DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and CG5810

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_650952.2	Gene:	CG5810 / 42513	FlyBaseID:	FBgn0038866	Length:	428	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	104/447 - (23%)
Similarity:	172/447 - (38%)	Gaps:	107/447 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 ELPADAF--TNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRSNFIPLLPVTLFDKSTKLTS 631
            |:..|:.  ..:|..::.|..::|:|:...||...|...:.|.|.|:.:..||..:|....:|..
  Fly    27 EIAIDSLDCRENTCTNLKYPSASAVAYFSENVTKHLRKYETLVLHSSDLANLPRKIFLNLPQLVE 91

  Fly   632 LSLDNNEIQDLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQELHIQKNSIEDIEPQAFH 696
            ..:...|:|.:|...|...::|:.:....|.:|.:....||....|:||::..|.:||:....|.
  Fly    92 FHVLECELQQIESVCFDGAKNLKRLNFGGNALRVLDSNTFELATQLEELNLSDNQLEDLPTTIFR 156

  Fly   697 TLENMQHINLQDNQLTVLEDIFPDENSSLLSVQLEANYLHKVHPRTFSRQQK-VQIMWLKDNQLT 760
            .|:|:|.|||.:|:|..|......:..||.|:.:::|.|.::....|..|:| :.....:.|||.
  Fly   157 PLKNLQKINLSNNRLITLSQHIFSQLGSLKSINVDSNQLVELPGELFRDQRKHLSEFSAQSNQLV 221

  Fly   761 RVERSFFAD--------TPQLGRLYLSDNKIRDIEKDTFVNLLLLQFLDLSGNQLRQLRRDYFAP 817
            |:..:.|.:        .|||.||:|| .||.::|                            |.
  Fly   222 RIPFNIFREIDHLSLSFNPQLRRLHLS-AKINELE----------------------------AT 257

  Fly   818 LQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLNLGNCSLRKL 882
            ..|||.:.| ...:..::..|..||..||         :...:|:
  Fly   258 NCDLESVEL-DGRVIGVQLEANPKLHELK---------ISQPQDL-------------------- 292

  Fly   883 EQHAFKSLTNLNELNLERNQLNPADIQTLDIPNLRRLL-------LSHNNFSYAGSVGIMAGMLD 940
             :|.:.:.|||..|:.........|:...||.||..|.       |...:|:|.........||.
  Fly   293 -EHLYLANTNLYRLDFLSKASKLVDLDVTDIVNLADLPKITSAKGLERLSFTYDNLTSNHMDMLP 356

  Fly   941 RLRSLQQLSMS-----------------------NCSLGQIPDLL----FAKNTNLV 970
            .|:.|..|.:|                       ||  ||:.|||    ..|:|.::
  Fly   357 HLKDLNYLEISHEKGKEIFIKDLDEDFFVEEAELNC--GQLADLLEFVELPKDTTIL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064	19/80 (24%)
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064	63/226 (28%)
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566	11/45 (24%)
		leucine-rich repeat	557..580	CDD:275380	2/12 (17%)
		leucine-rich repeat	581..604	CDD:275380	6/22 (27%)
		LRR_8	604..663	CDD:290566	13/58 (22%)
		leucine-rich repeat	605..628	CDD:275380	6/22 (27%)
		leucine-rich repeat	629..652	CDD:275380	5/22 (23%)
		LRR_8	652..711	CDD:290566	19/58 (33%)
		leucine-rich repeat	653..676	CDD:275380	5/22 (23%)
		leucine-rich repeat	677..700	CDD:275380	8/22 (36%)
		leucine-rich repeat	701..748	CDD:275380	14/46 (30%)
		leucine-rich repeat	725..736	CDD:275378	3/10 (30%)
		leucine-rich repeat	749..772	CDD:275380	5/30 (17%)
		LRR_8	771..831	CDD:290566	15/59 (25%)
		leucine-rich repeat	773..793	CDD:275380	8/19 (42%)
		LRR_RI	804..1076	CDD:238064	40/201 (20%)
		LRR_8	821..903	CDD:290566	14/81 (17%)
		leucine-rich repeat	821..844	CDD:275380	6/22 (27%)
		leucine-rich repeat	845..868	CDD:275380	3/22 (14%)
		leucine-rich repeat	869..892	CDD:275380	1/22 (5%)
		leucine-rich repeat	893..915	CDD:275380	5/21 (24%)
		leucine-rich repeat	916..944	CDD:275380	8/34 (24%)
		leucine-rich repeat	945..968	CDD:275380	11/49 (22%)
		LRR_8	967..1027	CDD:290566	1/4 (25%)
		leucine-rich repeat	969..992	CDD:275380	0/2 (0%)
		leucine-rich repeat	993..1014	CDD:275380
		LRR_8	1015..1075	CDD:290566
		leucine-rich repeat	1017..1040	CDD:275380
		leucine-rich repeat	1041..1064	CDD:275380
		LRR_RI	<1047..1244	CDD:238064
		LRR_8	1063..1125	CDD:290566
		leucine-rich repeat	1089..1114	CDD:275380
		leucine-rich repeat	1115..1162	CDD:275380
		LRR_8	1163..1219	CDD:290566
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
CG5810	NP_650952.2	leucine-rich repeat	65..88	CDD:275380	6/22 (27%)
		LRR_8	87..147	CDD:290566	14/59 (24%)
		leucine-rich repeat	89..112	CDD:275380	5/22 (23%)
		leucine-rich repeat	113..136	CDD:275380	5/22 (23%)
		LRR_8	135..195	CDD:290566	20/59 (34%)
		LRR_4	135..175	CDD:289563	15/39 (38%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		leucine-rich repeat	185..209	CDD:275380	6/23 (26%)
		leucine-rich repeat	210..231	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453617
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940