DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG40485 and DHRS11

DIOPT Version :9

Sequence 1:	NP_001036313.1	Gene:	CG40485 / 3355165	FlyBaseID:	FBgn0069973	Length:	247	Species:	Drosophila melanogaster
Sequence 2:	NP_077284.2	Gene:	DHRS11 / 79154	HGNCID:	28639	Length:	260	Species:	Homo sapiens

Alignment Length:	264	Identity:	99/264 - (37%)
Similarity:	151/264 - (57%)	Gaps:	36/264 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MERWHNCVAVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREE----------LPQDRR 55
            ||||.:.:|:|||||.|||||:.|.|:..|:.||..||.:..:|:|..|          :|
Human     6 MERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIP---- 66

  Fly    56 SRLRIMQCDVSDVSSVNAVFDAVQGDLGNVDILINNAGKLSGGQLLTMSVDTVQQMLQTNVMGVV 120
                 .:||:|:...:.::|.|::.....|||.|||||......||:.|....:.|...||:.:.
Human    67 -----YRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALS 126

  Fly   121 YCTQRAFESMRQRQ-SKGHVVLINSIVGHYIFNPLPGSQQELNMYPATKHAITALTELFRQEMRD 184
            .||:.|::||::|. ..||::.|||:.||.:. ||    ...:.|.|||:|:|||||..|||:|:
Human   127 ICTREAYQSMKERNVDDGHIININSMSGHRVL-PL----SVTHFYSATKYAVTALTEGLRQELRE 186

  Fly   185 FKTKVKVTSISPGLVDT-----------ELVPLDYKGLPMLQAEDVANAIMYVLSTPPHVQVHEL 238
            .:|.::.|.||||:|:|           |.....|:.:..|:.||||.|::||||||.|:|:.::
Human   187 AQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVIYVLSTPAHIQIGDI 251

  Fly   239 TIKP 242
            .::|
Human   252 QMRP 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG40485	NP_001036313.1	YdfG	1..247	CDD:226674	99/264 (38%)
CG40485	NP_001036313.1	NADB_Rossmann	1..242	CDD:304358	98/262 (37%)
DHRS11	NP_077284.2	Mgc4172-like_SDR_c	6..256	CDD:187601	99/264 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143369
Domainoid	1	1.000	154	1.000	Domainoid score	I4257
eggNOG	1	0.900	-	-		E2759_KOG1205
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41560
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3916
Isobase	1	0.950	-	0	Normalized mean entropy	S2090
OMA	1	1.010	-	-		QHG45743
OrthoDB	1	1.010	-	-		D1190834at2759
OrthoFinder	1	1.000	-	-		FOG0000588
OrthoInspector	1	1.000	-	-		otm40752
orthoMCL	1	0.900	-	-		OOG6_100320
Panther	1	1.100	-	-	O	PTHR43115
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1880
SonicParanoid	1	1.000	-	-		X367
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.880