DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42346 and AT4G36180

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_195341.2	Gene:	AT4G36180 / 829775	AraportID:	AT4G36180	Length:	1136	Species:	Arabidopsis thaliana

Alignment Length:	839	Identity:	210/839 - (25%)
Similarity:	325/839 - (38%)	Gaps:	162/839 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 HSHLEALK--DNSLRNVRSSLESLSIVNGKLTQ--MPSRALSSMQKLTALDFDYNEIVRVDDYSF 369
            |..|.||.  |.|..........:...|.::|:  :|...||.               |:.| ..
plant    40 HDPLGALTSWDPSTPAAPCDWRGVGCTNHRVTEIRLPRLQLSG---------------RISD-RI 88

  Fly   370 YGLR-ISKLNMKGNRLQG-MPEHAFAGLEECMQEIDV--SENGLRTFPLMALRKLDHLRILRLSN 430
            .||| :.||:::.|...| :|    ..|..|.:.:.|  ..|.|......|:|.|..|.:..::.
plant    89 SGLRMLRKLSLRSNSFNGTIP----TSLAYCTRLLSVFLQYNSLSGKLPPAMRNLTSLEVFNVAG 149

  Fly   431 NRIPTFYGDIQLATNNASAAAAAVGAFQLP-SLIFLDLSSNQFAEIGPDCFRAFPQLKTLSFYAN 494
            ||:.   |:|.:.               || ||.|||:|||.|:...|.......||:.|:...|
plant   150 NRLS---GEIPVG---------------LPSSLQFLDISSNTFSGQIPSGLANLTQLQLLNLSYN 196

  Fly   495 QIELVQPEAFKSLRELMSLDMSHNRIIGLDPKVFEKNKRLQTVDLSHNHIHTIGGV----FSNLP 555
            |:....|.:..:|:.|..|.:..|.:.|..|........|..:..|.|.   ||||    :..||
plant   197 QLTGEIPASLGNLQSLQYLWLDFNLLQGTLPSAISNCSSLVHLSASENE---IGGVIPAAYGALP 258

  Fly   556 QLREVFLSENNIL-ELPADAFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRSNFIPLLP 619
            :|..:.||.||.. .:|...|.| |::.::.|..||        ||.:|.              |
plant   259 KLEVLSLSNNNFSGTVPFSLFCN-TSLTIVQLGFNA--------FSDIVR--------------P 300

  Fly   620 VTLFDKSTKLTSLSLDNNEIQDLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQELHIQK 684
            .|..:..|.|..|.|..|.|.    |.|       .:.|.|             :.||:.|.:..
plant   301 ETTANCRTGLQVLDLQENRIS----GRF-------PLWLTN-------------ILSLKNLDVSG 341

  Fly   685 NSIEDIEPQAFHTLENMQHINLQDNQLTVLEDIFPDENSSLLSVQLEANYLHKVHPRTFSRQQKV 749
            |......|.....|:.::.:.|.:|.||....:...:..||..:..|.|.|....|......:.:
plant   342 NLFSGEIPPDIGNLKRLEELKLANNSLTGEIPVEIKQCGSLDVLDFEGNSLKGQIPEFLGYMKAL 406

  Fly   750 QIMWLKDNQLTRVERSFFADTPQLGRLYLSDNKIRDIEKDTFVNLLLLQFLDLSGNQLRQLRRDY 814
            :::.|..|..:....|...:..||.||.|.:|                   :|:|:...:|
plant   407 KVLSLGRNSFSGYVPSSMVNLQQLERLNLGEN-------------------NLNGSFPVEL---- 448

  Fly   815 FAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLNLGNCSL 879
             ..|..|.||.|:.|........:.:.|.||..|:||.|.        ||.|.|   .::||
plant   449 -MALTSLSELDLSGNRFSGAVPVSISNLSNLSFLNLSGNG--------FSGEIP---ASVGN--- 498

  Fly   880 RKLEQHAFKSLTNLNELNL-ERNQLNPADIQTLDIPNLRRLLLSHNNFSYAGSVGIMAGMLDRLR 943
                      |..|..|:| ::|......::...:||::.:.|..||||     |::......|.
plant   499 ----------LFKLTALDLSKQNMSGEVPVELSGLPNVQVIALQGNNFS-----GVVPEGFSSLV 548

  Fly   944 SLQQLSMSNCSL-GQIPDLLFAKNTNLVRLDLCDNRLTQINRNIFSGLNVFKELRLCRNELSDFP 1007
            ||:.:::|:.|. |:||. .|.....||.|.|.||.::..........:..:.|.|..|.|....
plant   549 SLRYVNLSSNSFSGEIPQ-TFGFLRLLVSLSLSDNHISGSIPPEIGNCSALEVLELRSNRLMGHI 612

  Fly  1008 HIALYNLSTLESLDLARNQLASIDFFKLSGTLNLRQLILRDNKITALSGFNAVNLTQLDSVDLS- 1071
            ...|..|..|:.|||.:|.|:.....::|.:.:|..|.|..|.::.:...:...|:.|..:|||
plant   613 PADLSRLPRLKVLDLGQNNLSGEIPPEISQSSSLNSLSLDHNHLSGVIPGSFSGLSNLTKMDLSV 677

