Protein Alignment FucTC and POFUT3

DIOPT Version :10

• Sequence 1: NP_001036320.3
• Gene: FucTC / 3355171
• FlyBaseID: FBgn0044872
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: XP_011542978.1
• Gene: POFUT3 / 84750
• HGNCID: 19234
• Length: 604
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 107/487 - (21%)
• Similarity: 163/487 - (33%)
• Gaps: 153/487 - (31%)

  Fly    34 CGPRGALLLLLLVLLGVLVVLHKVT---------------QSPLLNQNKILQDHLR------GQH 77
            |......||:.|..|..:..|.|||               |.||.|...  .:|::      |:.
Human    15 CVTATVFLLVTLQALDTVENLMKVTGPPQGVTDSMQCFNDQRPLSNTRS--SEHIKEVMVELGKF 77

  Fly    78 ER------YIQSTRT--------------------------------ILLWTEFFGDSRWK-LSW 103
            ||      .:|...|                                |:||        |. |:.
Human    78 ERKEFKSSSLQDGHTKMEEAPTHLNSFLKKEGLTFNRKRKWELDSYPIMLW--------WSPLTG 134

  Fly   104 DT--LGPQELRDELHCPVYQCEISNQNAFLPAVELYDAIVFHAAEMFPLLRPVPSQRSPHQVYVF 166
            :|  ||        .|....|..:....:|.. .:..|.:|:..:......|:| :::.|...||
Human   135 ETGRLG--------QCGADACFFTINRTYLHH-HMTKAFLFYGTDFNIDSLPLP-RKAHHDWAVF 189

  Fly   167 ALMEPPGETKHRLDDEQGFYNLTMTYRIDSDVFWPYGQLLDITADAVVAPSVKPPWR-KPPVAFN 230
            ....|....|.........:|.|.|:...|.        |.:|...:.:..|....| ..|:...
Human   190 HEESPKNNYKLFHKPVITLFNYTATFSRHSH--------LPLTTQYLESIEVLKSLRYLVPLQSK 246

  Fly   231 DSLVWDLWSGKTKTAAWFVSHCETLSKREVLANRLQEFFEVDIYGNC---GTLSCTRGDPHCAEM 292
            :.|     ..:.....:..|.|:..|.|:.....|..:.|||.||.|   ..|.....:|   ..
Human   247 NKL-----RKRLAPLVYVQSDCDPPSDRDSYVRELMTYIEVDSYGECLRNKDLPQQLKNP---AS 303

  Fly   293 LDTD--------YFFYLAFENSLCDDYVTEKLFDALERTVIPVVFGGADYSRILPPH-SYVDANR 348
            :|.|        |.|.|||||::||||:|||.:..|:..|:||.:|....:..||.: |.:..:.
Human   304 MDADGFYRIIAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPSITDWLPSNKSAILVSE 368

  Fly   349 FMSVEGLAQYMKLVVADPDLYVSYFWWR-----SHYRL-----------------TYSSPF-CDL 390
            |.....||.|::.:.:|..||.:|..|:     |:.||                 .|...| |.:
Human   369 FSHPRELASYIRRLDSDDRLYEAYVEWKLKGEISNQRLLTALRERKWGVQDVNQDNYIDAFECMV 433

  Fly   391 CARLHDPSFGHKTQFYHDIQSWWFNSCRLQSR 422
            |.::                  |.| .|||.:
Human   434 CTKV------------------WAN-IRLQEK 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FucTC	NP_001036320.3	Glyco_tran_10_N	82..203	CDD:465336	26/155 (17%)
		Glyco_transf_10	238..412	CDD:459962	53/208 (25%)
POFUT3	XP_011542978.1	Glyco_tran_10_N	125..219	CDD:465336	23/111 (21%)
		Glyco_transf_10	243..>396	CDD:459962	46/160 (29%)