DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and kek6

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_001263151.1	Gene:	kek6 / 43729	FlyBaseID:	FBgn0039862	Length:	843	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	118/581 - (20%)
Similarity:	201/581 - (34%)	Gaps:	192/581 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1105 SALSDVSIPRLSWLNLTGNPINRIYTVKEERYPYL-KELYICQTNLSILTSKDFEAFQALQHLHL 1168
            |:|...:||......|      ::..:.:...||| :|.:   :.|.:|.         ||.::|
  Fly    56 SSLQLTTIPNTLSTEL------QVLVLNDNHIPYLNREEF---STLGLLN---------LQRIYL 102

  Fly  1169 VNNRITRISPGAFKSLTNLLTLDLSVNELEMLPKERLQGLRLLRFLNISHNTLKDLEEFSVDLL- 1232
            ..:.:..|...:|::|..|:.:|||.|:||||.|:...|...||.|.::.|.||.|..:...:|
  Fly   103 KKSEVQYIHKESFRNLKILVEIDLSDNKLEMLDKDTFMGNDRLRILYLNGNPLKRLAAYQFPILP 167

  Fly  1233 EMQTLDLSFNQLDRISKKTFRNLHGLLELFLMGNRMTVLSNDAFRFLRKLHVLDLRKNYFELVPL 1297
            .::|||:....:..|...:..||:.|..|.|..|.:..||...|:.:
  Fly   168 HLRTLDMHDCLISYIDPMSLANLNLLEFLNLKNNLLESLSEYVFQHM------------------ 214

  Fly  1298 EPLRPLETNLRTLRLEENPLHCSCDAQKLWEWLRDHRKWSLSMGSGAGRGIGGLTGGLGGDSINY 1362
                   .||:||.|||||..|:|..:|...|..:.|..|:|
  Fly   215 -------ANLKTLSLEENPWQCNCKLRKFRGWYVNSRLSSVS----------------------- 249

  Fly  1363 LRCEHPTELRGKVFGRMEPQQFCDAPLIPKMAIQDIQPYSVVVSWQSRDHLGLNGFEIVYHATGD 1427
            |.|:.|...:.:.:..::.:.|...|.:.....:::|...:          |.|        |..
  Fly   250 LVCKGPPAQKDRTWDSVDDELFGCPPRVEIFNNEEVQNIDI----------GSN--------TTF 296

  Fly  1428 GLVTAGSPTSRERDSLRDIHDPERQRTRDQARERSRERDRDRERDRERFSIATDEIHGKRLNG-- 1490
            ..:..|.|.            ||                            ...|::||.|:.
  Fly   297 SCLVYGDPL------------PE----------------------------VAWELNGKILDNDN 321

  Fly  1491 ---TASSTKLTKLSPN-TRYHICVIGSGNWLSEPLANALQRLHTNESLREEEAVM-MSAPLPESF 1550
               .:.|....||..| |.:::..:.:|.:.... :|::..:..|.|:...|.|. :....||:|
  Fly   322 VLFESESIASDKLWSNLTVFNVTSLDAGTYACTG-SNSIGSMTQNISIYLSEIVQHVLEKTPETF 385

  Fly  1551 ----------------------------SPYQHQHNRNSNGNANPAMVQDHNKKQNPDQDLDNVV 1587
                                        :..||:| .|..|..:.....|..||
  Fly   386 WYFGLIMGIFGTVFLLISISFVVCLCKRTTRQHRH-ANKAGVKSSVSFNDQEKK----------- 438

  Fly  1588 GQDNALMEVLKNSHISACT----DVQTLDSTPSLVTDENGLSSN-GF----IHSILTRRLG 1639
                     |.:|.::..|    |...:|:.|:.:....|.|:. ||    ||::.:.|.|
  Fly   439 ---------LLDSSVTTTTNDRGDSYGIDNQPTSIGMNKGDSAGMGFNQIEIHAVESHRHG 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		LRR_8	604..663	CDD:290566
		leucine-rich repeat	605..628	CDD:275380
		leucine-rich repeat	629..652	CDD:275380
		LRR_8	652..711	CDD:290566
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		LRR_8	771..831	CDD:290566
		leucine-rich repeat	773..793	CDD:275380
		LRR_RI	804..1076	CDD:238064
		LRR_8	821..903	CDD:290566
		leucine-rich repeat	821..844	CDD:275380
		leucine-rich repeat	845..868	CDD:275380
		leucine-rich repeat	869..892	CDD:275380
		leucine-rich repeat	893..915	CDD:275380
		leucine-rich repeat	916..944	CDD:275380
		leucine-rich repeat	945..968	CDD:275380
		LRR_8	967..1027	CDD:290566
		leucine-rich repeat	969..992	CDD:275380
		leucine-rich repeat	993..1014	CDD:275380
		LRR_8	1015..1075	CDD:290566
		leucine-rich repeat	1017..1040	CDD:275380
		leucine-rich repeat	1041..1064	CDD:275380
		LRR_RI	<1047..1244	CDD:238064	39/140 (28%)
		LRR_8	1063..1125	CDD:290566	5/19 (26%)
		leucine-rich repeat	1089..1114	CDD:275380	3/8 (38%)
		leucine-rich repeat	1115..1162	CDD:275380	7/47 (15%)
		LRR_8	1163..1219	CDD:290566	20/55 (36%)
		leucine-rich repeat	1163..1186	CDD:275380	6/22 (27%)
		leucine-rich repeat	1187..1210	CDD:275380	11/22 (50%)
		leucine-rich repeat	1211..1233	CDD:275380	8/22 (36%)
		leucine-rich repeat	1234..1257	CDD:275380	6/22 (27%)
		LRR_8	1235..1292	CDD:290566	13/56 (23%)
		leucine-rich repeat	1258..1279	CDD:275380	7/20 (35%)
		leucine-rich repeat	1282..1306	CDD:275380	0/23 (0%)
kek6	NP_001263151.1	leucine-rich repeat	71..96	CDD:275380	6/33 (18%)
		LRR_8	96..155	CDD:290566	21/67 (31%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	11/22 (50%)
		LRR_4	144..186	CDD:289563	12/41 (29%)
		leucine-rich repeat	145..168	CDD:275380	8/22 (36%)
		leucine-rich repeat	169..216	CDD:275380	13/71 (18%)
		LRRCT	225..274	CDD:214507	13/71 (18%)
		Ig	295..367	CDD:143165	16/112 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453693
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930