DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab21 and RAB21

DIOPT Version :9

Sequence 1:	NP_001036321.2	Gene:	Rab21 / 3355163	FlyBaseID:	FBgn0039966	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_055814.1	Gene:	RAB21 / 23011	HGNCID:	18263	Length:	225	Species:	Homo sapiens

Alignment Length:	221	Identity:	120/221 - (54%)
Similarity:	155/221 - (70%)	Gaps:	22/221 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GPTLNFKAVLLGEGCVGKTSLVLRYMEDRFNAQHLSTLQASFVSRKMSLEDGRRAQLNIWDTAGQ 73
            |...:||.|||||||||||||||||.|::||.:|::||||||:::|::: .|:|..|.|||||||
Human    15 GRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNI-GGKRVNLAIWDTAGQ 78

  Fly    74 ERFHALGPIYYRGSDGALLVYDITDRDSFQKVKSWVRELRQMRGTEIALIIVGNKTDLEEQRAVT 138
            ||||||||||||.|:||:|||||||.|||||||:||:|||:|.|.||.|.|||||.|||::|.|:
Human    79 ERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVS 143

  Fly   139 HDEALQYARTVGAQYVETSAKENEGVAELFELLTQLMLE--QLSQR-------QPDASPLRLQNP 194
            ..||..||.:|||::..||||:|:|:.|||..|.:.|:|  |:.:|       ||..:...:|..
Human   144 IQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQPGTARRGVQII 208

  Fly   195 DTDNLNNSDDSEAPDPGDPAGQRSCC 220
            |       |:.:|...|.     .||
Human   209 D-------DEPQAQTSGG-----GCC 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab21	NP_001036321.2	Rab21	14..176	CDD:133323	106/161 (66%)
Rab21	NP_001036321.2	Ras	15..177	CDD:278499	106/161 (66%)
RAB21	NP_055814.1	Rab21	20..181	CDD:133323	106/161 (66%)
RAB21	NP_055814.1	Ras	21..182	CDD:278499	106/161 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160015
Domainoid	1	1.000	215	1.000	Domainoid score	I2711
eggNOG	1	0.900	-	-		E1_KOG0088
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8991
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3558
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1226895at2759
OrthoFinder	1	1.000	-	-		FOG0006095
OrthoInspector	1	1.000	-	-		oto90589
orthoMCL	1	0.900	-	-		OOG6_103363
Panther	1	1.100	-	-	LDO	PTHR24073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3888
SonicParanoid	1	1.000	-	-		X4390
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790