Protein Alignment CG40485 and RDH8

DIOPT Version :10

• Sequence 1: NP_001036313.1
• Gene: CG40485 / 3355165
• FlyBaseID: FBgn0069973
• Length: 247
• Species: Drosophila melanogaster
• Sequence 2: NP_056540.3
• Gene: RDH8 / 50700
• HGNCID: 14423
• Length: 311
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 70/276 - (25%)
• Similarity: 116/276 - (42%)
• Gaps: 62/276 - (22%)

  Fly    10 VVTGASSGIGAAITRKLI---SAGVMVVALARRMDRLEQLREELPQDRRSRLRIMQCDVSDVSSV 71
            :::|.|||||..:..:|.   .....|||..|.:.:.|.|.....:.....|.:.|.||....||
Human     9 LISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVCSDESV 73

  Fly    72 NAVFDAVQGDLGNVDILINNAGKLSGGQLLTMSVDTVQQMLQTNVMGVVYCTQRAFESMRQRQSK 136
            ......:||:   ||:|:||||....|.|..:|:..:|.:..||..|.|...:.....|::|: :
Human    74 AQCLSCIQGE---VDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRR-Q 134

  Fly   137 GHVVLINSIVG--HYIFNPLPGSQQELNMYPATKHAITALTELFRQEMRDFKTKVKVTSISPGLV 199
            ||:|:|:|::|  ..|||         ::|.|:|.|:....|....::..|  .:.::.:.||.|
Human   135 GHIVVISSVMGLQGVIFN---------DVYAASKFALEGFFESLAIQLLQF--NIFISLVEPGPV 188

  Fly   200 DTELVPLDYKGLPMLQA-----------------------------------EDVANAIMYVLST 229
            .||     ::|..:.|.                                   :||..||:.|:|:
Human   189 VTE-----FEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISS 248

  Fly   230 --PPHVQVHELTIKPL 243
              ||..:...:...||
Human   249 TRPPLRRQTNIRYSPL 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG40485	NP_001036313.1	Rossmann-fold NAD(P)(+)-binding proteins	1..242	CDD:473865	68/273 (25%)
RDH8	NP_056540.3	type1_17beta-HSD-like_SDR_c	6..262	CDD:187666	68/272 (25%)