DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp1-Y2 and PPEF1

DIOPT Version :9

Sequence 1:	NP_001015497.4	Gene:	Pp1-Y2 / 3355173	FlyBaseID:	FBgn0046698	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	NP_001364915.1	Gene:	PPEF1 / 5475	HGNCID:	9243	Length:	653	Species:	Homo sapiens

Alignment Length:	336	Identity:	98/336 - (29%)
Similarity:	154/336 - (45%)	Gaps:	76/336 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QLNLTETDIRLLCNRSRE------------VFMSQPMLLEL----------SAPVKICGDIHGQF 71
            |..||.|||.||....:|            :|.::.:|.::          |..|.||||:||:.
Human   113 QFPLTCTDIDLLLEAFKEQQILHAHYVLEVLFETKKVLKQMPNFTHIQTSPSKEVTICGDLHGKL 177

  Fly    72 TDLLRLFDYGGYPPASN-YLFLGDYVDRGKQSIETMCLLLAYKIKYPENFFLLRGNHESAGINRI 135
            .||..:|...|.|...| |:|.||:|||||.|||.:.:|....:.||.:..|.|||||...:|..
Human   178 DDLFLIFYKNGLPSERNPYVFNGDFVDRGKNSIEILMILCVSFLVYPNDLHLNRGNHEDFMMNLR 242

  Fly   136 YGFYDECKRRYTI---KLWRTFVDCYSCMPVSAIVDEKIFCCHGGLSPDLLNMNQIGQLAR---- 193
            |||..|...:|.:   ::.:...:.|:.:|:..|||.:|...|||:| :..::|.:.::.|
Human   243 YGFTKEILHKYKLHGKRILQILEEFYAWLPIGTIVDNEILVIHGGIS-ETTDLNLLHRVERNKMK 306

  Fly   194 -----PCDV----------------------------PDKGL-------LCDLLWSDPDPKIMGW 218
                 |.:.                            |.:.|       :.|:|||||..|...:
Human   307 SVLIPPTETNRDHDTDSKHNKVGVTFNAHGRIKTNGSPTEHLTEHEWEQIIDILWSDPRGKNGCF 371

  Fly   219 SDNDRGVSVTFGADIVGKFVHRHKFDLICRAHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGA 283
            .:..||....||.|:..|.:::::..::.|:|:...:|||.....:::|||||.||..|..|.||
Human   372 PNTCRGGGCYFGPDVTSKILNKYQLKMLIRSHECKPEGYEICHDGKVVTIFSASNYYEEGSNRGA 436

  Fly   284 MMSVDETLMCS 294
            .:.     :||
Human   437 YIK-----LCS 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp1-Y2	NP_001015497.4	PTZ00480	10..303	CDD:185658	98/336 (29%)
Pp1-Y2	NP_001015497.4	MPP_PP1_PPKL	13..300	CDD:277359	98/336 (29%)
PPEF1	NP_001364915.1	IQ	18..37	CDD:197470
		MPP_RdgC	115..452	CDD:277364	97/334 (29%)
		Catalytic	121..455		93/328 (28%)
		EF-hand_7	568..636	CDD:404394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910