DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ORY and LAMA3

DIOPT Version :9

Sequence 1:	NP_001015498.5	Gene:	ORY / 3355174	FlyBaseID:	FBgn0046323	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	XP_011524280.1	Gene:	LAMA3 / 3909	HGNCID:	6483	Length:	3342	Species:	Homo sapiens

Alignment Length:	1101	Identity:	220/1101 - (19%)
Similarity:	408/1101 - (37%)	Gaps:	327/1101 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NKDRKKAK----KANNVDENSEPQLLFQEVIDETDVLDLNLYSDINDEFFNEANRVVQFLMEAKR 64
            |:..:.||    |..||..|  ..:|.:: |..||....|:.|......:.||.|:::.|  ..|
Human  1933 NRATQSAKELDVKIKNVIRN--VHILLKQ-ISGTDGEGNNVPSGDFSREWAEAQRMMREL--RNR 1992

  Fly    65 HF-----EASRIKRYSDIIFNLHRRYV---------------DEVNDNEV----LRPQILSSEKK 105
            :|     ||...||.|.::.|..|.:.               |.:|:.|.    ||.::..:..:
Human  1993 NFGKHLREAEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQ 2057

  Fly   106 LRLALELTSTSEEAM-------QKLKDLLGDAWK---ESDASALRE----QLVQEKLQEVLIKCE 156
            .:.|..|...:|.|:       :::..|..|..|   .:|:|.|:.    ||:::..:|......
Human  2058 AKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAA 2122

  Fly   157 GLADRNSGTTDDTAEFGHLAKYKNIILRERDRLAGEVVDLEKRL------------------ATN 203
            .|.:.....:|...|....|. |..::.|.::.|..:.:|.|:|                  |..
Human  2123 SLNEARQELSDKVRELSRSAG-KTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAAT 2186

  Fly   204 RYYSENLEYIIRNNEDAMSKMASRAKFAEGERLNVESKLRALMKTMEEQKEAHGKTM-MKLDIAN 267
            .|  ||:...|:..|||.::.||.:          ||.|:.::|   |......||: ...|...
Human  2187 AY--ENILNAIKAAEDAANRAASAS----------ESALQTVIK---EDLPRKAKTLSSNSDKLL 2236

  Fly   268 RELSETTRKLSQKIS---DYDRQRVHLDKYRSEVNALN-----------------------KAMH 306
            .|...|.:||.|::|   :..:|.:::...:.||...|                       |:|.
Human  2237 NEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMV 2301

  Fly   307 KNEDDISDLTKNQKNNEEMIKQLRLI----EKEKSNAVSQLTSRLKKSIEDQNNA----TTRMYK 363
            :..:||:|         |::..|..|    |:.|...........||::.|.:|:    |.::..
Human  2302 RKANDITD---------EVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPD 2357

  Fly   364 LNRKVMMLNSEILRLKNNINSLEKDVLNANGRTDDIRRIKETLQRERDSL-----------RSDI 417
            |.||:..:|.::|.|.|              .:|::.||:|.:|:.||:.           :|.:
Human  2358 LWRKIESINQQLLPLGN--------------ISDNMDRIRELIQQARDAASKVAVPMRFNGKSGV 2408

  Fly   418 -IKLNNTMADLKHDMMLKANMISSLNLDMNKLNVK-------LDEAYILKSKAEKERDEMAQE-- 472
             ::|.|.:.|||.        .:||:|.:.:.|.:       :...|:....|.::...||..
Human  2409 EVRLPNDLEDLKG--------YTSLSLFLQRPNSRENGGTENMFVMYLGNKDASRDYIGMAVVDG 2465

  Fly   473 ----METLHERIENYQ-DQISLKTSQVNDLTEKLHEKQREVHSY------------KKQLESVHS 520
                :..|.:|....| |||..|:.....:.:::  |.:.::.:            |.:...|:.
Human  2466 QLTCVYNLGDREAELQVDQILTKSETKEAVMDRV--KFQRIYQFARLNYTKGATSSKPETPGVYD 2528

