DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab21 and rab-21

DIOPT Version :9

Sequence 1:	NP_001036321.2	Gene:	Rab21 / 3355163	FlyBaseID:	FBgn0039966	Length:	222	Species:	Drosophila melanogaster
Sequence 2:	NP_495854.1	Gene:	rab-21 / 187932	WormBaseID:	WBGene00004279	Length:	207	Species:	Caenorhabditis elegans

Alignment Length:	213	Identity:	106/213 - (49%)
Similarity:	149/213 - (69%)	Gaps:	19/213 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TLNFKAVLLGEGCVGKTSLVLRYMEDRFNAQHLSTLQASFVSRKMSLEDGRRAQLNIWDTAGQER 75
            :..||.||||||||||:|||||::|::|:.:||||:||||.::.:::|| .:|.|:||||||||:
Worm    10 SFKFKIVLLGEGCVGKSSLVLRFVENKFSCKHLSTIQASFQNKTVNVED-CQADLHIWDTAGQEK 73

  Fly    76 FHALGPIYYRGSDGALLVYDITDRDSFQKVKSWVRELRQMRGTEIALIIVGNKTDLEEQRAVTHD 140
            :|||||||||||:|.|||:|||||.||:|||:||.|::...|....::|||||.||||:|.||..
Worm    74 YHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNTAEILIVGNKIDLEEERQVTRQ 138

  Fly   141 EALQYARTVGAQYVETSAKENEGVAELFELLTQLMLEQLSQRQPDASPLRLQNPDTD---NLNNS 202
            :|..||.:.||.|:||||::|.|:::.||.||..|:|....|..:.       |.|:   .|.::
Worm   139 DAEAYAESEGALYMETSAQDNVGISDAFESLTAKMIEHSRTRSTEP-------PSTNRSIRLIDN 196

  Fly   203 DDSEAPDPGDPAGQRSCC 220
            |::|.        .:.||
Worm   197 DEAER--------SKKCC 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab21	NP_001036321.2	Rab21	14..176	CDD:133323	96/161 (60%)
Rab21	NP_001036321.2	Ras	15..177	CDD:278499	96/161 (60%)
rab-21	NP_495854.1	Rab21	13..174	CDD:133323	96/161 (60%)
rab-21	NP_495854.1	Ras	14..175	CDD:278499	96/161 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167529
Domainoid	1	1.000	199	1.000	Domainoid score	I1788
eggNOG	1	0.900	-	-		E1_KOG0088
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8991
Inparanoid	1	1.050	207	1.000	Inparanoid score	I2410
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1226895at2759
OrthoFinder	1	1.000	-	-		FOG0006095
OrthoInspector	1	1.000	-	-		oto20179
orthoMCL	1	0.900	-	-		OOG6_103363
Panther	1	1.100	-	-	LDO	PTHR24073
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3888
SonicParanoid	1	1.000	-	-		X4390
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.830