DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ORY and CFAP58

DIOPT Version :9

Sequence 1:	NP_001015498.5	Gene:	ORY / 3355174	FlyBaseID:	FBgn0046323	Length:	914	Species:	Drosophila melanogaster
Sequence 2:	NP_001008723.1	Gene:	CFAP58 / 159686	HGNCID:	26676	Length:	872	Species:	Homo sapiens

Alignment Length:	836	Identity:	218/836 - (26%)
Similarity:	406/836 - (48%)	Gaps:	85/836 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 INDEFFNEANRVVQFL---MEAKRHFEASRIKRYSDIIFNLHRRYVDEVNDNE--------VLRP 97
            :.:..|.|..|..|.:   :...:..|..||: |..:...:.:.|     |||        .|..
Human    11 LEESAFEEMERDFQGVLHELSGDKSLEKFRIE-YERLHAVMKKSY-----DNEKRLMAKCRELNA 69

  Fly    98 QILSSEKKLRLALELTSTSEEAMQKLKDLLGDAWKESDASALREQLVQE---KLQEVLIKCEGLA 159
            :|:.:..|:..||:|:...:..:..||..:..|||..|::..:||..:|   .|:|.::....|.
Human    70 EIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLV 134

  Fly   160 DRNSG-TTDDTAEFGHLAKYKNIILRERDRLAGEVVDLEKRLATNRYYSENLEYIIRNNEDAMSK 223
            ::.|| :.|..:....|.::|..:.:|||:|..|||.|.:.||......:..|......|.|:|:
Human   135 EQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQ 199

  Fly   224 M----------ASRAKFAEGERLNVESK------------LRALMKTMEEQKEAHGKTMMKLDIA 266
            .          ||| :|.:.|:|..|.|            ::||.:.:::.||    .:.||:..
Human   200 FQQEIQQRQNEASR-EFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKE----ELQKLEQQ 259

  Fly   267 NRELSETTRKLSQKISDYDRQRVHLDKYRSEVNAL--NKAMHKNEDDISDLTKNQKNNEEMIKQL 329
            .:|......:.::::..:..:...|.: .:|.::|  .:...:|:....:|    |..||.:.|:
Human   260 LKEQKILNERAAKELEQFQMRNAKLQQ-ENEQHSLVCEQLSQENQQKALEL----KAKEEEVHQM 319

  Fly   330 RLIEKEKSNAVSQLTSRLKKSIEDQNNATTRMYKLNRKVMMLNSEILRLKNNINSLEKDVLNANG 394
            || :..|.|.:.:...:.....||| .|....:|..            |||.|..||::|..:..
Human   320 RL-DIGKLNKIREQIHKKLHHTEDQ-KAEVEQHKET------------LKNQIVGLEREVEASKK 370

  Fly   395 RTDDIRRIKETLQRERDSLRSDIIKLNNTMADLKHDMMLKANMISSLNLDMNKLNVKLDEAYILK 459
            :.:..|:..:.|.||||.|..:::|..|  |..|...::|.:..:..||:....|.| |||...:
Human   371 QAELDRKAMDELLRERDILNKNMLKAVN--ATQKQTDLVKLHEQAKRNLEGEIQNYK-DEAQKQR 432

  Fly   460 S---KAEKERDEMAQEMETLHERIENYQDQISLKTSQVNDLTEKLHEKQREVHSYKKQLESVHSE 521
            .   ..|||||....:...|.:::....:.|.::.:|:.|..:|:.|.:.::...:...|:|.|:
Human   433 KIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSD 497

  Fly   522 KMMLQRNL----ENTTQERDNFRILQAKSGHQIQQLTTEISANEVKINSLNLKIEHLNNYIKELQ 582
            :.:..:||    :..|..:...:|:.    ||:.:|..:|||.|..:..|:|:.:.:....:.|:
Human   498 RNLYSKNLVEAQDEITDMKRKLKIMI----HQVDELKEDISAKESALVKLHLEQQRIEKEKETLK 558

  Fly   583 SDLKNKENLVAALRKDMREMKAKNEMLAKTISNDELKFMKMGHELEEMRKERNLVGLQMVRRNDE 647
            ::|:.........:..:.:.:|:...|.:.|:..:.:.::...||:::..||:::|.|:||||||
Human   559 AELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDE 623

  Fly   648 IVVIKEKLQIAQNALDNGTTQYNQRVEDIRLLKKEISNLHTESECLKHAIKSTADMRKEIVRLQR 712
            :.::.||::|.|:.|:.|.:|||||:||:|:|:.||..|..|...|..::.:..::|:|...:||
Human   624 LALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQR 688

  Fly   713 ALNQEHIRIRALTEDARTPTGVHRWRILKGEDPKKFELLEKLQLLQKRSLKQSIENSNLKNKLCE 777
            .|.:|..|.|||.|:...|..|||||.|:..||..:||::|:..||||.:.::.|....:..|.|
Human   689 ELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQE 753

  Fly   778 AQKTNETLKRMLSHMPTVEIKHKLVVQQRINRQMAKKLKTLAAERSLDMVELKSRQ 833
            .:|....||.:|:..|..|...:|.:.:|......::||.|::|  |:|.|::|::
Human   754 KEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSE--LNMYEVQSKE 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ORY	NP_001015498.5	Smc	<182..488	CDD:224117	79/332 (24%)
ORY	NP_001015498.5	SMC_prok_B	<363..686	CDD:274008	88/329 (27%)
CFAP58	NP_001008723.1	Smc	<33..>709	CDD:224117	180/712 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141973
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1077673at2759
OrthoFinder	1	1.000	-	-		FOG0006172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103263
Panther	1	1.100	-	-	O	PTHR32083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5074
SonicParanoid	1	1.000	-	-		X4455
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.880