Protein Alignment ORY and CFAP58

DIOPT Version :10

• Sequence 1: NP_001015498.5
• Gene: ORY / 3355174
• FlyBaseID: FBgn0046323
• Length: 914
• Species: Drosophila melanogaster
• Sequence 2: NP_001008723.1
• Gene: CFAP58 / 159686
• HGNCID: 26676
• Length: 872
• Species: Homo sapiens
• Alignment Length: 836
• Identity: 218/836 - (26%)
• Similarity: 406/836 - (48%)
• Gaps: 85/836 - (10%)

  Fly    44 INDEFFNEANRVVQFL---MEAKRHFEASRIKRYSDIIFNLHRRYVDEVNDNE--------VLRP 97
            :.:..|.|..|..|.:   :...:..|..||: |..:...:.:.|     |||        .|..
Human    11 LEESAFEEMERDFQGVLHELSGDKSLEKFRIE-YERLHAVMKKSY-----DNEKRLMAKCRELNA 69

  Fly    98 QILSSEKKLRLALELTSTSEEAMQKLKDLLGDAWKESDASALREQLVQE---KLQEVLIKCEGLA 159
            :|:.:..|:..||:|:...:..:..||..:..|||..|::..:||..:|   .|:|.::....|.
Human    70 EIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIVNLTKLV 134

  Fly   160 DRNSG-TTDDTAEFGHLAKYKNIILRERDRLAGEVVDLEKRLATNRYYSENLEYIIRNNEDAMSK 223
            ::.|| :.|..:....|.::|..:.:|||:|..|||.|.:.||......:..|......|.|:|:
Human   135 EQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQ 199

  Fly   224 M----------ASRAKFAEGERLNVESK------------LRALMKTMEEQKEAHGKTMMKLDIA 266
            .          ||| :|.:.|:|..|.|            ::||.:.:::.||    .:.||:..
Human   200 FQQEIQQRQNEASR-EFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKE----ELQKLEQQ 259

  Fly   267 NRELSETTRKLSQKISDYDRQRVHLDKYRSEVNAL--NKAMHKNEDDISDLTKNQKNNEEMIKQL 329
            .:|......:.::::..:..:...|.: .:|.::|  .:...:|:....:|    |..||.:.|:
Human   260 LKEQKILNERAAKELEQFQMRNAKLQQ-ENEQHSLVCEQLSQENQQKALEL----KAKEEEVHQM 319

  Fly   330 RLIEKEKSNAVSQLTSRLKKSIEDQNNATTRMYKLNRKVMMLNSEILRLKNNINSLEKDVLNANG 394
            || :..|.|.:.:...:.....||| .|....:|..            |||.|..||::|..:..
Human   320 RL-DIGKLNKIREQIHKKLHHTEDQ-KAEVEQHKET------------LKNQIVGLEREVEASKK 370

  Fly   395 RTDDIRRIKETLQRERDSLRSDIIKLNNTMADLKHDMMLKANMISSLNLDMNKLNVKLDEAYILK 459
            :.:..|:..:.|.||||.|..:::|..|  |..|...::|.:..:..||:....|.| |||...:
Human   371 QAELDRKAMDELLRERDILNKNMLKAVN--ATQKQTDLVKLHEQAKRNLEGEIQNYK-DEAQKQR 432

  Fly   460 S---KAEKERDEMAQEMETLHERIENYQDQISLKTSQVNDLTEKLHEKQREVHSYKKQLESVHSE 521
            .   ..|||||....:...|.:::....:.|.::.:|:.|..:|:.|.:.::...:...|:|.|:
Human   433 KIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESEIKLKQQQNLYEAVRSD 497

  Fly   522 KMMLQRNL----ENTTQERDNFRILQAKSGHQIQQLTTEISANEVKINSLNLKIEHLNNYIKELQ 582
            :.:..:||    :..|..:...:|:.    ||:.:|..:|||.|..:..|:|:.:.:....:.|:
Human   498 RNLYSKNLVEAQDEITDMKRKLKIMI----HQVDELKEDISAKESALVKLHLEQQRIEKEKETLK 558

  Fly   583 SDLKNKENLVAALRKDMREMKAKNEMLAKTISNDELKFMKMGHELEEMRKERNLVGLQMVRRNDE 647
            ::|:.........:..:.:.:|:...|.:.|:..:.:.::...||:::..||:::|.|:||||||
Human   559 AELQKLRQQALETKHFIEKQEAEERKLLRIIAEADGERLRQKKELDQVISERDILGSQLVRRNDE 623

  Fly   648 IVVIKEKLQIAQNALDNGTTQYNQRVEDIRLLKKEISNLHTESECLKHAIKSTADMRKEIVRLQR 712
            :.::.||::|.|:.|:.|.:|||||:||:|:|:.||..|..|...|..::.:..::|:|...:||
Human   624 LALLYEKIKIQQSVLNKGESQYNQRLEDMRILRLEIKKLRREKGILARSMANVEELRQEFFHMQR 688

  Fly   713 ALNQEHIRIRALTEDARTPTGVHRWRILKGEDPKKFELLEKLQLLQKRSLKQSIENSNLKNKLCE 777
            .|.:|..|.|||.|:...|..|||||.|:..||..:||::|:..||||.:.::.|....:..|.|
Human   689 ELLKERTRCRALEEELENPLNVHRWRKLEASDPNAYELIQKIHTLQKRLISKTEEVVEKELLLQE 753

  Fly   778 AQKTNETLKRMLSHMPTVEIKHKLVVQQRINRQMAKKLKTLAAERSLDMVELKSRQ 833
            .:|....||.:|:..|..|...:|.:.:|......::||.|::|  |:|.|::|::
Human   754 KEKLYMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSE--LNMYEVQSKE 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ORY	NP_001015498.5	SMC_N	<111..435	CDD:481474	83/351 (24%)
		DR0291	290..>417	CDD:441187	32/128 (25%)
		SMC_prok_B	<363..686	CDD:274008	88/329 (27%)
CFAP58	NP_001008723.1	Smc	<191..>737	CDD:440809	152/576 (26%)