Protein Alignment FucTC and FUT6

DIOPT Version :10

• Sequence 1: NP_001036320.3
• Gene: FucTC / 3355171
• FlyBaseID: FBgn0044872
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_000141.1
• Gene: FUT6 / 2528
• HGNCID: 4017
• Length: 359
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 121/401 - (30%)
• Similarity: 174/401 - (43%)
• Gaps: 89/401 - (22%)

  Fly    40 LLLLLLVLLGVLVVLHKVTQSPLLNQNKILQDHLRGQHERYIQSTRT-------ILLWTEFFGDS 97
            ||..||:.:.....|......|.:..|          ..|:..||.|       |||||
Human    20 LLFQLLMAVCFFSYLRVSQDDPTVYPN----------GSRFPDSTGTPAHSIPLILLWT------ 68

  Fly    98 RWKLSWDTLGPQELRDELHCPVYQCEISNQNAFLPAVELYDAIVFHAAEMF--PLLRPVPSQRSP 160
             |..:.....|:  ..|:......|.|:......|..   ||::.|..|:.  |..:...|.|..
Human    69 -WPFNKPIALPR--CSEMVPGTADCNITADRKVYPQA---DAVIVHHREVMYNPSAQLPRSPRRQ 127

  Fly   161 HQVYVFALMEPPGETKHRLDDEQGFYNLTMTYRIDSDVFWPYGQLLDITADAVVAPSVKPPW--- 222
            .|.:::..||.|... .:|....|::||||:||.|||:|.|||.|              .||
Human   128 GQRWIWFSMESPSHC-WQLKAMDGYFNLTMSYRSDSDIFTPYGWL--------------EPWSGQ 177

  Fly   223 -RKPPVAFNDSLVWDLWSGKTKTAAWFVSHCETLSKREVLANRLQEFFEVDIYGNC------GTL 280
             ..||:..         |.||:..||.||:....|.|......||...:||:||..      ||
Human   178 PAHPPLNL---------SAKTELVAWAVSNWGPNSARVRYYQSLQAHLKVDVYGRSHKPLPQGT- 232

  Fly   281 SCTRGDPHCAEMLDT--DYFFYLAFENSLCDDYVTEKLF-DALERTVIPVVFG--GADYSRILPP 340
                       |::|  .|.|||||||||..||:||||: :|||...:|||.|  .::|.|.|||
Human   233 -----------MMETLSRYKFYLAFENSLHPDYITEKLWRNALEAWAVPVVLGPSRSNYERFLPP 286

  Fly   341 HSYVDANRFMSVEGLAQYMKLVVADPDLYVSYFWWRSHYR---LTYSSPFCDLCARLHDPSFGHK 402
            .:::..:.|.|.:.||:|::.:..|...|:|||.||...|   .:::..||..|.:|.:.| .::
Human   287 DAFIHVDDFQSPKDLARYLQELDKDHARYLSYFRWRETLRPRSFSWALAFCKACWKLQEES-RYQ 350

  Fly   403 TQFYHDIQSWW 413
            |:   .|.:|:
Human   351 TR---GIAAWF 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FucTC	NP_001036320.3	Glyco_tran_10_N	82..203	CDD:465336	38/129 (29%)
		Glyco_transf_10	238..412	CDD:459962	67/187 (36%)
FUT6	NP_000141.1	Glyco_tran_10_N	62..169	CDD:465336	35/119 (29%)
		determines site-specific fucosylation. /evidence=ECO:0000269|PubMed:17604274	73..112		8/43 (19%)
		Glyco_transf_10	185..357	CDD:459962	67/196 (34%)