DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and lrrc8da

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:XP_002660860.1 Gene:lrrc8da / 497399 ZFINID:ZDB-GENE-061009-26 Length:825 Species:Danio rerio


Alignment Length:533 Identity:138/533 - (25%)
Similarity:227/533 - (42%) Gaps:128/533 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   754 LKDNQLTRV-ERSFFADTP--------------QLGRLY----------LSDNKIRDIEKD---T 790
            ||:....:| |.|.|:|.|              |..:||          :|:||:|:|..:   |
Zfish   368 LKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWT 432

  Fly   791 FVNLLLLQFLDLSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGY--AFAKLKNLKSLDLSHN 853
            |                .:||:......|:.:||     |:..:.|.  |...|.:|:.|.|...
Zfish   433 F----------------EKLRQHVSTNAQEEQEL-----HLFMLSGLPNAVFDLTDLEILKLELI 476

  Fly   854 PLVQLTRDIFSNEFPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLDIPN--- 915
            |.|:::..: |....|..|:|.:|. .|:||.||..|         |:.|....|:..|:..   
Zfish   477 PEVRISAKV-SQMTNLRELHLYHCP-AKVEQTAFTFL---------RDHLRCLHIKFTDVAEIPP 530

  Fly   916 ----LRRL----LLSHNNFSYAGSVGIMAGMLDRLRSLQQLSMSNCSLGQIPDLLFAKNTNLVRL 972
                ||.|    |..:.|..:...:|:.:  |..||.|:.|.:.: :|.:||..|...:.:||:|
Zfish   531 WIYLLRSLKELNLFGNLNSEHNKMIGLES--LRDLRHLRTLYLKS-NLNKIPSNLTDLSPHLVKL 592

  Fly   973 DLCDNRLTQINRNIFSGLNVFKELRLCRNELSDFPHIALYNLSTLESLDLARNQLASIDFFKLSG 1037
            .:.::....:..|....:....:|.|...:|...|| ::::|:.|:.|||..|.:.:|:  ::..
Zfish   593 VIHNDGTKLLVMNSLKKMTSLVDLELHNCDLERIPH-SIFSLANLQELDLKNNNIRTIE--EIIS 654

  Fly  1038 TLNLRQLI---LRDNKITALSGFNAVNLTQ-LDSVDLSGNLLLSLPANFLRHSINLQKVHLSNNR 1098
            ..:||:|:   |..|||:.:.  .::.|.: |:|:.:..|.:.:||.: |.|...|:.:.||||.
Zfish   655 FQHLRRLVCLKLWYNKISIIP--PSIGLVKSLESLIICHNKVENLPPS-LFHLPKLRHIDLSNNS 716

  Fly  1099 FLQIPSSALSDVSIPRLSWLN---LTGNPINRIYTVKEERYPYLKELYICQTNLSILTSKDFEAF 1160
            ...||      |.|..|..|.   :|||        |.|..|  .:|:.|        ||     
Zfish   717 ISNIP------VEIGLLHNLQHFAITGN--------KVEVLP--SQLFKC--------SK----- 752

  Fly  1161 QALQHLHLVNNRITRISPGAFKSLTNLLTLDLSVNELEMLPKERLQGLRLLRFLNISHNTLKDLE 1225
              |:.|.:.:|.||.| |.:...|..|..|:|..|.|:.||.: |...:|||      ..|..:|
Zfish   753 --LKVLCVGHNNITSI-PDSIGQLVQLSHLELKGNCLDCLPFQ-LGQCQLLR------KNLLFVE 807

