Protein Alignment FucTC and POFUT4

DIOPT Version :10

• Sequence 1: NP_001036320.3
• Gene: FucTC / 3355171
• FlyBaseID: FBgn0044872
• Length: 425
• Species: Drosophila melanogaster
• Sequence 2: NP_775811.2
• Gene: POFUT4 / 170384
• HGNCID: 19233
• Length: 492
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 99/430 - (23%)
• Similarity: 148/430 - (34%)
• Gaps: 149/430 - (34%)

  Fly    32 LACGPRGALLLLLLVLLGVLVVLHKVTQSPLLNQNKILQDHLRGQHERYIQSTRTILLWTEFFGD 96
            :|.||    :.::|||||||.|........:..:                          |..|:
Human     1 MAAGP----IRVVLVLLGVLSVCAASGHGSVAER--------------------------EAGGE 35

  Fly    97 SRWKLSWD--------TLG----------PQELRDE------------------------LHCPV 119
            :.|...||        .||          |:..|:|                        :.|..
Human    36 AEWAEPWDGAVFRPPSALGAVGVTRSSGTPRPGREEAGDLPVLLWWSPGLFPHFPGDSERIECAR 100

  Fly   120 YQCEIS-NQNAFLPAVELYD----AIVFHAAEMFPLLRPVPSQRSPHQVYV----------FALM 169
            ..|..| |:.|      |.|    |::|:..:......|:|  |..||.:.          |.|.
Human   101 GACVASRNRRA------LRDSRTRALLFYGTDFRASAAPLP--RLAHQSWALLHEESPLNNFLLS 157

  Fly   170 EPPGETKHRLDDEQGFYNLTMTYRIDSDVFWPYGQLLDITADAVVAPSVKPP-----WRKPPVAF 229
            ..||   .||      :|||.|:...||  :|. .|..:...|.:...|.||     ||:...|
Human   158 HGPG---IRL------FNLTSTFSRHSD--YPL-SLQWLPGTAYLRRPVPPPMERAEWRRRGYA- 209

  Fly   230 NDSLVWDLWSGKTKTAAWFVSHCETLSKREVLANRLQEFFEVDIYGNC------------GTLSC 282
                          ...:..|||:..:.|:.....|.....||.||.|            .|.:.
Human   210 --------------PLLYLQSHCDVPADRDRYVRELMRHIPVDSYGKCLQNRELPTARLQDTATA 260

  Fly   283 TRGDPHCAEMLDTDYFFYLAFENSLCDDYVTEKLFDALERTVIPVVFGGADYSRILP-PHSYVDA 346
            |..||.....| :.|.|:||.||::|:||:||||:..:....:||..|.......:| .||.:..
Human   261 TTEDPELLAFL-SRYKFHLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILI 324

  Fly   347 NRFMSVEGLAQYMKLVVADPDLYVSYFWWRSHYRLTYSSP 386
            :.|.|.:.||:::..:..:.:.|:.|        |.|..|
Human   325 DDFESPQKLAEFIDFLDKNDEEYMKY--------LAYKQP 356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FucTC	NP_001036320.3	Glyco_tran_10_N	82..203	CDD:465336	37/177 (21%)
		Glyco_transf_10	238..412	CDD:459962	43/162 (27%)
POFUT4	NP_775811.2	Glyco_tran_10_N	77..176	CDD:465336	24/115 (21%)
		Glyco_transf_10	216..>355	CDD:459962	42/147 (29%)