DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and TLR2

DIOPT Version :10

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_003255.2 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens


Alignment Length:662 Identity:149/662 - (22%)
Similarity:252/662 - (38%) Gaps:184/662 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   549 GVFSNLPQ-----LREVFLSENNILELPADAFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHL 608
            |..:::|.     ::.:.||.|.|..:.........|:..:.|.||.|..|:.:.||:|.:|:||
Human    41 GSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHL 105

  Fly   609 YLRSNFIPLLPVTLFDKSTKLTSLSLDNNEIQDL-EIGMFRKLEHLREVRLHN-NRIRRVRRGVF 671
            .|..|::..|..:.|...:.||.|:|..|..:.| |..:|..|..|:.:|:.| :...:::|..|
Human   106 DLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDF 170

  Fly   672 EPLPSLQELHIQKNSIEDIEPQAFHTLENMQHINLQDNQLTVLEDIFPDENSSLLSVQLEANYLH 736
            ..|..|:||.|..:.::..||::..:::|:.|:.|...|..:|.:||.|..||:..::|      
Human   171 AGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLEL------ 229

  Fly   737 KVHPRTFSRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYLSDNKIRDIEKDTFVNLLLLQFLD 801
                                                           ||.:.|||      .|.:
Human   230 -----------------------------------------------RDTDLDTF------HFSE 241

  Fly   802 LSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNE 866
            ||..:...|                       |:.:.|   :|:|..|.|...:::|...|..  
Human   242 LSTGETNSL-----------------------IKKFTF---RNVKITDESLFQVMKLLNQISG-- 278

  Fly   867 FPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLDIPNLRRLLLSHNNFSYAGS 931
              |..|...:|:|..:..  |::..|       ...::|..::||.|   |||            
Human   279 --LLELEFDDCTLNGVGN--FRASDN-------DRVIDPGKVETLTI---RRL------------ 317

  Fly   932 VGIMAGMLDRLRSLQQLSMSNCSLGQIPDL-LFAKNTNLVRLDLCDNRLTQINRNIFSGLNVFKE 995
                                     .||.. ||...:.|..|.....|:|..|..:|.       
Human   318 -------------------------HIPRFYLFYDLSTLYSLTERVKRITVENSKVFL------- 350

  Fly   996 LRLCRNELSDFPHIALYNLSTLESLDLARNQLASIDFFKLSGT----LNLRQLILRDNKITAL-- 1054
                      .|.:...:|.:||.|||:.|.:.. ::.|.|..    .:|:.||||.|.:.:|  
Human   351 ----------VPCLLSQHLKSLEYLDLSENLMVE-EYLKNSACEDAWPSLQTLILRQNHLASLEK 404

  Fly  1055 SGFNAVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVHLSNNRFLQIPSSALSDVSIPR-LSWL 1118
            :|...:.|..|.::|:|.|...|:|.. .:....::.::||:.|...:..      .||: |..|
Human   405 TGETLLTLKNLTNIDISKNSFHSMPET-CQWPEKMKYLNLSSTRIHSVTG------CIPKTLEIL 462

  Fly  1119 NLTGNPINRIYTVKEERYPYLKELYICQTNLSILTSKDFEAFQALQHLHLVNNRITRISPGAFKS 1183
            :::.|.:| ::::   ..|.||||||.:..|  :|..|......|..|.:..|.||..|.....|
Human   463 DVSNNNLN-LFSL---NLPQLKELYISRNKL--MTLPDASLLPMLLVLKISRNAITTFSKEQLDS 521

