DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42346 and LRRC8E

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_001255213.1	Gene:	LRRC8E / 80131	HGNCID:	26272	Length:	796	Species:	Homo sapiens

Alignment Length:	436	Identity:	108/436 - (24%)
Similarity:	183/436 - (41%)	Gaps:	68/436 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 IHSLSIYDFDRSVTSLSQDVFQPGV---HIRHLQFSHSHL-EALKDNSLRNVRSSLE-SLSIVNG 335
            :|.:..||   |:.|....||...|   .::.|..:|... |.|:....||....|| :|.::.|
Human   367 LHLIDQYD---SLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCMLPG 428

  Fly   336 ------KLTQMPSRALSSMQKLTALDFDYNEIVRVDDYSF--------YGLRI------SKLNMK 380
                  :|:::.|..|.::..:| .....:::|.:.:.|.        :.|::      ..:.:|
Human   429 LPDTVFELSEVESLRLEAICDIT-FPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHLKVMRVK 492

  Fly   381 GNRLQGMPEHAFA--GLEECMQEIDVSENGLRTFPLMALRKLDHLRILRLSNN--RIPTFYGDIQ 441
            ...|:.:|...|.  ||||...|....:...|...|.:||:|..|::|.|.:|  ::|....|:.
Human   493 CEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVA 557

  Fly   442 ---------------LATNNASAAAA-------AVGAFQLPSLIF-------LDLSSNQFAEIGP 477
                           :|.|:....||       |.|..::|..:|       |||..|....|..
Human   558 GHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEE 622

  Fly   478 D-CFRAFPQLKTLSFYANQIELVQPEAFKSLRELMSLDMSHNRIIGLDPKVFEKNKRLQTVDLSH 541
            . .|:...:|.||..:.|||..| ||..:.||.|..|.:|:|::..| |........|:.:|:||
Human   623 ILSFQHCRKLVTLRLWHNQIAYV-PEHVRKLRSLEQLYLSYNKLETL-PSQLGLCSGLRLLDVSH 685

  Fly   542 NHIHTIGGVFSNLPQLREVFLSENNILELPADAFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLD 606
            |.:|::......|..|:.:.||.|.:..||.:.|. ...:..:.|..|.::.:.|:| ..|..|.
Human   686 NGLHSLPPEVGLLQNLQHLALSYNALEALPEELFF-CRKLRTLLLGDNQLSQLSPHV-GALRALS 748

  Fly   607 HLYLRSNFIPLLPVTLFD-KSTKLTSLSLDNNEIQDLEIGMFRKLE 651
            .|.|:.|.:..||..|.: ...|...|.:::...|.|...:..|:|
Human   749 RLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPAEVRDKME 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380	6/22 (27%)
		LRR_8	325..384	CDD:290566	12/79 (15%)
		leucine-rich repeat	327..350	CDD:275380	7/29 (24%)
		leucine-rich repeat	351..461	CDD:275380	30/149 (20%)
		LRR_8	373..433	CDD:290566	18/69 (26%)
		LRR_RI	397..648	CDD:238064	74/283 (26%)
		leucine-rich repeat	399..422	CDD:275380	6/22 (27%)
		leucine-rich repeat	462..485	CDD:275380	7/30 (23%)
		LRR_8	465..520	CDD:290566	21/55 (38%)
		leucine-rich repeat	486..509	CDD:275380	10/22 (45%)
		LRR_8	508..567	CDD:290566	18/58 (31%)
		leucine-rich repeat	510..533	CDD:275380	6/22 (27%)
		LRR_RI	527..785	CDD:238064	32/126 (25%)
		leucine-rich repeat	534..556	CDD:275380	7/21 (33%)
		LRR_8	555..613	CDD:290566	15/57 (26%)
		leucine-rich repeat	557..580	CDD:275380	7/22 (32%)
		leucine-rich repeat	581..604	CDD:275380	5/22 (23%)
		LRR_8	604..663	CDD:290566	13/49 (27%)
		leucine-rich repeat	605..628	CDD:275380	7/23 (30%)
		leucine-rich repeat	629..652	CDD:275380	5/23 (22%)
		LRR_8	652..711	CDD:290566	108/436 (25%)
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		LRR_8	771..831	CDD:290566
		leucine-rich repeat	773..793	CDD:275380
		LRR_RI	804..1076	CDD:238064
		LRR_8	821..903	CDD:290566
		leucine-rich repeat	821..844	CDD:275380
		leucine-rich repeat	845..868	CDD:275380
		leucine-rich repeat	869..892	CDD:275380
		leucine-rich repeat	893..915	CDD:275380
		leucine-rich repeat	916..944	CDD:275380
		leucine-rich repeat	945..968	CDD:275380
		LRR_8	967..1027	CDD:290566
		leucine-rich repeat	969..992	CDD:275380
		leucine-rich repeat	993..1014	CDD:275380
		LRR_8	1015..1075	CDD:290566
		leucine-rich repeat	1017..1040	CDD:275380
		leucine-rich repeat	1041..1064	CDD:275380
		LRR_RI	<1047..1244	CDD:238064
		LRR_8	1063..1125	CDD:290566
		leucine-rich repeat	1089..1114	CDD:275380
		leucine-rich repeat	1115..1162	CDD:275380
		LRR_8	1163..1219	CDD:290566
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
LRRC8E	NP_001255213.1	Pannexin_like	1..331	CDD:289311
		leucine-rich repeat	486..508	CDD:275380	4/21 (19%)
		LRR 1	508..529		6/20 (30%)
		leucine-rich repeat	509..527	CDD:275380	5/17 (29%)
		LRR_RI	520..760	CDD:238064	65/243 (27%)
		LRR 2	536..557		6/20 (30%)
		leucine-rich repeat	537..559	CDD:275380	6/21 (29%)
		LRR 3	559..579		2/19 (11%)
		leucine-rich repeat	560..583	CDD:275380	2/22 (9%)
		LRR 4	583..604		5/20 (25%)
		LRR_8	584..642	CDD:290566	14/57 (25%)
		leucine-rich repeat	584..606	CDD:275380	4/21 (19%)
		LRR 5	606..627		5/20 (25%)
		leucine-rich repeat	607..631	CDD:275380	6/23 (26%)
		LRR_8	630..688	CDD:290566	22/59 (37%)
		LRR 6	631..652		9/21 (43%)
		leucine-rich repeat	632..654	CDD:275380	10/22 (45%)
		LRR 7	654..675		6/21 (29%)
		leucine-rich repeat	655..677	CDD:275380	6/22 (27%)
		LRR_8	676..734	CDD:290566	16/58 (28%)
		LRR 8	677..698		6/20 (30%)
		leucine-rich repeat	678..700	CDD:275380	7/21 (33%)
		LRR 9	700..721		7/21 (33%)
		leucine-rich repeat	701..723	CDD:275380	7/22 (32%)
		LRR 10	723..744		4/21 (19%)
		leucine-rich repeat	724..746	CDD:275380	5/22 (23%)
		LRR 11	746..767		7/20 (35%)
		leucine-rich repeat	747..767	CDD:275380	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000