  Fly   521 EKMMLQRNLENTTQERDNFRILQAKSGHQIQ-QLTTEIS----ANEVKINSLNLKIEHLNNYIKE 580
               |..|| .||....|...::....|:... :|.:.:|    ...::::.||..:..|.|:.|.
Human  2529 ---MDGRN-SNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKT 2589

  Fly   581 LQSDLKNKENLVAALRKDMREMKAKN----------------------EMLAKTISNDELKFMKM 623
            .  :|...|  |...|: .:|...||                      :.:..|:....|.|.:.
Human  2590 F--NLNTTE--VEPCRR-RKEESDKNYFEGTGYARVPTQPHAPIPTFGQTIQTTVDRGLLFFAEN 2649

  Fly   624 GHEL-----------------EEMRKERNLVGLQMVRRNDEIVVIK-EKLQ-------IAQNALD 663
            |...                 .|:.|||. ||..:....|..:.|| .|||       ..||.:.
Human  2650 GDRFISLNIEDGKLMVRYKLNSELPKERG-VGDAINNGRDHSIQIKIGKLQKRMWINVDVQNTII 2713

  Fly   664 NG-----TTQYNQRVEDIRLLKKEISNLHTES--ECLKHAIKSTADMRKEIVRLQRALNQEHIRI 721
            :|     :|.|   :..|.:..:|..|:.|.:  .|:|:..|::.     :|||...:..    .
Human  2714 DGEVFDFSTYY---LGGIPIAIRERFNISTPAFRGCMKNLKKTSG-----VVRLNDTVGV----T 2766

  Fly   722 RALTEDARTPTGVHRWRILK---------------GEDPKK-------FELLEKLQLL-----QK 759
            :..:||         |::::               |..|..       |:..:...:|     ..
Human  2767 KKCSED---------WKLVRSASFSRGGQLSFTDLGLPPTDHLQASFGFQTFQPSGILLDHQTWT 2822

  Fly   760 RSLKQSIENSNLKNKLCEAQ----KTNETLKRMLSHMPTVEIKH---KLVVQQRINRQMAKKLKT 817
            |:|:.::|:..::....::.    |:.:|....|.|..:|...:   :|::..::.|. :|:||.
Human  2823 RNLQVTLEDGYIELSTSDSGGPIFKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRN-SKRLKH 2886

  Fly   818 LAAER-SLDMVELKSRQCIINSFAGKISEIGELSILSDGKNEIKSAILDVKNEISKSNMSL 877
            :::.| ||.:.......||.|.|..::|              :...:||:.:...|.::||
Human  2887 ISSSRQSLRLGGSNFEGCISNVFVQRLS--------------LSPEVLDLTSNSLKRDVSL 2933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ORY	NP_001015498.5	Smc	<182..488	CDD:224117	81/384 (21%)
ORY	NP_001015498.5	SMC_prok_B	<363..686	CDD:274008	82/417 (20%)
LAMA3	XP_011524280.1	LamNT	46..297	CDD:214532
		EGF_Lam	299..344	CDD:238012
		Laminin_EGF	356..423	CDD:278482
		EGF_Lam	425..465	CDD:238012
		Laminin_EGF	491..538	CDD:278482
		EGF_Lam	535..577	CDD:238012
		Laminin_EGF	585..628	CDD:278482
		EGF_Lam	631..682	CDD:238012
		EGF_Lam	684..727	CDD:238012
		Laminin_EGF	1275..1323	CDD:278482
		EGF_Lam	1365..1410	CDD:238012
		EGF_Lam	1413..1463	CDD:238012
		LamB	1523..1650	CDD:214597
		EGF_Lam	1695..1741	CDD:238012
		Laminin_EGF	1743..1793	CDD:278482
		Laminin_I	1854..2113	CDD:283627	43/184 (23%)
		Laminin_I	2071..2357	CDD:283627	63/310 (20%)
		ApoLp-III_like	2101..2265	CDD:304399	39/179 (22%)
		Laminin_II	2297..2425	CDD:283628	35/158 (22%)
		LamG	2444..2579	CDD:214598	25/140 (18%)
		LamG	2611..2751	CDD:238058	27/143 (19%)
		LamG	2778..2910	CDD:238058	23/132 (17%)
		LamG	3003..3143	CDD:238058
		LamG	3167..3318	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910