DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab21 and Rab21

DIOPT Version :9

Sequence 1:	NP_001036321.2	Gene:	Rab21 / 3355163	FlyBaseID:	FBgn0039966	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_001004238.1	Gene:	Rab21 / 299799	RGDID:	1303150	Length:	223	Species:	Rattus norvegicus

Alignment Length:	223	Identity:	117/223 - (52%)
Similarity:	152/223 - (68%)	Gaps:	26/223 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GPTLNFKAVLLGEGCVGKTSLVLRYMEDRFNAQHLSTLQASFVSRKMSLEDGRRAQLNIWDTAGQ 73
            |...:||.|||||||||||||||||.|::||.:|::||||||:::|::: .|:|..|.|||||||
  Rat    13 GRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNI-GGKRVNLAIWDTAGQ 76

  Fly    74 ERFHALGPIYYRGSDGALLVYDITDRDSFQKVKSWVRELRQMRGTEIALIIVGNKTDLEEQRAVT 138
            ||||||||||||.|:||:||||:||.|||||||:||:|||:|.|.||.|.|||||.|||::|.|:
  Rat    77 ERFHALGPIYYRDSNGAILVYDVTDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVS 141

  Fly   139 HDEALQYARTVGAQYVETSAKENEGVAELFELLTQLMLE--QLSQRQPDASPLRLQNPDTDNLNN 201
            ..||..||.:|||::..||||:|:|:.|||..|.:.|:|  |:.:|...              |.
  Rat   142 IQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKG--------------NG 192

  Fly   202 SDDSEA---------PDPGDPAGQRSCC 220
            |..:.|         .:|...:|...||
  Rat   193 SSQAGAARRGVQIIDDEPQAQSGSGGCC 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab21	NP_001036321.2	Rab21	14..176	CDD:133323	105/161 (65%)
Rab21	NP_001036321.2	Ras	15..177	CDD:278499	105/161 (65%)
Rab21	NP_001004238.1	Rab21	18..179	CDD:133323	105/160 (66%)
Rab21	NP_001004238.1	Effector region. /evidence=ECO:0000250	46..54		5/7 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354084
Domainoid	1	1.000	214	1.000	Domainoid score	I2660
eggNOG	1	0.900	-	-		E1_KOG0088
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8991
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3465
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1226895at2759
OrthoFinder	1	1.000	-	-		FOG0006095
OrthoInspector	1	1.000	-	-		oto97703
orthoMCL	1	0.900	-	-		OOG6_103363
Panther	1	1.100	-	-	LDO	PTHR24073
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4390
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760