Protein Alignment CG40485 and DHRS7B

DIOPT Version :10

• Sequence 1: NP_001036313.1
• Gene: CG40485 / 3355165
• FlyBaseID: FBgn0069973
• Length: 247
• Species: Drosophila melanogaster
• Sequence 2: XP_047291678.1
• Gene: DHRS7B / 25979
• HGNCID: 24547
• Length: 372
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 77/264 - (29%)
• Similarity: 128/264 - (48%)
• Gaps: 37/264 - (14%)

  Fly     6 NCVAVVTGASSGIGAAITRKLISAGVMVVALARRMDRLEQLREELPQDRRSRLR-----IMQCDV 65
            |.|.|:|||:||:|....:...:||..:|...|....||:|..||.....::::     ::..|:
Human    99 NAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDL 163

  Fly    66 SDVSSVNAVFDAVQGDLGNVDILINNAGKLSGGQLLTMSVDTVQQMLQTNVMGVVYCTQRAFESM 130
            :|..::.|....:....|.||||:||||....|.::..:||..:::::||..|.|..|:....||
Human   164 TDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSM 228

  Fly   131 RQRQSKGHVVLINSIVGHYIFNPLPGSQQELNMYPATKHAITALTELFRQEMRDFKTKVKVTSIS 195
            .:|: :||:|.|:||.|..       |....:.|.|:|||..|..:..|.||..:  :::||.||
Human   229 IKRR-QGHIVAISSIQGKM-------SIPFRSAYAASKHATQAFFDCLRAEMEQY--EIEVTVIS 283

  Fly   196 PGLVDTEL----VPLD---YKGL---------PMLQAEDVANAI------MYVLSTPPHVQVHEL 238
            ||.:.|.|    :..|   |..:         |:..|:||..|:      :.:....|.:.|:..
Human   284 PGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLR 348

  Fly   239 TIKP 242
            |:.|
Human   349 TLAP 352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG40485	NP_001036313.1	Rossmann-fold NAD(P)(+)-binding proteins	1..242	CDD:473865	76/262 (29%)
DHRS7B	XP_047291678.1	11beta-HSD1_like_SDR_c	97..358	CDD:187593	77/264 (29%)