DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and Lrrc8e

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_082451.2 Gene:Lrrc8e / 72267 MGIID:1919517 Length:795 Species:Mus musculus


Alignment Length:447 Identity:119/447 - (26%)
Similarity:188/447 - (42%) Gaps:90/447 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   276 IHSLSIYDFDRSVTSLSQDVFQPGV---HIRHLQFSHSHL-EALKDNSLRNVRSSLE-SLSIVNG 335
            :|.:..||   |:.|....||...|   .::.|..:|... |.|:....||:|..|| ||.::.|
Mouse   366 LHLIDQYD---SLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNMRGRLELSLCMLPG 427

  Fly   336 KLTQMPSRA--LSSMQ--KLTAL-DFDY----NEIVRVDDYS--------------FYGLRISKL 377
                :|...  ||.::  :|.|: |..:    :::|.:.:.|              |...|:..:
Mouse   428 ----LPDTVFELSEVEALRLEAICDISFPPGLSQLVNLQELSLLHSPARLPFSSQIFLRDRLKVI 488

  Fly   378 NMKGNRLQGMPEHAFA--GLEECMQEIDVSENGLRTFP--------LMALRKLDHLRILRLSNN- 431
            .:|...|:.:|...|.  ||||...|      ||  ||        |.:||:|..|::|.|.:| 
Mouse   489 CVKFEELREVPLWVFGLRGLEELHLE------GL--FPPEMARGATLESLRELKQLKVLSLRSNA 545

  Fly   432 -RIPTFYGDIQ---------------LATNNASAAA-------AAVGAFQLPSLIF-------LD 466
             ::|....|:.               ||.|:....|       .|.|..::|..||       ||
Mouse   546 GKVPASVTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLERIPHAIFSLGALQELD 610

  Fly   467 LSSNQFAEIGPD-CFRAFPQLKTLSFYANQIELVQPEAFKSLRELMSLDMSHNRIIGLDPKVFEK 530
            |..|....|... .|:...:|.||..:.|||..| ||..:.||.|..|.:|||::..| |....:
Mouse   611 LKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYV-PEHVRKLRSLEQLYLSHNKLETL-PTQLGQ 673

  Fly   531 NKRLQTVDLSHNHIHTIGGVFSNLPQLREVFLSENNILELPADAFTNSTNVDVIYLESNAIAHID 595
            ...|:.:|||||.:.::......|..|:.:.||.|.:..||.:.|. ...:..:.|..|.:..:.
Mouse   674 CFGLRLLDLSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELFF-CHKLRTLLLGYNHLTQLS 737

  Fly   596 PNVFSTLVNLDHLYLRSNFIPLLPVTLFD-KSTKLTSLSLDNNEIQDLEIGMFRKLE 651
            |:| :.|..|..|.|:.|.:..||..|.| |..|.:.|.:::...:.|...:..|:|
Mouse   738 PDV-AALQALSRLELKGNRLETLPEELGDCKGLKKSGLLVEDTLYEGLPAEVREKME 793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380 6/22 (27%)
LRR_8 325..384 CDD:290566 16/82 (20%)
leucine-rich repeat 327..350 CDD:275380 8/27 (30%)
leucine-rich repeat 351..461 CDD:275380 36/162 (22%)
LRR_8 373..433 CDD:290566 22/71 (31%)
LRR_RI 397..648 CDD:238064 80/291 (27%)
leucine-rich repeat 399..422 CDD:275380 9/30 (30%)
leucine-rich repeat 462..485 CDD:275380 8/30 (27%)
LRR_8 465..520 CDD:290566 22/55 (40%)
leucine-rich repeat 486..509 CDD:275380 10/22 (45%)
LRR_8 508..567 CDD:290566 19/58 (33%)
leucine-rich repeat 510..533 CDD:275380 7/22 (32%)
LRR_RI 527..785 CDD:238064 33/126 (26%)
leucine-rich repeat 534..556 CDD:275380 7/21 (33%)
LRR_8 555..613 CDD:290566 15/57 (26%)
leucine-rich repeat 557..580 CDD:275380 7/22 (32%)
leucine-rich repeat 581..604 CDD:275380 5/22 (23%)
LRR_8 604..663 CDD:290566 14/49 (29%)
leucine-rich repeat 605..628 CDD:275380 9/23 (39%)
leucine-rich repeat 629..652 CDD:275380 4/23 (17%)
LRR_8 652..711 CDD:290566 119/447 (27%)
leucine-rich repeat 653..676 CDD:275380
leucine-rich repeat 677..700 CDD:275380
leucine-rich repeat 701..748 CDD:275380
leucine-rich repeat 725..736 CDD:275378
leucine-rich repeat 749..772 CDD:275380
LRR_8 771..831 CDD:290566
leucine-rich repeat 773..793 CDD:275380
LRR_RI 804..1076 CDD:238064
LRR_8 821..903 CDD:290566
leucine-rich repeat 821..844 CDD:275380
leucine-rich repeat 845..868 CDD:275380
leucine-rich repeat 869..892 CDD:275380
leucine-rich repeat 893..915 CDD:275380
leucine-rich repeat 916..944 CDD:275380
leucine-rich repeat 945..968 CDD:275380
LRR_8 967..1027 CDD:290566
leucine-rich repeat 969..992 CDD:275380
leucine-rich repeat 993..1014 CDD:275380
LRR_8 1015..1075 CDD:290566
leucine-rich repeat 1017..1040 CDD:275380
leucine-rich repeat 1041..1064 CDD:275380
LRR_RI <1047..1244 CDD:238064
LRR_8 1063..1125 CDD:290566
leucine-rich repeat 1089..1114 CDD:275380
leucine-rich repeat 1115..1162 CDD:275380
LRR_8 1163..1219 CDD:290566
leucine-rich repeat 1163..1186 CDD:275380
leucine-rich repeat 1187..1210 CDD:275380
leucine-rich repeat 1211..1233 CDD:275380
leucine-rich repeat 1234..1257 CDD:275380
LRR_8 1235..1292 CDD:290566
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
Lrrc8eNP_082451.2 Pannexin_like 1..330 CDD:372171
PLN00113 412..>756 CDD:215061 97/359 (27%)
LRR 1 535..556 6/20 (30%)
leucine-rich repeat 536..558 CDD:275380 6/21 (29%)
LRR 2 558..578 3/19 (16%)
leucine-rich repeat 559..582 CDD:275380 3/22 (14%)
LRR 3 582..603 5/20 (25%)
leucine-rich repeat 583..605 CDD:275380 5/21 (24%)
LRR 4 605..626 5/20 (25%)
LRR <606..>771 CDD:227223 52/168 (31%)
leucine-rich repeat 606..630 CDD:275380 6/23 (26%)
LRR 5 630..651 9/21 (43%)
leucine-rich repeat 631..653 CDD:275380 10/22 (45%)
LRR 6 653..674 7/21 (33%)
leucine-rich repeat 654..676 CDD:275380 7/22 (32%)
LRR 7 676..697 6/20 (30%)
leucine-rich repeat 677..699 CDD:275380 7/21 (33%)
LRR 8 699..720 7/21 (33%)
leucine-rich repeat 700..722 CDD:275380 7/22 (32%)
LRR 9 722..744 4/22 (18%)
leucine-rich repeat 723..745 CDD:275380 5/22 (23%)
LRR 10 745..766 7/20 (35%)
leucine-rich repeat 746..766 CDD:275380 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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