Protein Alignment ORY and Lama1

DIOPT Version :10

• Sequence 1: NP_001015498.5
• Gene: ORY / 3355174
• FlyBaseID: FBgn0046323
• Length: 914
• Species: Drosophila melanogaster
• Sequence 2: NP_032506.2
• Gene: Lama1 / 16772
• MGIID: 99892
• Length: 3083
• Species: Mus musculus
• Alignment Length: 618
• Identity: 121/618 - (19%)
• Similarity: 238/618 - (38%)
• Gaps: 128/618 - (20%)

  Fly   182 ILRERDRLAGEVVDLEKRLATNRYYS--ENLE--------YIIRNNEDAMSKMASRAKFAEGERL 236
            :|.:.|.:...|:.|.....:...|.  ||||        |:|:.|               .:::
Mouse  1571 LLNDLDSVGDAVLSLNLTGVSPAPYGILENLENTTKYFQRYLIKEN---------------AKKI 1620

  Fly   237 NVESKLRALMKTMEEQKEAHGKTMMKLDIANRELSETT-----------------RKLSQKISDY 284
            ..|.:|..:.:..|..::...:.:.:....|.|:..|:                 :::::|::..
Mouse  1621 RAEIQLEGIAEQTENLQKELTRVLARHQKVNAEMERTSNGTQALATFIEQLHANIKEITEKVATL 1685

  Fly   285 DRQRVHLDKYRSEVNALNKAMHKNEDDISDLTKNQKNNEEMIKQLRL-----------IEK---- 334
            : |....| ::..|:|| ::||:|...:..|.| ::|..||.:...|           |:|
Mouse  1686 N-QTARKD-FQPPVSAL-QSMHQNISSLLGLIK-ERNFTEMQQNATLELKAAKDLLSRIQKRFQK 1746

  Fly   335 --EKSNAVSQLTSRLKKSIEDQNNATTRMYKLNRKVMMLNSEILRLKNNINSLEKDVLNANGRTD 397
              ||..|:.:..|.|....|....|...:.:...|....|..:|.:|.|:...::..|    |..
Mouse  1747 PQEKLKALKEANSLLSNHSEKLQAAEELLKEAGSKTQESNLLLLLVKANLKEFQEKKL----RVQ 1807

  Fly   398 DIRRI-KETLQRER---DSLRSDIIKLNNTMADLKH---DMMLKANMISSLNLDMNKLNVKLDEA 455
            :.:.: .|.:.:.|   |:..:......:|:..|:|   :::|.|..|.| ::|...:.:....|
Mouse  1808 EEQNVTSELIAKGREWVDAAGTHTAAAQDTLTQLEHHRDELLLWARKIRS-HVDDLVMQMSKRRA 1871

  Fly   456 YILKSKAEKERDEMAQEMETLHERIENYQDQISLKTSQVNDLTEKLHEKQREVHSYKKQLESVHS 520
            ..|..:||:...|:......|...:||.:: :||      :.|...|     |||   .::::..
Mouse  1872 RDLVHRAEQHASELQSRAGALDRDLENVRN-VSL------NATSAAH-----VHS---NIQTLTE 1921

  Fly   521 EKMMLQRNLENTTQERDNFRILQAKSGHQIQQLTTEISANEV----KINSLNLKIEHLNNYIKEL 581
            |..||..:...|..:.|......|..|..:.|.::......|    |...:.:|::.|.|...:.
Mouse  1922 EAEMLAADAHKTANKTDLISESLASRGKAVLQRSSRFLKESVSTRRKQQGITMKLDELKNLTSQF 1986

  Fly   582 QSD----LKNKENLVAALRKD---MREMKAKNEMLAKTISNDELKFMKMGHELEEMRKERNLVGL 639
            |..    :|...:.:|.||:.   |||...|...||...:...:|      .||::.    .:.|
Mouse  1987 QESMDNIMKQANDSLAMLRESPGGMREKGRKARELAAAANESAVK------TLEDVL----ALSL 2041

  Fly   640 QMVRRNDEIVVIKEKLQIAQNALDNGT--------------TQYNQRVEDIRLLKKEISNLHTES 690
            ::...::::..:...:|...:.|.|.|              .|.|..::.::.||....||....
Mouse  2042 RVFNTSEDLSRVNATVQETNDLLHNSTMTTLLAGRKMKDMEMQANLLLDRLKPLKTLEENLSRNL 2106

  Fly   691 ECLKHAIKSTADMRKEIVRLQRALNQEHIRIRA 723
            ..:|..|...   ||::..::.|::.:...|||
Mouse  2107 SEIKLLISRA---RKQVASIKVAVSADRDCIRA 2136

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORY	NP_001015498.5	SMC_N	<111..435	CDD:481474	56/303 (18%)
		DR0291	290..>417	CDD:441187	32/147 (22%)
		SMC_prok_B	<363..686	CDD:274008	69/354 (19%)
Lama1	NP_032506.2	LamNT	25..275	CDD:214532
		EGF_Lam	277..324	CDD:238012
		Laminin_EGF	404..463	CDD:395007
		Laminin_EGF	461..507	CDD:395007
		Laminin_B	575..714	CDD:459652
		EGF_Lam	<715..739	CDD:214543
		EGF_Lam	748..796	CDD:238012
		Laminin_EGF	798..853	CDD:395007
		EGF_Lam	855..907	CDD:238012
		Laminin_EGF	909..955	CDD:395007
		EGF_Lam	958..1002	CDD:214543
		EGF_Lam	1004..1049	CDD:238012
		Laminin_EGF	1051..1099	CDD:395007
		Laminin_EGF	1097..1154	CDD:395007
		Cell attachment site	1147..1149
		Laminin_B	1225..1367	CDD:459652
		Laminin_EGF	1410..1456	CDD:395007
		Laminin_EGF	1459..1513	CDD:395007
		EGF_Lam	1516..>1553	CDD:238012
		Domain II and I	1564..2123		117/603 (19%)
		Laminin_I	1582..1837	CDD:310534	50/277 (18%)
		COG4372	1711..2035	CDD:443500	74/350 (21%)
		Laminin_II	2018..2152	CDD:368703	24/132 (18%)
		LamG	2136..2285	CDD:238058	1/1 (100%)
		LamG	2314..2470	CDD:238058
		LamG	2495..2659	CDD:238058
		Laminin_G_1	2751..2880	CDD:395008
		LamG	2900..3053	CDD:238058