DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pp1-Y2 and ppp5c

DIOPT Version :9

Sequence 1:	NP_001015497.4	Gene:	Pp1-Y2 / 3355173	FlyBaseID:	FBgn0046698	Length:	313	Species:	Drosophila melanogaster
Sequence 2:	XP_005157433.1	Gene:	ppp5c / 541536	ZFINID:	ZDB-GENE-050327-75	Length:	489	Species:	Danio rerio

Alignment Length:	271	Identity:	108/271 - (39%)
Similarity:	165/271 - (60%)	Gaps:	12/271 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 REVFMSQPMLLEL----SAPVKICGDIHGQFTDLLRLFDYGGYP-PASNYLFLGDYVDRGKQSIE 104
            :||....|.|:|:    |..:.||||.|||:.|||.:|:....| |.:.|||.||:||||..|:|
Zfish   207 KEVLTKLPSLVEITLKESEKITICGDTHGQYYDLLNIFELNSLPSPTNPYLFNGDFVDRGSFSVE 271

  Fly   105 TMCLLLAYKIKYPENFFLLRGNHESAGINRIYGFYDECKRRYTIKLWRTFVDCYSCMPVSAIVDE 169
            .:..|..:|:.|||:|.|||||||:..:|::|||..|.|.:|:.::::.|.:.:..:|::..:::
Zfish   272 VILTLFGFKLLYPEHFHLLRGNHETDNMNQMYGFEGEVKAKYSSQMFKLFSEVFQWLPLAQCIND 336

  Fly   170 KIFCCHGGL-SPDLLNMNQIGQLARPCDVPDKGLLCDLLWSDPDPKIMGWSDNDRGVSVTFGADI 233
            |:...|||| |.|.:.::.|.::.|....||.|.:||||||||..: .|.|.:.||||..||.|:
Zfish   337 KVLVMHGGLFSEDGVTLDDIRKIDRNRQPPDSGPMCDLLWSDPQLQ-NGRSISKRGVSCQFGPDV 400

  Fly   234 VGKFVHRHKFDLICRAHQVVEDGYEFFAKRQLITIFSAPNYCGEFDNAGAMMSV-DETLMCSFY- 296
            ..:|:.::|.:.|.|:|:|..:|||.....:.||:|||||||.:..|.||.:.: ...|...|:
Zfish   401 TERFLEQNKLEYIVRSHEVKAEGYEVTHSGKCITVFSAPNYCDQMGNKGAYIHLRGSDLKPEFHQ 465

  Fly   297 ---VLKPSKKP 304
               |..|:.||
Zfish   466 FTAVPHPNVKP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pp1-Y2	NP_001015497.4	PTZ00480	10..303	CDD:185658	106/268 (40%)
Pp1-Y2	NP_001015497.4	MPP_PP1_PPKL	13..300	CDD:277359	105/265 (40%)
ppp5c	XP_005157433.1	BamD	17..>149	CDD:276939
		TPR_11	17..83	CDD:290150
		TPR repeat	18..46	CDD:276939
		TPR repeat	18..46	CDD:276809
		TPR repeat	51..81	CDD:276809
		TPR repeat	55..81	CDD:276939
		TPR_9	62..124	CDD:290108
		TPR repeat	84..116	CDD:276939
		TPR repeat	86..114	CDD:276809
		MPP_PP5_C	166..481	CDD:277362	108/271 (40%)
		PP2Ac	194..470	CDD:197547	104/263 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910