  Fly  1072 GNLLLSLPANFLRHSINLQKVHLSNNRFL-QIPSSALSDV-SIPRLSW-LNLTGNPINR 1127
            .||...:||:....|.||...::|:|... :||:|..|.: :....|. ..|.|.|:||
plant   678 NNLTGEIPASLALISSNLVYFNVSSNNLKGEIPASLGSRINNTSEFSGNTELCGKPLNR 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380	6/17 (35%)
		LRR_8	325..384	CDD:290566	13/61 (21%)
		leucine-rich repeat	327..350	CDD:275380	5/24 (21%)
		leucine-rich repeat	351..461	CDD:275380	25/114 (22%)
		LRR_8	373..433	CDD:290566	16/63 (25%)
		LRR_RI	397..648	CDD:238064	69/258 (27%)
		leucine-rich repeat	399..422	CDD:275380	6/24 (25%)
		leucine-rich repeat	462..485	CDD:275380	9/22 (41%)
		LRR_8	465..520	CDD:290566	17/54 (31%)
		leucine-rich repeat	486..509	CDD:275380	6/22 (27%)
		LRR_8	508..567	CDD:290566	18/62 (29%)
		leucine-rich repeat	510..533	CDD:275380	5/22 (23%)
		LRR_RI	527..785	CDD:238064	61/262 (23%)
		leucine-rich repeat	534..556	CDD:275380	8/25 (32%)
		LRR_8	555..613	CDD:290566	16/58 (28%)
		leucine-rich repeat	557..580	CDD:275380	8/23 (35%)
		leucine-rich repeat	581..604	CDD:275380	5/22 (23%)
		LRR_8	604..663	CDD:290566	12/58 (21%)
		leucine-rich repeat	605..628	CDD:275380	2/22 (9%)
		leucine-rich repeat	629..652	CDD:275380	7/22 (32%)
		LRR_8	652..711	CDD:290566	10/58 (17%)
		leucine-rich repeat	653..676	CDD:275380	2/22 (9%)
		leucine-rich repeat	677..700	CDD:275380	5/22 (23%)
		leucine-rich repeat	701..748	CDD:275380	10/46 (22%)
		leucine-rich repeat	725..736	CDD:275378	3/10 (30%)
		leucine-rich repeat	749..772	CDD:275380	3/22 (14%)
		LRR_8	771..831	CDD:290566	15/59 (25%)
		leucine-rich repeat	773..793	CDD:275380	5/19 (26%)
		LRR_RI	804..1076	CDD:238064	73/274 (27%)
		LRR_8	821..903	CDD:290566	23/82 (28%)
		leucine-rich repeat	821..844	CDD:275380	6/22 (27%)
		leucine-rich repeat	845..868	CDD:275380	8/22 (36%)
		leucine-rich repeat	869..892	CDD:275380	3/22 (14%)
		leucine-rich repeat	893..915	CDD:275380	4/22 (18%)
		leucine-rich repeat	916..944	CDD:275380	7/27 (26%)
		leucine-rich repeat	945..968	CDD:275380	7/23 (30%)
		LRR_8	967..1027	CDD:290566	17/59 (29%)
		leucine-rich repeat	969..992	CDD:275380	6/22 (27%)
		leucine-rich repeat	993..1014	CDD:275380	5/20 (25%)
		LRR_8	1015..1075	CDD:290566	17/60 (28%)
		leucine-rich repeat	1017..1040	CDD:275380	7/22 (32%)
		leucine-rich repeat	1041..1064	CDD:275380	5/22 (23%)
		LRR_RI	<1047..1244	CDD:238064	25/85 (29%)
		LRR_8	1063..1125	CDD:290566	20/65 (31%)
		leucine-rich repeat	1089..1114	CDD:275380	7/26 (27%)
		leucine-rich repeat	1115..1162	CDD:275380	6/14 (43%)
		LRR_8	1163..1219	CDD:290566
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
AT4G36180	NP_195341.2	PLN00113	5..1115	CDD:215061	210/839 (25%)
		LRRNT_2	25..66	CDD:285463	6/25 (24%)
		leucine-rich repeat	70..93	CDD:275380	8/38 (21%)
		LRR_8	94..152	CDD:290566	15/61 (25%)
		leucine-rich repeat	94..117	CDD:275380	7/26 (27%)
		leucine-rich repeat	118..141	CDD:275380	6/22 (27%)
		leucine-rich repeat	142..163	CDD:275380	7/38 (18%)
		leucine-rich repeat	164..187	CDD:275380	9/22 (41%)
		leucine-rich repeat	188..211	CDD:275380	6/22 (27%)
		LRR_RI	209..491	CDD:238064	85/363 (23%)
		leucine-rich repeat	212..235	CDD:275380	5/22 (23%)
		leucine-rich repeat	236..259	CDD:275380	8/25 (32%)
		leucine-rich repeat	260..309	CDD:275380	17/71 (24%)
		leucine-rich repeat	310..333	CDD:275380	9/46 (20%)
		leucine-rich repeat	334..357	CDD:275380	5/22 (23%)
		leucine-rich repeat	358..405	CDD:275380	10/46 (22%)
		leucine-rich repeat	406..429	CDD:275380	3/22 (14%)
		LRR_RI	427..683	CDD:238064	80/309 (26%)
		leucine-rich repeat	430..453	CDD:275380	9/46 (20%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		leucine-rich repeat	478..501	CDD:275380	12/46 (26%)
		leucine-rich repeat	502..525	CDD:275380	4/22 (18%)
		leucine-rich repeat	526..549	CDD:275380	7/27 (26%)
		leucine-rich repeat	550..597	CDD:275380	13/47 (28%)
		leucine-rich repeat	598..621	CDD:275380	6/22 (27%)
		leucine-rich repeat	622..669	CDD:275380	12/46 (26%)
		leucine-rich repeat	670..689	CDD:275380	8/18 (44%)
		leucine-rich repeat	695..715	CDD:275380	6/19 (32%)
		PKc_like	847..1116	CDD:304357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I1746
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050