DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and si:dkey-1j5.4

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	XP_009293145.1	Gene:	si:dkey-1j5.4 / 563949	ZFINID:	ZDB-GENE-130603-91	Length:	357	Species:	Danio rerio

Alignment Length:	338	Identity:	81/338 - (23%)
Similarity:	137/338 - (40%)	Gaps:	90/338 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 LESLSIVNGK--LTQMPSRALSSMQKLTALDFDYNEIVRVDDYSFYGL-RISKLNMKGNRLQGMP 388
            |:|..:..|:  |..:|...|||:.|:.::..:.|.|..:...:|.|. |:..||::|||:..:|
Zfish    54 LDSWILKMGENFLQDLPGSLLSSVPKIESVKLERNSIKSIHPQAFAGAQRLMLLNLQGNRISKIP 118

  Fly   389 EHAFAGLEECMQEIDVSENGLRTFPLMALRKLDHLRILRLSNNRIPTFYGDIQLATNNASAAAAA 453
            ...|                         :.|.:||.|.|..|:|.....::.:...|.|.
Zfish   119 VKGF-------------------------KDLLNLRFLMLGQNQIANLKPNMFIGMRNLSE---- 154

  Fly   454 VGAFQLPSLIFLDLSSNQFAEIGPDCFRAFPQLKTLSFYANQIELVQPEAFKSLRELMSLDMSHN 518
                       |||..|....:.|:.|:....||.|....|:|:.:.|:||..|.||:.|:|.:|
Zfish   155 -----------LDLPLNALTALPPNAFKPLIALKVLDLSLNRIQRISPKAFVGLEELLFLNMDNN 208

  Fly   519 RIIGLDPKVFEKNKRLQTVDLSHNHIHTIGGVFSNLPQLREVFLSENNILELPADAFTNSTNVDV 583
            ::           |.:|            .|.|..|                        |.:::
Zfish   209 KL-----------KSIQ------------AGTFGPL------------------------TGLEM 226

  Fly   584 IYLESNAIAHIDPNVFSTLVNLDHLYLRSNFIPLLPVTLFDKSTKLTSLSLDNNEIQDLEIGMFR 648
            :.|::|.::.:..:....|.||..||:|.|.|..||..:|..:.|||.:.|..|.:..::..|..
Zfish   227 LVLDNNLLSTLTVSTLEGLSNLQELYVRKNEIESLPADVFLHTPKLTHVGLSGNRLHAIDGNMLA 291

  Fly   649 KLEHLREVRLHNN 661
            .::.|:||.||:|
Zfish   292 NMQGLKEVFLHDN 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566	18/59 (31%)
		leucine-rich repeat	327..350	CDD:275380	8/24 (33%)
		leucine-rich repeat	351..461	CDD:275380	21/110 (19%)
		LRR_8	373..433	CDD:290566	14/59 (24%)
		LRR_RI	397..648	CDD:238064	54/250 (22%)
		leucine-rich repeat	399..422	CDD:275380	1/22 (5%)
		leucine-rich repeat	462..485	CDD:275380	6/22 (27%)
		LRR_8	465..520	CDD:290566	20/54 (37%)
		leucine-rich repeat	486..509	CDD:275380	9/22 (41%)
		LRR_8	508..567	CDD:290566	10/58 (17%)
		leucine-rich repeat	510..533	CDD:275380	4/22 (18%)
		LRR_RI	527..785	CDD:238064	31/135 (23%)
		leucine-rich repeat	534..556	CDD:275380	4/21 (19%)
		LRR_8	555..613	CDD:290566	9/57 (16%)
		leucine-rich repeat	557..580	CDD:275380	0/22 (0%)
		leucine-rich repeat	581..604	CDD:275380	3/22 (14%)
		LRR_8	604..663	CDD:290566	22/58 (38%)
		leucine-rich repeat	605..628	CDD:275380	9/22 (41%)
		leucine-rich repeat	629..652	CDD:275380	5/22 (23%)
		LRR_8	652..711	CDD:290566	6/10 (60%)
		leucine-rich repeat	653..676	CDD:275380	6/9 (67%)
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		LRR_8	771..831	CDD:290566
		leucine-rich repeat	773..793	CDD:275380
		LRR_RI	804..1076	CDD:238064
		LRR_8	821..903	CDD:290566
		leucine-rich repeat	821..844	CDD:275380
		leucine-rich repeat	845..868	CDD:275380
		leucine-rich repeat	869..892	CDD:275380
		leucine-rich repeat	893..915	CDD:275380
		leucine-rich repeat	916..944	CDD:275380
		leucine-rich repeat	945..968	CDD:275380
		LRR_8	967..1027	CDD:290566
		leucine-rich repeat	969..992	CDD:275380
		leucine-rich repeat	993..1014	CDD:275380
		LRR_8	1015..1075	CDD:290566
		leucine-rich repeat	1017..1040	CDD:275380
		leucine-rich repeat	1041..1064	CDD:275380
		LRR_RI	<1047..1244	CDD:238064
		LRR_8	1063..1125	CDD:290566
		leucine-rich repeat	1089..1114	CDD:275380
		leucine-rich repeat	1115..1162	CDD:275380
		LRR_8	1163..1219	CDD:290566
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
si:dkey-1j5.4	XP_009293145.1	LRRNT	21..53	CDD:279764
		leucine-rich repeat	36..54	CDD:275380	81/338 (24%)
		LRR_8	58..114	CDD:290566	16/55 (29%)
		LRR_RI	59..282	CDD:238064	72/309 (23%)
		leucine-rich repeat	80..103	CDD:275380	4/22 (18%)
		LRR_8	103..162	CDD:290566	21/98 (21%)
		leucine-rich repeat	104..127	CDD:275380	8/47 (17%)
		leucine-rich repeat	128..151	CDD:275380	6/22 (27%)
		LRR_8	150..210	CDD:290566	22/74 (30%)
		leucine-rich repeat	152..175	CDD:275380	7/37 (19%)
		leucine-rich repeat	176..199	CDD:275380	9/22 (41%)
		leucine-rich repeat	200..223	CDD:275380	9/69 (13%)
		LRR_8	222..282	CDD:290566	19/59 (32%)
		leucine-rich repeat	224..247	CDD:275380	3/22 (14%)
		leucine-rich repeat	248..271	CDD:275380	9/22 (41%)
		leucine-rich repeat	272..293	CDD:275380	5/20 (25%)
		LRRCT	304..356	CDD:214507	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910