DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and TLR5

DIOPT Version :10

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_003259.2 Gene:TLR5 / 7100 HGNCID:11851 Length:858 Species:Homo sapiens


Alignment Length:891 Identity:216/891 - (24%)
Similarity:341/891 - (38%) Gaps:230/891 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   386 GMPEHAFAG---------LEECMQEIDVSE------NGLRTFPLMALRKLDHLRILRLSNNRIPT 435
            |:|..:|.|         |.:..|.::.:|      |.:||....:...|:.|::|.|.:...| 
Human    20 GIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTP- 83

  Fly   436 FYGDIQLATNNASAAAAAVGAFQ-LPSLIFLDLSSNQFAEIGPDCFRAFPQLKTLSFYANQIE-- 497
                  |..:..        ||: ||:|..|||.|::...:.||.|:....|..|..|...:.  
Human    84 ------LTIDKE--------AFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDA 134

  Fly   498 LVQPEAFKSLRELMSLDMSHNRI--IGLDPKVFEKNKRLQTVDLSHNHIHTIGGVFSNLPQLREV 560
            :::...|::|:.|..||:|.|:|  :.|.|. |.|...|:::|.|.|.|..:  ....|..|:..
Human   135 VLKDGYFRNLKALTRLDLSKNQIRSLYLHPS-FGKLNSLKSIDFSSNQIFLV--CEHELEPLQGK 196

  Fly   561 FLS------------------------ENNILELPADAFTNSTNVDVIYLESNAIA--------- 592
            .||                        .|.:||: .|...|...||:....||||:         
Human   197 TLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEI-LDVSGNGWTVDITGNFSNAISKSQAFSLIL 260

  Fly   593 --HI-------------DPNVFSTLV--NLDHLYLRSNFIPLLPVTLFDKSTKLTSLSLDNNEIQ 640
              ||             |.|.|:.|.  ::.||.|...|:..|...:|:....|..|:|..|:|.
Human   261 AHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN 325

  Fly   641 DLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQELHIQKNSIEDIEPQAFHTLENMQHIN 705
            .:....|..|::|:.:.|..|.:..:....|..||.:..:.:|||.|..|:.|.|..||.:|.::
Human   326 KIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLD 390

  Fly   706 LQDNQLTVLE------DIFPDENS--SLLSVQLEANYLHKVHPRTFSRQQKVQIMWLKDNQLTRV 762
            |:||.||.:.      |||...|.  :|..:.|.||.:|                 |.:|:|..:
Human   391 LRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIH-----------------LSENRLENL 438

  Fly   763 ERSFF-ADTPQLGRLYLSDNKIRDIEKDTFVNLLLLQFLDLSGNQLRQLRRDYFAPLQD--LEEL 824
            :..:| ...|.|..|.|:.|:                |...||:|         .|.::  ||:|
Human   439 DILYFLLRVPHLQILILNQNR----------------FSSCSGDQ---------TPSENPSLEQL 478

  Fly   825 SLARNHI----------EAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLNLGNCSL 879
            .|..|.:          :..||     |.:|:.|.|:||.|..|...:||:...|..|:|.:..|
Human   479 FLGENMLQLAWETELCWDVFEG-----LSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL 538

  Fly   880 RKLEQHAFKSLTNLNELNLERNQL---NP---ADIQTLDIPNLRRLL----------LSHNNFSY 928
            ..|..:...:  ||..|::.||||   ||   ..:..|||.:.:.:.          |:|.|.:.
Human   539 TVLSHNDLPA--NLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTI 601

  Fly   929 AG-SVGIMAGMLDRLR--SLQQLSMSNCS----LGQIPDLLFAKNTNLVRLDLCDNRLTQINRNI 986
            || ...|.....|...  ||..||...|.    |..:...||...|..:.|.|    :|.:....
Human   602 AGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFL----MTILTVTK 662

  Fly   987 FSGL----------NVFK-------------ELRLCRNELSDFPHIALYNLSTLESLDLARNQLA 1028
            |.|.          .|||             :..||.:. .||..:   ..:.|:.||   .|.:
Human   663 FRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSS-KDFTWV---QNALLKHLD---TQYS 720

  Fly  1029 SIDFFKLSGTLNLRQLILRDNKITALSGFNAVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVH 1093
            ..:.|.|  ....|..:..:|:|..:.          |::..|..::..:..:|||....|:...
Human   721 DQNRFNL--CFEERDFVPGENRIANIQ----------DAIWNSRKIVCLVSRHFLRDGWCLEAFS 773

