DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ORY and ccdc146

DIOPT Version :9

Sequence 1:	NP_001015498.5	Gene:	ORY / 3355174	FlyBaseID:	FBgn0046323	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	XP_005164957.1	Gene:	ccdc146 / 767671	ZFINID:	ZDB-GENE-041210-217	Length:	953	Species:	Danio rerio

Alignment Length:	979	Identity:	209/979 - (21%)
Similarity:	408/979 - (41%)	Gaps:	214/979 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASNKDRKKAKKANNVDENSEPQLLFQEVIDETD-------VLDLNLYSDINDEFFNEANRVVQF 58
            |...:.|..:...::..|:||.......:..|.|       ||.||......::.|:.....|:
Zfish     2 MRQAQQRSSSPSHDDQQESSERATPISALAPEVDLNQEQPAVLSLNPALQCLEQLFSTGKISVE- 65

  Fly    59 LMEAKRHFEASRIKRYSDIIFNLHRRYVDEVNDNEVLRPQILSSEKKLRLALELTSTSEEAMQKL 123
                    :.:|:|    ..|||....:....|:|:   |:|...|.||:.|      |:..|:|
Zfish    66 --------KVARLK----ASFNLLNETLRSSQDSEM---QLLLEAKTLRMTL------EQQRQEL 109

  Fly   124 KDL-LGDAWKESDASALREQLVQ--EKLQEVLIKCEGLADRNSGTTDDTAEFG-----HLAKYKN 180
            ::. |.....:::.|.|::.|:|  .:|:|                |:..::.     ...|.:.
Zfish   110 ENAELFPEGPDTEVSRLKQTLLQYYNQLKE----------------DEERDYQMQFQLECLKEEK 158

  Fly   181 IILRERDRLAGEVVDLEKRLATNRYYSENLEYIIRNNEDAMSKMASRAKFAEGERLNVESKLRAL 245
            :.|.:..:...:..:||.|.||           ::|:.:.:.|          |.|.:..::|.|
Zfish   159 LYLEKEYQDQPKQAELESRYAT-----------LKNSCEEVRK----------EVLKLRQEVRTL 202

  Fly   246 MKTMEEQKEAHGKTMMKL-DIANR----------------ELSETTRKLSQKISDYDRQRVHLDK 293
            .::||.|::...|..::| |:.||                :|.:...:::.|.|:.::|...:::
Zfish   203 TESMETQQKHIKKEQLELEDLKNRVESNEAELAQVLLIPVQLRKEVDRVAHKKSELEKQVAKIEQ 267

  Fly   294 YR----SEVNALNKAMHKNEDDISDLTKNQKNNEEMI-----KQLRLI-----EKEKSNAVSQLT 344
            :|    ....:|.....|.::.|.::.:.|:.::..:     ||.||:     .|.|..|.....
Zfish   268 HRLDNVEHQKSLEAKCEKVKEAIKEVVREQEGHKAQLVTAENKQDRLLTDLQMAKAKEAAFMDQR 332

  Fly   345 SRLKKSIED-QNNATTRMYKLNRKVMMLNSEILRLKNNINSLE--KDVL-NANGRTDDIRRIKET 405
            ..|:.|:|. .....:...||.|...:.:..:|.||.|...|:  :|.| |...:.:.|:..|||
Zfish   333 GLLEISMEQIVAEFISLRDKLARDTRLKDKLMLALKRNELQLKQARDALTNTQQQHERIQAQKET 397

  Fly   406 LQRERDSL---RSDIIK-LNNTMADLKHDMMLKANMISSLNLDMNKLNVKLDEAYILKSKA-EKE 465
            :. |.|.|   |.|:.| :.|          ||.|:||..:  |..:.|:|.:.|:.|.:| .:|
Zfish   398 VS-EADILLERRKDLEKEVEN----------LKRNLISEQS--MAGMKVQLVQEYVEKEQALIRE 449

  Fly   466 RDEMAQEMETLHERIENYQDQISLKTSQVNDLTEKLHEKQREVHSYKKQLESVHSEKMMLQRNLE 530
            ......|:..||.       .|.:||.:....:.:|.:.|.:   ||:..:.:..:.:::|.:::
Zfish   450 SYRRRDELHHLHH-------LILIKTDEKEQKSRELLKAQLK---YKQSKQELQGKGLVIQEHIK 504

  Fly   531 NT--TQER--------------------------DNFRILQAKSGHQIQQL----TTEISANEVK 563
            .|  ||.|                          .|..::|.|.....:.|    :|.||.:::.
Zfish   505 QTKETQTRLGVFAKLYEVTKSKRNKYLSLIQISDQNLALVQEKLAKLEENLKTLQSTAISKDKLL 569

  Fly   564 INSLNLKIEHLNNYIKELQSDLKNK--ENLVA--ALRKDMREMKAKNEMLAKTISNDELKFMKMG 624
            ..|   :::|.::|  :|:.|||.:  :.|.|  .::::..|.|.|...|..|::..|.|.:.:.
Zfish   570 QRS---RLQHSHSY--KLRDDLKKEVSQTLQALQEMQQNREEQKLKLRKLTDTVNMLEQKKLHIC 629

  Fly   625 HELEEMRKERNLVGLQMVRRNDEIVVIKEKLQIAQNALDNGTTQYNQRVEDIRLLKKEISNLHTE 689
            ...|...::||...:|:..|..|..:..|||.:.....:|...:.....::||.||.|......:
Zfish   630 KRYEAELQKRNQESVQLAEREKEWRIFNEKLGVLVKMTENSNLEMYDMEDEIRNLKMEQKEEERQ 694

  Fly   690 SECLKHAIKSTADMRKEIVRLQRALNQEHIRIRALTEDARTPTGVHRWRILKGEDPKKFELLEKL 754
            ::..|..:.:...:.:|.|.||..|::.:.|:..|.|..   ...:|.|.|.||||...||:||:
Zfish   695 NDLHKKQLSNKLALEEERVLLQIQLSEINDRVSELEEAC---VDDNRARNLNGEDPSPEELIEKI 756

  Fly   755 QLLQKRSLKQSIENSNLKNKLCEAQKTNETLKRMLSHMPTVEIKHKLVVQQRINRQMAKKLKTLA 819
            :.|:       |..::.:.:|.|.:...|.:.|:...   ::||.....:..::  :|||:..|.
Zfish   757 EQLE-------IHLADKEAQLLEMELVCEQVGRLSKR---IQIKADNSNEDTLH--LAKKVNELQ 809

  Fly   820 AERSLDMVELKSRQCIINSFAGKISEIGELSILSDGKNEIKSAILDVKNEISKSNMSL-VPQEYM 883
            |:     :..:||:        .::.:.|||:.       |:..:.::.|:.:..:.| :.|:::
Zfish   810 AQ-----IRKRSRK--------MMAVVAELSMR-------KAECMGLQQEMKEKELQLDLCQKHV 854

  Fly   884 ECGL 887
            |.||
Zfish   855 EQGL 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ORY	NP_001015498.5	Smc	<182..488	CDD:224117	76/345 (22%)
ORY	NP_001015498.5	SMC_prok_B	<363..686	CDD:274008	87/366 (24%)
ccdc146	XP_005164957.1	Smc	<65..765	CDD:224117	173/796 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574883
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840