  Fly  1184 LTNLLTLDLSVN 1195
            ...|.||:...|
Human   522 FHTLKTLEAGGN 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 LRR <301..606 CDD:443914 15/61 (25%)
leucine-rich repeat 303..325 CDD:275380
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380
leucine-rich repeat 399..422 CDD:275380
leucine-rich repeat 462..485 CDD:275380
LRR 486..>736 CDD:443914 54/193 (28%)
leucine-rich repeat 486..509 CDD:275380
leucine-rich repeat 510..533 CDD:275380
leucine-rich repeat 534..556 CDD:275380 1/6 (17%)
leucine-rich repeat 557..580 CDD:275380 4/22 (18%)
leucine-rich repeat 581..604 CDD:275380 8/22 (36%)
leucine-rich repeat 605..628 CDD:275380 7/22 (32%)
PPP1R42 627..860 CDD:455733 48/234 (21%)
leucine-rich repeat 629..652 CDD:275380 9/23 (39%)
leucine-rich repeat 653..676 CDD:275380 6/23 (26%)
leucine-rich repeat 677..700 CDD:275380 6/22 (27%)
leucine-rich repeat 701..748 CDD:275380 10/46 (22%)
leucine-rich repeat 725..736 CDD:275378 1/10 (10%)
leucine-rich repeat 749..772 CDD:275380 0/22 (0%)
leucine-rich repeat 773..793 CDD:275380 5/19 (26%)
leucine-rich repeat 821..844 CDD:275380 2/22 (9%)
leucine-rich repeat 845..868 CDD:275380 5/22 (23%)
LRR 869..1226 CDD:443914 78/335 (23%)
leucine-rich repeat 869..892 CDD:275380 5/22 (23%)
leucine-rich repeat 893..915 CDD:275380 4/21 (19%)
leucine-rich repeat 916..944 CDD:275380 3/27 (11%)
leucine-rich repeat 945..968 CDD:275380 4/23 (17%)
leucine-rich repeat 969..992 CDD:275380 6/22 (27%)
leucine-rich repeat 993..1014 CDD:275380 1/20 (5%)
leucine-rich repeat 1017..1040 CDD:275380 8/26 (31%)
leucine-rich repeat 1041..1064 CDD:275380 9/24 (38%)
leucine-rich repeat 1089..1114 CDD:275380 4/24 (17%)
leucine-rich repeat 1115..1162 CDD:275380 14/46 (30%)
PPP1R42 1155..1317 CDD:455733 12/41 (29%)
leucine-rich repeat 1163..1186 CDD:275380 7/22 (32%)
leucine-rich repeat 1187..1210 CDD:275380 4/9 (44%)
leucine-rich repeat 1211..1233 CDD:275380
leucine-rich repeat 1234..1257 CDD:275380
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
TLR2NP_003255.2 LRR <39..296 CDD:443914 75/345 (22%)
leucine-rich repeat 54..77 CDD:275378 4/22 (18%)
LRR 1 54..77 4/22 (18%)
leucine-rich repeat 78..101 CDD:275378 8/22 (36%)
LRR 2 78..101 8/22 (36%)
leucine-rich repeat 102..125 CDD:275378 7/22 (32%)
LRR 3 102..125 7/22 (32%)
leucine-rich repeat 126..150 CDD:275378 9/23 (39%)
LRR 4 126..150 9/23 (39%)
LRR 5 151..175 6/23 (26%)
LRR 6 176..199 6/22 (27%)
leucine-rich repeat 176..196 CDD:275380 6/19 (32%)
LRR 7 200..223 7/22 (32%)
LRR 221..>556 CDD:443914 98/482 (20%)
LRR 8 224..250 9/84 (11%)
LRR 9 251..278 8/29 (28%)
LRR 10 279..308 7/37 (19%)
LRR 11 309..337 12/67 (18%)
LRR 12 338..361 6/39 (15%)
leucine-rich repeat 362..388 CDD:275380 8/26 (31%)
LRR 13 362..388 8/26 (31%)
leucine-rich repeat 389..414 CDD:275380 9/24 (38%)
LRR 14 389..414 9/24 (38%)
leucine-rich repeat 415..437 CDD:275380 6/22 (27%)
LRR 15 415..437 6/22 (27%)
leucine-rich repeat 438..478 CDD:275380 9/49 (18%)
LRR 16 438..457 4/24 (17%)
LRR 17 458..478 4/23 (17%)
leucine-rich repeat 479..500 CDD:275380 9/22 (41%)
LRR 18 479..500 9/22 (41%)
leucine-rich repeat 501..524 CDD:275380 7/22 (32%)
LRR 19 501..524 7/22 (32%)
LRRCT 533..586 CDD:214507 1/1 (100%)
TIR 640..784 CDD:214587
ATG16L1-binding motif 761..778
Blue background indicates that the domain is not in the aligned region.

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