSEEAMQKLKDLLGDAWKESD 135
             |.|.:     .:|.:.:..:   |..:|:::..|:..|::|:...:..:..||..:..|||..|
Frog    52 -KSYDN-----EKRLMAKCRE---LNAEIVANAAKVATAIKLSQEDQSTISSLKKEIEKAWKMVD 107

  Fly   136 ASALREQLVQE---KLQEVLIKCEGLADRNSGTTDDTAEFGHLAKYKNIILRERDRLAGEVVDLE 197
            |:..:||..:|   .|::.:.....|.::.:|.:.. .|...|...|..:.:|||.|..|||.|.
Frog   108 AAYEKEQRAKETVNSLKDEVKSLSKLVEQGAGMSAG-QEHSDLLSAKEELSKERDELLAEVVKLR 171

  Fly   198 KRLATNRYYSENLEYIIRNNEDAMSKMASRAKFAEGE-------RLNVESKLRALMKTMEEQKEA 255
            :.|.......:..|......|..:.:.....:..:.|       :..:|..||.| ::..|.|:.
Frog   172 ENLVKATELQQEAEKSKEEAEQGIIQFQQEIQMRQNEASRESRKKEKLEKDLRGL-QSEAEAKQL 235

  Fly   256 HGKTMMKLDIANRELSETTRKLSQKISDYDRQRVHLDKYRSEVNALNKAMHKNEDDISDLTKNQK 320
            ..|:|.:....|:   |..::|.|::.:.......:.|...:|...|..: :.|::...:..:|.
Frog   236 EIKSMQQNLTRNK---EELQRLEQQLKENKILNERVSKELEQVQMRNNKL-QQENEQQSVLNDQL 296

  Fly   321 NNEEMIKQLRLIEKEKSNAVSQLTSRLKKSIEDQNNATTRMYKLNRKVMMLNSEILRLKNNINSL 385
            ..|...|||.|  |.|.:.|:|:...:.|..:.:.....:..::..:.:.:..:...|||.|...
Frog   297 TQENQQKQLEL--KAKEDEVNQMRQEISKISKARETIQRKYRQMEEQKIEVEQQRETLKNQITGF 359

  Fly   386 EKDVLNANGRTDDIRRIKETLQRERDSLRSDIIKLNNTMADLKHDMMLKANMISSLNLDMNKLNV 450
            |:::.:|..:.:..::..|.|.||||.|..::::..|  |..|...::|.:..|..||:....:.
Frog   360 ERELESAKKQAEIDKKAVEELVRERDMLNKNLLRAAN--ATDKQQSLVKLHEQSKKNLEEEIQSY 422

  Fly   451 KLDEAYILKS---KAEKERDEMAQEMETLHERIENYQDQISLKTSQVNDLTEKLHEKQREVHSYK 512
            | :||...:.   :.|||||....|...|.:::..:.:.|.::..|:.|..:|:.|.:.::...:
Frog   423 K-EEAQKQRKIIYQLEKERDRYINEASDLTQKVLQHMEDIKVREMQIFDYKKKIAEAETKLKQQQ 486

  Fly   513 KQLESVHSEKMMLQRNL----ENTTQERDNFRILQAKSGHQIQQLTTEISANE---VKINSLNLK 570
            ...|:|.|::.:..:||    :..|:.:...:|:    .||:.||..|||:.|   ||::..:.:
Frog   487 NLYEAVRSDRNLYSKNLIEAQDEITEMKRKLKIM----NHQVDQLKEEISSKESVLVKVHLEHQR 547

  Fly   571 IEHLNNYIKELQSDLKNKENLVAALRKDMRE----------MKAKNEMLAKTISNDELKFMKMGH 625
            ||             |.||.|.|.|:|..::          .:|:.:.|.|.||..:.:.::...
Frog   548 IE-------------KEKEALKAELQKMKQQSVETKQLIDNQEAEEKKLLKIISEADAERLRQKK 599

  Fly   626 ELEEMRKERNLVGLQMVRRNDEIVVIKEKLQIAQNALDNGTTQYNQRVEDIRLLKKEISNLHTES 690
            |||::..||:::|.|:||||||:.::.||::|.|:.|:.|..||.||||||||||.||..|..|.
Frog   600 ELEQVISERDILGSQLVRRNDELALLYEKIKIQQSILNKGEIQYKQRVEDIRLLKLEIKKLRREK 664

  Fly   691 ECLKHAIKSTADMRKEIVRLQRALNQEHIRIRALTEDARTPTGVHRWRILKGEDPKKFELLEKLQ 755
            ..|...:.:..::|:|:..:||.|.:|..|.|||.|:...|..|||||.|:..||..:||::|:.
Frog   665 GILTKTVANVEELRREVYHMQRDLLKERTRCRALEEELENPMNVHRWRKLEASDPSTYELIQKIH 729

  Fly   756 LLQKRSLKQSIENSNLKNKLCEAQKTNETLKRMLSHMPTVEIKHKLVVQQRINRQMAKKLKTLAA 820
            .||||.::::.|....:..|.|.:|....||.:|:..|..|...:|.|.|:..|...|:||.|:|
Frog   730 TLQKRLIRKTEEVVEKELLLQEKEKLYVELKHILARQPGPEAAEQLQVYQKTLRDKTKQLKALSA 794

  Fly   821 ERSLDMVELKSRQ 833
            |  |:|.|.::::
Frog   795 E--LNMYESQNQE 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ORY	NP_001015498.5	Smc	<182..488	CDD:224117	69/315 (22%)
ORY	NP_001015498.5	SMC_prok_B	<363..686	CDD:274008	99/342 (29%)
cfap58	NP_001119542.1	PTZ00121	<2..638	CDD:173412	163/687 (24%)
cfap58	NP_001119542.1	SMC_prok_B	502..>819	CDD:274008	113/323 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1077673at2759
OrthoFinder	1	1.000	-	-		FOG0006172
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4455
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010