Protein Alignment Pp1-Y2 and Ppp3cc

DIOPT Version :10

• Sequence 1: NP_001015497.4
• Gene: Pp1-Y2 / 3355173
• FlyBaseID: FBgn0046698
• Length: 313
• Species: Drosophila melanogaster
• Sequence 2: NP_001291920.1
• Gene: Ppp3cc / 19057
• MGIID: 107162
• Length: 522
• Species: Mus musculus
• Alignment Length: 224
• Identity: 40/224 - (17%)
• Similarity: 78/224 - (34%)
• Gaps: 68/224 - (30%)

  Fly    65 ELESYDAETEKEPKQPI-NFNVDFSANASSQFAGKGGDEYAEELSAAFQAAYSKALDIMPNLAKT 128
            :.|:.|:.|:..|:..: ..:::.|.:...|.|.: |:::.|:..|.     .|..:..|:.||
Mouse   588 QAEAEDSGTQDSPEAGVEKSDLEMSEDTDKQEATE-GEQFGEDAKAE-----DKPQENEPDRAK- 645

  Fly   129 QLADGYRWKINVDISVLQWDGSVSDAISIAII---GALSDLEFPEGDVAPDDGGKVRIVLKRPKV 190
                                 |:.:.::.||:   ...|:.||.:.....|:|..|    |..:.
Mouse   646 ---------------------SMQEKLAEAILKESQCSSEPEFSDTSTEEDEGASV----KTQQD 685

  Fly   191 AGNVRDENVQVAMWKLDVMRCPLLLTISKIGTANLVDCTPEEECCIRSQLLVGLAAIADSSENNE 255
            ...|..|                    |.:|..:....|.::|..:.|:     .|...:.:.||
Mouse   686 GQGVESE--------------------SAVGFTSPQPSTTQDEIAVESE-----EAKQSAEDKNE 725

  Fly   256 PNYDVTCVKQVGGGLLEMESIQEMLELAA 284
            ...:|...:       |.:.|.|..:.||
Mouse   726 QEPEVHTEE-------ERQEIDETTDAAA 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pp1-Y2	NP_001015497.4	MPP_PP1_PPKL	13..300	CDD:277359	40/224 (18%)
Ppp3cc	NP_001291920.1	MPP_PP2B	37..341	CDD:277361
		Catalytic. /evidence=ECO:0000305	52..343
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	394..408
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	409..416
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	467..489
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..522