DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42346 and FLS2

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_001330009.1	Gene:	FLS2 / 834676	AraportID:	AT5G46330	Length:	1173	Species:	Arabidopsis thaliana

Alignment Length:	975	Identity:	227/975 - (23%)
Similarity:	380/975 - (38%)	Gaps:	237/975 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 YSFYGLRISKLNMKGNRLQGMPEHAFAGLEECMQEIDVSENGLRTFPLMALRKLDHLRILRLSNN 431
            :.|:|:.::|.:.:       ||         ::.:...:||:...||..|.....:..||..|
plant    15 FFFFGIALAKQSFE-------PE---------IEALKSFKNGISNDPLGVLSDWTIIGSLRHCN- 62

  Fly   432 RIPTFYGDIQLATNNASAAAAAVGAFQ-------------LPSLIFLDLSSNQF-----AEIGPD 478
                :.|    .|.:::....:|...:             |..|..|||:||.|     ||||
plant    63 ----WTG----ITCDSTGHVVSVSLLEKQLEGVLSPAIANLTYLQVLDLTSNSFTGKIPAEIG-- 117

  Fly   479 CFRAFPQLKTLSFYANQIELVQPEAFKSLRELMSLDMSHNRIIGLDPKVFEKNKRLQTVDLSHNH 543
               ...:|..|..|.|......|.....|:.:..||:.:|.:.|..|:...|...|..:...:|:
plant   118 ---KLTELNQLILYLNYFSGSIPSGIWELKNIFYLDLRNNLLSGDVPEEICKTSSLVLIGFDYNN 179

  Fly   544 I-HTIGGVFSNLPQLREVFLSENNIL--ELPADAFT--NSTNVDVIYLESNAIAHIDPNVFSTLV 603
            : ..|.....:|..| ::|::..|.|  .:|....|  |.|::|   |..|.:....|..|..|:
plant   180 LTGKIPECLGDLVHL-QMFVAAGNHLTGSIPVSIGTLANLTDLD---LSGNQLTGKIPRDFGNLL 240

  Fly   604 NLDHLYLRSNFIPLLPVTLFDKSTKLTSLSLDNNEIQDLEIGMFRKLEHLREVRLHNNRIRRVRR 668
            ||..|.|..|.:                    ..:| ..|||   ....|.::.|::|::.....
plant   241 NLQSLVLTENLL--------------------EGDI-PAEIG---NCSSLVQLELYDNQLTGKIP 281

  Fly   669 GVFEPLPSLQELHIQKNSIEDIEPQAFHTLENMQHINLQDNQLTVLEDIFPDENSSLLSVQLEAN 733
            .....|..||.|.|.||.:....|.:...|..:.|:.|.:|.|     :.|        :..|..
plant   282 AELGNLVQLQALRIYKNKLTSSIPSSLFRLTQLTHLGLSENHL-----VGP--------ISEEIG 333

  Fly   734 YLHKVHPRTFSRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYLSDNKIRDIEKDTFVNLLLLQ 798
            :|           :.::::.|..|       :|..:.||      |...:|::      .:|.:.
plant   334 FL-----------ESLEVLTLHSN-------NFTGEFPQ------SITNLRNL------TVLTVG 368

  Fly   799 FLDLSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIF 863
            |.::||    :|..| ...|.:|..||...|.:......:.:....||.||||||   |:|.:|
plant   369 FNNISG----ELPAD-LGLLTNLRNLSAHDNLLTGPIPSSISNCTGLKLLDLSHN---QMTGEI- 424

  Fly   864 SNEFPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLERNQLN---PADIQTLDIPNLRRLLLSHNN 925
                                ...|..: ||..:::.||...   |.||  .:..||..|.::.||
plant   425 --------------------PRGFGRM-NLTFISIGRNHFTGEIPDDI--FNCSNLETLSVADNN 466

  Fly   926 FSYAGSVGIMAGMLDRLRSLQQLSMSNCSL-GQIP-DLLFAKNTNLVRLDLCDNRLT-QINRNIF 987
            .:  |::..:.|.|.:||.||   :|..|| |.|| ::...|:.|:  |.|..|..| :|.|.:
plant   467 LT--GTLKPLIGKLQKLRILQ---VSYNSLTGPIPREIGNLKDLNI--LYLHSNGFTGRIPREM- 523

  Fly   988 SGLNVFKELRLCRNELSDFPHIALYNLSTLESLDLARN----QLASIDFFKLSGTLNLRQLILRD 1048
            |.|.:.:.||:..|:|.......::::..|..|||:.|    |:.:: |.||.   :|..|.|:.
plant   524 SNLTLLQGLRMYSNDLEGPIPEEMFDMKLLSVLDLSNNKFSGQIPAL-FSKLE---SLTYLSLQG 584

  Fly  1049 NKITALSGFNAVNLTQLDSVDLSGNLLL-SLPANFLRHSINLQ-KVHLSNNRFLQIPSSALSDVS 1111
            ||.......:..:|:.|::.|:|.|||. ::|...|....|:| .::.|||.
plant   585 NKFNGSIPASLKSLSLLNTFDISDNLLTGTIPGELLASLKNMQLYLNFSNNL------------- 636

