Protein Alignment CG40485 and DHRS1

DIOPT Version :10

• Sequence 1: NP_001036313.1
• Gene: CG40485 / 3355165
• FlyBaseID: FBgn0069973
• Length: 247
• Species: Drosophila melanogaster
• Sequence 2: NP_612461.1
• Gene: DHRS1 / 115817
• HGNCID: 16445
• Length: 313
• Species: Homo sapiens
• Alignment Length: 303
• Identity: 54/303 - (17%)
• Similarity: 110/303 - (36%)
• Gaps: 94/303 - (31%)

  Fly    48 AHGVNSWPDLVDQLHEPFLNKSMMIEGDVFMQAHRRPRHRAVPVMKADTKLADRIT-FKEWLREV 111
            :|||.:..|::         ....:.|..|.:.     ..|..|:|...|..:..| :::.:|:|
Human   743 SHGVETIRDIL---------PDTSLGGPAFFKI-----ITAKAVLKLQAKNTEEATHWRDLVRKV 793

  Fly   112 -----ATMNKAIKINFRSNEVVRPVLQDLYASQADPTSPVLQYPVILHANVFRSPRSVETEVDPS 171
                 .:..:|:.:....:|..:.||:  :|::.:  ..:|||.|           ::.||
Human   794 LASYLESAEEAVTLGGSLDEKCQEVLK--FATREN--GFLLQYLV-----------AIPTE---- 839

  Fly   172 TFVEKAKDLFPDATLSLGWTKQSNFSHLHPK---FKKLSWRQLFH-------------------- 213
                  |.|........|.::|..||.:.||   |..|.:....|
Human   840 ------KGLDSQGCFCAGCSRQIGFSFVRPKLCAFSGLYYCDFCHQDDASVIPARIIHNWDLTKR 898

  Fly   214 -----ILEYISRLDQPVMLSVRL-SVAAHSKEQLLWLLGMDQSISLLLWSDAEDHVTNWTPIVEL 272
                 .|::::::....:::::| :.:.:...:.:.|:|..:. .|.|..|          .:.|
Human   899 PVCRQALKFLAQIRAQPLINLQLVNASLYEHVERMHLIGRSRE-QLKLLGD----------YLGL 952

  Fly   273 RRSTTKNRILYDLDPKHRKFLQTDSNEPIATPPTFSLQDWQAV 315
            .||.....:...|  .||.:|       :.:|..||:.|.|.:
Human   953 CRSGALKELCKRL--SHRNYL-------LESPHRFSVADLQQI 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG40485	NP_001036313.1	Rossmann-fold NAD(P)(+)-binding proteins	1..242	CDD:473865	37/228 (16%)
DHRS1	NP_612461.1	DHRS1-like_SDR_c	5..271	CDD:187664
		Required for ER localization. /evidence=ECO:0000269|PubMed:30031147	235..313