Protein Alignment ORY and CCDC146

DIOPT Version :9

• Sequence 1: NP_001015498.5
• Gene: ORY / 3355174
• FlyBaseID: FBgn0046323
• Length: 914
• Species: Drosophila melanogaster
• Sequence 2: NP_065930.2
• Gene: CCDC146 / 57639
• HGNCID: 29296
• Length: 955
• Species: Homo sapiens
• Alignment Length: 997
• Identity: 200/997 - (20%)
• Similarity: 429/997 - (43%)
• Gaps: 196/997 - (19%)

  Fly     3 SNKDRKKAKKANNVDENSEPQLLFQEVIDETDVLDLNLYSDINDEFFNEANRVVQFL----MEAK 63
            |:.|.:|.::....:::.||.......|            :|.||.|.:.:....|:    :.|.
Human     4 SSTDTEKEEEEEKDEKDQEPIYAIVPTI------------NIQDERFVDLSETPAFIFLHELHAM 56

  Fly    64 RHFEASRIKRYSDIIFNLHRRYVDEVNDNEVLRPQILSSEKKLRLALELTSTSEEAMQKLKDLLG 128
            .....:|:.........||    |.|...:....|:|.:.|:.        |.:...|:......
Human    57 GKLPGTRMAALKAKYTLLH----DAVMSTQESEVQLLQNAKRF--------TEQIQQQQFHLQQA 109

  Fly   129 DAWKE---SDASALREQLVQEKLQEVLIKCEGLADRNSGTTDDTAEF------GHLAKYKNIILR 184
            |.:.|   ::.|.:||||::.:.:...:|              ..||      ..|.:.|.||::
Human   110 DNFPEAFSTEVSKMREQLLKYQNEYNAVK--------------EREFHNQYRLNSLKEEKIIIVK 160

  Fly   185 ERDRLA--GEVVDLEKRLATNRYYSENLEYIIRNNEDAMSKMASRAKF-AEGERLNVESKLRALM 246
            |.:::.  ||   :||::.           |:|.:.:.:.|...:.|. .:..|.::.||.:.|:
Human   161 EFEKITKPGE---MEKKMK-----------ILRESTEELRKEIMQKKLEIKNLREDLASKQKQLL 211

  Fly   247 KTMEEQKEAHG-KTMMKLDIANR-----ELSETTRKLSQKISDYDRQRVHLDKYRSEVNALNKAM 305
            |..:|.:|..| :.::|.::|:.     ::.:...|:::|..:.:::::.|::   ||..||.::
Human   212 KEQKELEELLGHQVVLKDEVAHHQTIPVQIGKEIEKITRKKVEMEKKKIVLEQ---EVKTLNDSL 273

  Fly   306 HKNEDDISDLTKNQKNNEEMIKQ------------------LRLIEKEKSNAVSQLTSR------ 346
            .|.|:.:|.:...::|   :||:                  ::|:|..:.|..:.||.|
Human   274 KKVENKVSAIVDEKEN---VIKEVEGKRALLEIKEREHNQLVKLLELARENEATSLTERGILDLN 335

  Fly   347 LKKSIEDQNNATTRMYKLNRKVMMLNSEILRLKNNINSLEKDVLNANGRTDDIRRIKETLQR--- 408
            |:.|:.|:.|....:.:..|:          .:.:..:|.|..|......|.:|:.:...||
Human   336 LRNSLIDKQNYHDELSRKQRE----------KERDFRNLRKMELLLKVSWDALRQTQALHQRLLL 390

  Fly   409 ERDSLRSDIIKLNNTMADLKHDMMLKANMISSLNLDMNKLNVKLDEAYILKSKAEKERDEMAQEM 473
            |.:::..|    ::|:::.:.::. |...::..||...|:..:::...:.:..||:  :::.:|.
Human   391 EMEAIPKD----DSTLSERRRELH-KEVEVAKRNLAQQKIISEMESKLVEQQLAEE--NKLLKEQ 448

  Fly   474 ETLHERIENY----------QDQIS---LKTSQ-VNDLTEKLHEKQREVHSYKKQLESVHSEKMM 524
            |.:.|.:.|.          ::|.|   ||..| ..::.:::..|..|:..:||:...::.....
Human   449 ENMKELVVNLLRMTQIKIDEKEQKSKDFLKAQQKYTNIVKEMKAKDLEIRIHKKKKCEIYRRLRE 513

  Fly   525 LQRNLENTTQERDNFRILQAKSGHQIQQLTT--EISANEVKI--NSL--------NLKIEHLNNY 577
            ..:..:....||:.|..|..|:..::.::..  ::|.||::|  ||.        |..::|.||.
Human   514 FAKLYDTIRNERNKFVNLLHKAHQKVNEIKERHKMSLNELEILRNSAVSQERKLQNSMLKHANNV 578

  Fly   578 -IKE-LQSDLKNKENLVAALR--KDMREMKAKN-EMLAKTISNDELKFMKMGHELEEMRKERNLV 637
             |:| :|:|::   .:|:.|:  |:.:|.:..| :.||.||:..|.:.:::....|:..:.||..
Human   579 TIRESMQNDVR---KIVSKLQEMKEKKEAQLNNIDRLANTITMIEEEMVQLRKRYEKAVQHRNES 640

  Fly   638 GLQMVRRNDEIVVIKEKLQIAQNALDNGTTQYNQRVEDIRLLKKEISNLHTESECLKHAIKSTAD 702
            |:|::.|.:||.:..||:.|.:....||..:.:...|.|:.||.:|:....:....:..:.:...
Human   641 GVQLIEREEEICIFYEKINIQEKMKLNGEIEIHLLEEKIQFLKMKIAEKQRQICVTQKLLPAKRS 705

  Fly   703 MRKEIVRLQRALNQEHIRIRALTEDARTPTGVHRWRILKGEDPKKFELLEKLQLLQKRSLKQSIE 767
            :..::..||...:|...||:.|.:....|.|.:|.|.|.|:|..:.|:::||..|:.:..|:
Human   706 LDADLAVLQIQFSQCTDRIKDLEKQFVKPDGENRARFLPGKDLTEKEMIQKLDKLELQLAKK--- 767

  Fly   768 NSNLKNKLCEAQKTNETLKRMLSHM---------PTVEIKHKLVVQQRINRQMAKKLKTLAAERS 823
                :.||.|.....|.:.|:...:         .|:.:..|:...||..:...:|:..|.||.|
Human   768 ----EEKLLEKDFIYEQVSRLTDRLCSKTQGCKQDTLLLAKKMNGYQRRIKNATEKMMALVAELS 828

  Fly   824 LDMV-------ELKSRQCIINSFAGKISEIGELSILSDGKNEIKSAILDVKNEISKSNMSLV--P 879
            :...       |::.::..|.:...:|.:...|:      .||:...|.|..:.....:::.  .
Human   829 MKQALTIELQKEVREKEDFIFTCNSRIEKGLPLN------KEIEKEWLKVLRDEEMHALAIAEKS 887

  Fly   880 QEYMEC-------GLFSDADTK 894
            ||::|.       |:::.|:.:
Human   888 QEFLEADNRQLPNGVYTTAEQR 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORY	NP_001015498.5	Smc	<182..488	CDD:224117	65/351 (19%)
		SMC_prok_B	<363..686	CDD:274008	77/356 (22%)
CCDC146	NP_065930.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		3/17 (18%)
		Smc	68..859	CDD:224117	177/863 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840