  Fly  1094 LSNNRFLQIPSSALSDVSIPRLSWLNLTGNPINRIYTVKEE--RYP 1137
            .:..|.|...:|||..|.:..||...|..:...|.:..|::  |:|
Human   774 YAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWP 819

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 LRR <301..606 CDD:443914 69/289 (24%)
leucine-rich repeat 303..325 CDD:275380
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380 19/90 (21%)
leucine-rich repeat 399..422 CDD:275380 6/28 (21%)
leucine-rich repeat 462..485 CDD:275380 8/22 (36%)
LRR 486..>736 CDD:443914 83/311 (27%)
leucine-rich repeat 486..509 CDD:275380 5/24 (21%)
leucine-rich repeat 510..533 CDD:275380 10/24 (42%)
leucine-rich repeat 534..556 CDD:275380 6/21 (29%)
leucine-rich repeat 557..580 CDD:275380 8/46 (17%)
leucine-rich repeat 581..604 CDD:275380 12/48 (25%)
leucine-rich repeat 605..628 CDD:275380 6/22 (27%)
PPP1R42 627..860 CDD:455733 66/253 (26%)
leucine-rich repeat 629..652 CDD:275380 7/22 (32%)
leucine-rich repeat 653..676 CDD:275380 5/22 (23%)
leucine-rich repeat 677..700 CDD:275380 8/22 (36%)
leucine-rich repeat 701..748 CDD:275380 15/54 (28%)
leucine-rich repeat 725..736 CDD:275378 4/10 (40%)
leucine-rich repeat 749..772 CDD:275380 4/23 (17%)
leucine-rich repeat 773..793 CDD:275380 4/19 (21%)
leucine-rich repeat 821..844 CDD:275380 8/32 (25%)
leucine-rich repeat 845..868 CDD:275380 9/22 (41%)
LRR 869..1226 CDD:443914 73/317 (23%)
leucine-rich repeat 869..892 CDD:275380 5/22 (23%)
leucine-rich repeat 893..915 CDD:275380 11/27 (41%)
leucine-rich repeat 916..944 CDD:275380 7/40 (18%)
leucine-rich repeat 945..968 CDD:275380 7/26 (27%)
leucine-rich repeat 969..992 CDD:275380 5/32 (16%)
leucine-rich repeat 993..1014 CDD:275380 6/33 (18%)
leucine-rich repeat 1017..1040 CDD:275380 6/22 (27%)
leucine-rich repeat 1041..1064 CDD:275380 3/22 (14%)
leucine-rich repeat 1089..1114 CDD:275380 7/24 (29%)
leucine-rich repeat 1115..1162 CDD:275380 7/25 (28%)
PPP1R42 1155..1317 CDD:455733
leucine-rich repeat 1163..1186 CDD:275380
leucine-rich repeat 1187..1210 CDD:275380
leucine-rich repeat 1211..1233 CDD:275380
leucine-rich repeat 1234..1257 CDD:275380
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
TLR5NP_003259.2 LRR 1. /evidence=ECO:0000269|PubMed:22173220 45..68 4/22 (18%)
leucine-rich repeat 48..83 CDD:275378 8/34 (24%)
LRR 2. /evidence=ECO:0000269|PubMed:22173220 71..93 7/36 (19%)
LRR_8 95..182 CDD:404697 28/87 (32%)
LRR 3. /evidence=ECO:0000269|PubMed:22173220 95..117 9/21 (43%)
leucine-rich repeat 97..120 CDD:275380 8/22 (36%)
LRR 4. /evidence=ECO:0000269|PubMed:22173220 120..143 4/22 (18%)
leucine-rich repeat 121..146 CDD:275380 5/24 (21%)
LRR 5. /evidence=ECO:0000269|PubMed:22173220 146..166 8/20 (40%)
leucine-rich repeat 147..171 CDD:275380 10/24 (42%)
LRR 6. /evidence=ECO:0000269|PubMed:22173220 171..192 6/22 (27%)
leucine-rich repeat 172..205 CDD:275380 9/34 (26%)
LRR 7. /evidence=ECO:0000269|PubMed:22173220 197..211 2/13 (15%)
LRR 8. /evidence=ECO:0000269|PubMed:22173220 214..229 1/14 (7%)