DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ORY and cfap58

DIOPT Version :9

Sequence 1:	NP_001015498.5	Gene:	ORY / 3355174	FlyBaseID:	FBgn0046323	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001071024.3	Gene:	cfap58 / 561732	ZFINID:	ZDB-GENE-060929-128	Length:	885	Species:	Danio rerio

Alignment Length:	869	Identity:	225/869 - (25%)
Similarity:	409/869 - (47%)	Gaps:	72/869 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NKDRKKAKKANNVDENSEP-QLLFQEVIDETDVLDLNLYSDINDEFFNEANRVVQFLMEAKRHFE 67
            ||:.::.......|...|. ::.||||::|..          .||.|:      :|.:|.::..:
Zfish     2 NKEERQTTTMETDDSTLETMEIGFQEVLNELS----------GDEKFD------KFRVEYEKVTK 50

  Fly    68 ASRIKRYSDIIFNLHRRYVDEVNDNEVLRPQILSSEKKLRLALELTSTSEEAMQKLKDLLGDAWK 132
            |.|....::      :|.:.:..:   |..:|:|:..||..|::|....:.::..||..:..|||
Zfish    51 ALRKSHENE------KRLMAKCRE---LNAEIVSNSVKLSTAMKLVDEDQASINTLKQEIDKAWK 106

  Fly   133 ESDASALREQLVQE---KLQEVLIKCEGLADRNSGTT-DDTAEFGHLAKYKNIILRERDRLAGEV 193
            ..:||..:|...:|   |.:|.:.....|.::.:|.: ......|.|.|.|..:..:||:|..||
Zfish   107 MVEASHEKELQAKETIKKHKEEIANLNNLVEKGAGVSGGQEYSVGDLLKIKEELTEQRDKLLSEV 171

  Fly   194 VDLEKRLATNRYYSENLEYIIRNNEDAMSKMASRAKFAEGE---RLNVESKLRALMKTMEEQKEA 255
            |.|.:.|.......:.:|.......|.::::....:..:.|   ....:.||...:|..:...|:
Zfish   172 VTLRENLTKATGAQQEIEAEKNKAMDMIAQLQQEIQVRQNEVHRETRRKEKLEKEVKQFQTDLES 236

  Fly   256 HGKTMMKLDIANRELSETTRKLSQKISDYDRQRVHLDKYRSEVNAL----NKAMHKNEDDISDLT 316
            ....:..|...::.|.:..:||.|.:.::   ::..:|...|:..|    .|....||.:..:|.
Zfish   237 KQSEIKLLTQQSQRLQDDQQKLEQLLQEH---KIINEKSSKEMEQLQHRNTKLQQDNEQNSINLE 298

  Fly   317 KNQKNNEEMIKQLRLIEKEKSNAVSQLTSRLKKSIEDQNNATTRMYKLNRKVMMLNSEILRLKNN 381
            :..:.|::....|::.|:|    |:||...:.|....:..|..|:.::..:...:.::...|||.
Zfish   299 QLSQQNQQRASDLKMKEEE----VTQLKQEITKLTRLREGAQRRLRQMEEQKAEVENQRETLKNQ 359

  Fly   382 INSLEKDVLNANGRTDDIRRIKETLQRERDSLRSDIIKLNNTMADLKHDMMLKANMISSLNLDMN 446
            |..||:::..:..:.|..::..:.|.||||.|..::||..|...  |...::|.:..|...|:..
Zfish   360 ITGLEREMEASKNQIDADKKAIDELVRERDILNKNMIKAANETD--KQQTLVKLHEQSKKTLEHE 422

  Fly   447 KLNVKLDEAYILKS---KAEKERDEMAQEMETLHERI-ENYQDQISLKTSQVNDLTEKLHEKQRE 507
            .||.: |||...:.   :.|||||....|...|.::: ||.:| |.||..|:.:..:::.|.:.:
Zfish   423 ILNYR-DEAQKQRKIIYQLEKERDRYINEASELTKKVLENIED-IKLKEMQIFEYKKRIAEAETK 485

  Fly   508 VHSYKKQLESVHSEKMMLQRNLENTTQERDNFRILQAKSGHQIQQLTTEISANEVKINSLNLKIE 572
            :...:...|.|.:|:.:..:||.....:....|.......|..:||..||:|.||.
Zfish   486 LKQQQNLYEDVRTERNLFSKNLIEAKDQNAEMRRKVKIVNHMFEQLKDEITAKEVA--------- 541

  Fly   573 HLNNYIKELQSDLKNKENLVAALRK------DMREMKAKNEM----LAKTISNDELKFMKMGHEL 627
             |:...:|.|...:.:|||.|.|:|      :.:::.||.:.    |.|.|:..:.:.::...||
Zfish   542 -LDKERQEFQRVERERENLKAELQKMKLQAQETKQLLAKQQAQEQELLKIIAEADAERIRQKKEL 605

  Fly   628 EEMRKERNLVGLQMVRRNDEIVVIKEKLQIAQNALDNGTTQYNQRVEDIRLLKKEISNLHTESEC 692
            :::..||:|:|.|:|:|||.:.::.||::|.|:.|:.|...||:|:||||:||.||.....|...
Zfish   606 DQVISERDLLGTQLVKRNDSLALLYEKVKIQQSILNKGEVHYNERLEDIRVLKIEIKKQRREKSI 670

  Fly   693 LKHAIKSTADMRKEIVRLQRALNQEHIRIRALTEDARTPTGVHRWRILKGEDPKKFELLEKLQLL 757
            |...:.:..|:|:|:..:.|.|.:|..|.|||.::...|..|||||.|:..||..|||::|:..|
Zfish   671 LSKTVINVDDLRQEVFHMHRELMKERTRCRALEDELNNPLNVHRWRKLEASDPSSFELIQKIHSL 735

  Fly   758 QKRSLKQSIENSNLKNKLCEAQKTNETLKRMLSHMPTVEIKHKLVVQQRINRQMAKKLKTLAAER 822
            |:|.:.::.|....:..|.|.:|....||.:|:..|..|...||.|.||..|:..|:||.|.||.
Zfish   736 QRRLISKTQEVVEKELLLQEKEKLYVELKHILARQPGPEAAEKLQVYQRTLREKTKQLKALTAEL 800

  Fly   823 SLDMVELKSRQCIINSFAGKISEI 846
            ::...:.:..:..|.....::.|:
Zfish   801 NMHESQAEGYKYEIERLVHELQEV 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ORY	NP_001015498.5	Smc	<182..488	CDD:224117	72/316 (23%)
ORY	NP_001015498.5	SMC_prok_B	<363..686	CDD:274008	96/336 (29%)
cfap58	NP_001071024.3	Smc	218..>845	CDD:224117	173/628 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574884
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1077673at2759
OrthoFinder	1	1.000	-	-		FOG0006172
OrthoInspector	1	1.000	-	-		otm26577
orthoMCL	1	0.900	-	-		OOG6_103263
Panther	1	1.100	-	-	O	PTHR32083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5074
SonicParanoid	1	1.000	-	-		X4455
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.880