  Fly  1226 EFSVDLLEMQTLD 1238
            :...|.|.::..|
Zfish   808 DHLFDTLPIEVKD 820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380
LRR_8 325..384 CDD:290566
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380
LRR_8 373..433 CDD:290566
LRR_RI 397..648 CDD:238064
leucine-rich repeat 399..422 CDD:275380
leucine-rich repeat 462..485 CDD:275380
LRR_8 465..520 CDD:290566
leucine-rich repeat 486..509 CDD:275380
LRR_8 508..567 CDD:290566
leucine-rich repeat 510..533 CDD:275380
LRR_RI 527..785 CDD:238064 14/55 (25%)
leucine-rich repeat 534..556 CDD:275380
LRR_8 555..613 CDD:290566
leucine-rich repeat 557..580 CDD:275380
leucine-rich repeat 581..604 CDD:275380
LRR_8 604..663 CDD:290566
leucine-rich repeat 605..628 CDD:275380
leucine-rich repeat 629..652 CDD:275380
LRR_8 652..711 CDD:290566
leucine-rich repeat 653..676 CDD:275380
leucine-rich repeat 677..700 CDD:275380
leucine-rich repeat 701..748 CDD:275380
leucine-rich repeat 725..736 CDD:275378
leucine-rich repeat 749..772 CDD:275380 8/32 (25%)
LRR_8 771..831 CDD:290566 16/86 (19%)
leucine-rich repeat 773..793 CDD:275380 9/32 (28%)
LRR_RI 804..1076 CDD:238064 71/288 (25%)
LRR_8 821..903 CDD:290566 23/83 (28%)
leucine-rich repeat 821..844 CDD:275380 6/24 (25%)
leucine-rich repeat 845..868 CDD:275380 6/22 (27%)
leucine-rich repeat 869..892 CDD:275380 10/22 (45%)
leucine-rich repeat 893..915 CDD:275380 4/21 (19%)
leucine-rich repeat 916..944 CDD:275380 8/31 (26%)
leucine-rich repeat 945..968 CDD:275380 6/22 (27%)
LRR_8 967..1027 CDD:290566 15/59 (25%)
leucine-rich repeat 969..992 CDD:275380 4/22 (18%)
leucine-rich repeat 993..1014 CDD:275380 5/20 (25%)
LRR_8 1015..1075 CDD:290566 17/63 (27%)
leucine-rich repeat 1017..1040 CDD:275380 6/22 (27%)
leucine-rich repeat 1041..1064 CDD:275380 8/25 (32%)
LRR_RI <1047..1244 CDD:238064 56/196 (29%)
LRR_8 1063..1125 CDD:290566 21/65 (32%)
leucine-rich repeat 1089..1114 CDD:275380 9/24 (38%)
leucine-rich repeat 1115..1162 CDD:275380 12/49 (24%)
LRR_8 1163..1219 CDD:290566 19/55 (35%)
leucine-rich repeat 1163..1186 CDD:275380 8/22 (36%)
leucine-rich repeat 1187..1210 CDD:275380 8/22 (36%)
leucine-rich repeat 1211..1233 CDD:275380 5/21 (24%)
leucine-rich repeat 1234..1257 CDD:275380 1/5 (20%)
LRR_8 1235..1292 CDD:290566 1/4 (25%)
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
lrrc8daXP_002660860.1 Pannexin_like 1..360 CDD:289311
leucine-rich repeat 491..533 CDD:275380 14/51 (27%)
LRR_RI <538..786 CDD:238064 77/288 (27%)
leucine-rich repeat 538..565 CDD:275380 6/28 (21%)
leucine-rich repeat 566..612 CDD:275380 10/46 (22%)
LRR_8 611..671 CDD:290566 17/62 (27%)
leucine-rich repeat 613..635 CDD:275380 6/22 (27%)
leucine-rich repeat 636..660 CDD:275380 7/25 (28%)
leucine-rich repeat 661..683 CDD:275380 6/23 (26%)
LRR_8 682..740 CDD:290566 21/72 (29%)
leucine-rich repeat 684..706 CDD:275380 7/22 (32%)
leucine-rich repeat 707..729 CDD:275380 10/27 (37%)
LRR_8 729..784 CDD:290566 22/80 (28%)
leucine-rich repeat 730..752 CDD:275380 9/39 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
00.000

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