Protein Alignment CG40486 and HSD11B1L

DIOPT Version :10

• Sequence 1: NP_001036311.2
• Gene: CG40486 / 3355162
• FlyBaseID: FBgn0263830
• Length: 247
• Species: Drosophila melanogaster
• Sequence 2: NP_001254797.1
• Gene: HSD11B1L / 374875
• HGNCID: 30419
• Length: 333
• Species: Homo sapiens
• Alignment Length: 255
• Identity: 54/255 - (21%)
• Similarity: 95/255 - (37%)
• Gaps: 52/255 - (20%)

  Fly     4 WHDRV---------AVVTGASSGIGAAVARHLVSAGVIVVGLARRVDRMKAIKEQLPPELQG--- 56
            |.|..         .::|||::|:|..:|.|....|..:|        :.|..|.|..::.|
Human    65 WDDNFDPASLQGARVLLTGANAGVGEELAYHYARLGSHLV--------LTAHTEALLQKVVGNCR 121

  Fly    57 -----RLHAIHCDVEDLDSVTAAFDWIEEQLGGCDILVNNAGCLNPGQLLTLELEQLQQVLNVNL 116
                 ::..|..|:...::..:...:..::|||.|.||.|.....|........:..:.::.||.
Human   122 KLGAPKVFYIAADMASPEAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQATRWLMQVNF 186

  Fly   117 MGVVICTRRAFRSMQQREVDGHVILINSLTGR--NIINPPGDELQVLNMYPLTKHGVTAMLEVLR 179
            :..|..|.||..|:...:  |.:::::||.||  ...:.|         |...|..:......||
Human   187 VSYVQLTSRALPSLTDSK--GSLVVVSSLLGRVPTSFSTP---------YSAAKFALDGFFGSLR 240

  Fly   180 QEL-------------RGFKTKIKVTSITPGVTDTEILPSGYGILPMLKPDDI-AAGIMY 225
            :||             .|.:.:........|||..:..|.....|.:::.... |||:.|
Human   241 RELDVQDVNVAITMCVLGLRDRASAAEAVRGVTRVKAAPGPKAALAVIRGGATRAAGVFY 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG40486	NP_001036311.2	Rossmann-fold NAD(P)(+)-binding proteins	1..242	CDD:473865	54/255 (21%)
HSD11B1L	NP_001254797.1	Rossmann-fold NAD(P)(+)-binding proteins	74..302	CDD:473865	52/246 (21%)