DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and lrrc8ab

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:XP_005165659.1 Gene:lrrc8ab / 557928 ZFINID:ZDB-GENE-060531-43 Length:796 Species:Danio rerio


Alignment Length:755 Identity:175/755 - (23%)
Similarity:289/755 - (38%) Gaps:202/755 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   253 LFLEC---PGTTAISLRSTLERISAPIHSLSIY-DFDRSVTSLSQDVFQPGVHIRHLQFSHSHLE 313
            :.|:|   |.||. :|..|:...|.|...:.:. .||:..:.:|:||   ...:..|..:.|.:|
Zfish   146 ILLKCFDSPWTTR-ALSETVVEESDPKCLVKMNGSFDKKASYVSEDV---EASVPMLSTTRSRIE 206

  Fly   314 -ALKDNSLRNVRSSLESLSIVNGKLTQMPSRALSSMQKLTALDFDYNEIVRVDDYSFYGLRISKL 377
             .:.|:|...|....|.          ..::||....|...:..:..:||       |.|.|.:.
Zfish   207 QGIVDHSETGVLDKKEG----------EQAKALFEKVKKFRIHVEEGDIV-------YRLYIRQT 254

  Fly   378 NMKGNRL------QGMPEHAFAGLEECMQEIDVSENGLRTF----PLMALRKL------------ 420
            .:|..:.      .|...|......:|..:|: |..|.|.:    ||..|.|:            
Zfish   255 IIKVVKFILIICYTGYYVHNIQFNVDCNVDIE-SLTGYRMYNCAHPLATLFKILACFYISLVIVY 318

  Fly   421 -------------DHLRILRLSNNRIPTFYGDIQLATNNASAAAAAVGAFQLPSLIFLD-LSSNQ 471
                         ..|:.....:.|..:.|.||....|:.        ||.|..:...| |.|.:
Zfish   319 GMICVYTLSWMLRRSLKKYSFESIREESSYSDIPDVKNDF--------AFMLHMIDQYDPLYSKR 375

  Fly   472 FA----EIGPDCFRAFPQLKTLSFYANQIELVQPEAFKSLRELMSLDMSHNRIIGLDPKVFEKNK 532
            ||    |:..:..|   ||...:.:.  :|.::....|:.:|.:.|.:.  .:.|:...||:. .
Zfish   376 FAVFLSEVSENKLR---QLNLNNEWT--LEKLRQRITKNSQEKLELHLF--MLSGIPDTVFDL-V 432

  Fly   533 RLQTVDLSHNHIHTIGGVFSNLPQLREVFLSENNI-LELPADAFTNSTNVDVIYLESNAIAHIDP 596
            .|:.:.|......||..:.:.|..|||::|..... :|.||.||... |:..::::...|..|..
Zfish   433 ELEVLKLELIPDVTIPPIIAQLTNLREMWLYHTPAKIEAPALAFLRE-NLKSLHIKFTDIKEIPL 496

  Fly   597 NVFSTLVNLDHLYLRSNFIPLLPVTLFDKSTKLTSLSLDNNEIQDLEIGMFRKLEHLREVRLHNN 661
            .::| |.||..|:|..|                  ||.|||..  :.|...|:|:.|:.:||.:|
Zfish   497 WIYS-LKNLSELHLTGN------------------LSADNNRY--IVIDGLRELKRLKVLRLKSN 540

  Fly   662 RIRRVRRGVFEPLPSLQE---LHIQKNSIE--------------------------DIE--PQAF 695
            ..:         ||.:..   :|:||.||.                          |:|  |.:.
Zfish   541 LTK---------LPQVVTDVGMHLQKLSINNEGTKLMVLNSLKKMVNLSELELVRCDLERIPHSI 596

  Fly   696 HTLENMQHINLQDNQLTVLEDIFPDENSSLLSVQLEANYLHKVHPRTFSRQQKVQI-MWLKDNQL 759
            .:|.|:|.|:|:||.|..:|:|        :|.|    :||::          |.: :|.  ||:
Zfish   597 FSLHNLQEIDLKDNNLKTIEEI--------ISFQ----HLHRL----------VCLKLWY--NQI 637

  Fly   760 TRVERSFFADTPQLGRLYLSDNKIRDIEKDTFVNLLLLQFLDLSGNQLRQLRRDYFAPLQDLEEL 824
            ..:... ......|.||||:.|||..:....|. ...::|||||.|.|..:..: ...||:|:.|
Zfish   638 AYIPIQ-IGTLVNLERLYLNRNKIEKMPHQLFF-CRKMRFLDLSHNNLTDIPSE-IGTLQNLQYL 699

  Fly   825 SLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLNLGNCSLRKLEQHAFKS 889
            ::..|.||::....|...|                         |.:|||||..|:.|... |..
Zfish   700 AVTANRIESLPPELFQCKK-------------------------LRTLNLGNNCLQSLPSR-FGE 738