  Fly  1112 IPRLSWLNLTGNPINRIYTVKEERYPYLKELYICQTNLSILTSKDFEAFQALQHLHLVNNRITRI 1176
                    |||.                             ..|:....:.:|.:.|.||..:..
plant   637 --------LTGT-----------------------------IPKELGKLEMVQEIDLSNNLFSGS 664

  Fly  1177 SPGAFKSLTNLLTLDLSVNELE-MLPKERLQGLRLLRFLNISHNTLK-DLEEFSVDLLEMQTLDL 1239
            .|.:.::..|:.|||.|.|.|. .:|.|..||:.::..||:|.|:.. ::.:...::..:.:|||
plant   665 IPRSLQACKNVFTLDFSQNNLSGHIPDEVFQGMDMIISLNLSRNSFSGEIPQSFGNMTHLVSLDL 729

  Fly  1240 SFNQLDRISKKTFRNLHGLLELFLMGNRMT--VLSNDAFRFLRKLHVLDLRKNYFELVPLEPLRP 1302
            |.|.|.....::..||..|..|.|..|.:.  |..:..|   :.::..||..|.......:||:|
plant   730 SSNNLTGEIPESLANLSTLKHLKLASNNLKGHVPESGVF---KNINASDLMGNTDLCGSKKPLKP 791

Fly 1303 1302
plant 792 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566	3/16 (19%)
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380	17/106 (16%)
		LRR_8	373..433	CDD:290566	11/59 (19%)
		LRR_RI	397..648	CDD:238064	62/273 (23%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	462..485	CDD:275380	11/27 (41%)
		LRR_8	465..520	CDD:290566	19/59 (32%)
		leucine-rich repeat	486..509	CDD:275380	6/22 (27%)
		LRR_8	508..567	CDD:290566	12/59 (20%)
		leucine-rich repeat	510..533	CDD:275380	6/22 (27%)
		LRR_RI	527..785	CDD:238064	53/262 (20%)
		leucine-rich repeat	534..556	CDD:275380	4/22 (18%)
		LRR_8	555..613	CDD:290566	18/61 (30%)
		leucine-rich repeat	557..580	CDD:275380	7/26 (27%)
		leucine-rich repeat	581..604	CDD:275380	6/22 (27%)
		LRR_8	604..663	CDD:290566	12/58 (21%)
		leucine-rich repeat	605..628	CDD:275380	4/22 (18%)
		leucine-rich repeat	629..652	CDD:275380	4/22 (18%)
		LRR_8	652..711	CDD:290566	15/58 (26%)
		leucine-rich repeat	653..676	CDD:275380	4/22 (18%)
		leucine-rich repeat	677..700	CDD:275380	8/22 (36%)
		leucine-rich repeat	701..748	CDD:275380	7/46 (15%)
		leucine-rich repeat	725..736	CDD:275378	1/10 (10%)
		leucine-rich repeat	749..772	CDD:275380	3/22 (14%)
		LRR_8	771..831	CDD:290566	15/59 (25%)
		leucine-rich repeat	773..793	CDD:275380	2/19 (11%)
		LRR_RI	804..1076	CDD:238064	79/281 (28%)
		LRR_8	821..903	CDD:290566	20/81 (25%)
		leucine-rich repeat	821..844	CDD:275380	4/22 (18%)
		leucine-rich repeat	845..868	CDD:275380	11/22 (50%)
		leucine-rich repeat	869..892	CDD:275380	1/22 (5%)
		leucine-rich repeat	893..915	CDD:275380	6/24 (25%)
		leucine-rich repeat	916..944	CDD:275380	8/27 (30%)
		leucine-rich repeat	945..968	CDD:275380	9/24 (38%)
		LRR_8	967..1027	CDD:290566	18/64 (28%)
		leucine-rich repeat	969..992	CDD:275380	8/23 (35%)
		leucine-rich repeat	993..1014	CDD:275380	4/20 (20%)
		LRR_8	1015..1075	CDD:290566	19/63 (30%)
		leucine-rich repeat	1017..1040	CDD:275380	9/26 (35%)
		leucine-rich repeat	1041..1064	CDD:275380	6/22 (27%)
		LRR_RI	<1047..1244	CDD:238064	45/200 (23%)
		LRR_8	1063..1125	CDD:290566	16/63 (25%)
		leucine-rich repeat	1089..1114	CDD:275380	4/25 (16%)
		leucine-rich repeat	1115..1162	CDD:275380	4/46 (9%)
		LRR_8	1163..1219	CDD:290566	19/56 (34%)
		leucine-rich repeat	1163..1186	CDD:275380	5/22 (23%)
		leucine-rich repeat	1187..1210	CDD:275380	10/23 (43%)
		leucine-rich repeat	1211..1233	CDD:275380	4/22 (18%)
		leucine-rich repeat	1234..1257	CDD:275380	8/22 (36%)
		LRR_8	1235..1292	CDD:290566	17/58 (29%)
		leucine-rich repeat	1258..1279	CDD:275380	6/22 (27%)
		leucine-rich repeat	1282..1306	CDD:275380	6/21 (29%)
FLS2	NP_001330009.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I1746
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960