  Fly   890 LTNLNELNLERNQLNPADIQTLDIPNLRR--LLLSHNNFS 927
            ||:|.:|.|..|:|....::..:...|:|  |::..:.|:
Zfish   739 LTSLTQLELRGNRLECLPVELGECRLLKRSGLIVEDSIFN 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380 6/22 (27%)
LRR_8 325..384 CDD:290566 10/58 (17%)
leucine-rich repeat 327..350 CDD:275380 3/22 (14%)
leucine-rich repeat 351..461 CDD:275380 26/144 (18%)
LRR_8 373..433 CDD:290566 14/94 (15%)
LRR_RI 397..648 CDD:238064 64/285 (22%)
leucine-rich repeat 399..422 CDD:275380 8/51 (16%)
leucine-rich repeat 462..485 CDD:275380 7/27 (26%)
LRR_8 465..520 CDD:290566 13/59 (22%)
leucine-rich repeat 486..509 CDD:275380 3/22 (14%)
LRR_8 508..567 CDD:290566 14/58 (24%)
leucine-rich repeat 510..533 CDD:275380 4/22 (18%)
LRR_RI 527..785 CDD:238064 74/290 (26%)
leucine-rich repeat 534..556 CDD:275380 5/21 (24%)
LRR_8 555..613 CDD:290566 18/58 (31%)
leucine-rich repeat 557..580 CDD:275380 9/23 (39%)
leucine-rich repeat 581..604 CDD:275380 4/22 (18%)
LRR_8 604..663 CDD:290566 17/58 (29%)
leucine-rich repeat 605..628 CDD:275380 4/22 (18%)
leucine-rich repeat 629..652 CDD:275380 8/22 (36%)
LRR_8 652..711 CDD:290566 21/89 (24%)
leucine-rich repeat 653..676 CDD:275380 5/22 (23%)
leucine-rich repeat 677..700 CDD:275380 9/53 (17%)
leucine-rich repeat 701..748 CDD:275380 12/46 (26%)
leucine-rich repeat 725..736 CDD:275378 2/10 (20%)
leucine-rich repeat 749..772 CDD:275380 4/23 (17%)
LRR_8 771..831 CDD:290566 21/59 (36%)
leucine-rich repeat 773..793 CDD:275380 9/19 (47%)
LRR_RI 804..1076 CDD:238064 31/126 (25%)
LRR_8 821..903 CDD:290566 22/81 (27%)
leucine-rich repeat 821..844 CDD:275380 6/22 (27%)
leucine-rich repeat 845..868 CDD:275380 0/22 (0%)
leucine-rich repeat 869..892 CDD:275380 10/22 (45%)
leucine-rich repeat 893..915 CDD:275380 5/21 (24%)
leucine-rich repeat 916..944 CDD:275380 4/14 (29%)
leucine-rich repeat 945..968 CDD:275380
LRR_8 967..1027 CDD:290566
leucine-rich repeat 969..992 CDD:275380
leucine-rich repeat 993..1014 CDD:275380
LRR_8 1015..1075 CDD:290566
leucine-rich repeat 1017..1040 CDD:275380
leucine-rich repeat 1041..1064 CDD:275380
LRR_RI <1047..1244 CDD:238064
LRR_8 1063..1125 CDD:290566
leucine-rich repeat 1089..1114 CDD:275380
leucine-rich repeat 1115..1162 CDD:275380
LRR_8 1163..1219 CDD:290566
leucine-rich repeat 1163..1186 CDD:275380
leucine-rich repeat 1187..1210 CDD:275380
leucine-rich repeat 1211..1233 CDD:275380
leucine-rich repeat 1234..1257 CDD:275380
LRR_8 1235..1292 CDD:290566
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
lrrc8abXP_005165659.1 Pannexin_like 1..326 CDD:289311 41/201 (20%)
leucine-rich repeat 434..456 CDD:275380 5/21 (24%)
leucine-rich repeat 457..480 CDD:275380 9/23 (39%)
leucine-rich repeat 481..503 CDD:275380 4/22 (18%)
leucine-rich repeat 504..531 CDD:275380 12/46 (26%)
LRR_RI <569..775 CDD:238064 65/258 (25%)
LRR_8 578..637 CDD:290566 20/82 (24%)
leucine-rich repeat 579..601 CDD:275380 4/21 (19%)
leucine-rich repeat 602..626 CDD:275380 11/35 (31%)
leucine-rich repeat 627..649 CDD:275380 4/34 (12%)
LRR_8 649..706 CDD:290566 21/58 (36%)
leucine-rich repeat 650..672 CDD:275380 9/22 (41%)
leucine-rich repeat 673..695 CDD:275380 8/22 (36%)
LRR_8 695..752 CDD:290566 22/82 (27%)
leucine-rich repeat 696..718 CDD:275380 6/21 (29%)
leucine-rich repeat 719..741 CDD:275380 10/22 (45%)
leucine-rich repeat 742..762 CDD:275380 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
00.000

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