DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and CG18249

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	119/502 - (23%)
Similarity:	188/502 - (37%)	Gaps:	149/502 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   653 LREVRLHNNRIRRVRRGVFEPLPSLQELHIQKNSIEDIEPQAFHTLENMQHINLQDNQLTVLEDI 717
            |||:.|.|...:.:...|.:..|.|:.|.|:..:...|..::...:||:..:.:|...|.||.|.
  Fly    57 LRELHLRNCSRQSITWLVLQLTPGLRTLVIRNCATYHISKESLRPVENLTSLQMQGTSLGVLRDQ 121

  Fly   718 FPDENSSLLSVQLEANYLHKVHPRTFSRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYLSDNK 782
            ..:....|..:||..|::|.||...|....|
  Fly   122 IFNAVPRLEILQLSQNFIHTVHVAAFQGLSK---------------------------------- 152

  Fly   783 IRDIEKDTFVNLLLLQFLDLSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKS 847
                          |:.|.|.||.:.::......||.:|..|.|:||.:..:....|||.|.|::
  Fly   153 --------------LRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQT 203

  Fly   848 LDLSHNPLVQLTRDIFSNEFPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLD 912
            |.|:.|||..|..|:..:...|..|:||:.:                ||          ::.||:
  Fly   204 LLLNGNPLRILMPDVLGSLPNLRLLDLGHAA----------------EL----------EVMTLN 242

  Fly   913 IPNLRRLLLSHNNFSYAGSVGIMAGMLDRLRSLQQLSMSNCSLGQIPDLLFAKNTNLVRLDLCDN 977
            :.|::.|:|..::.|   |:.|..|
  Fly   243 LTNVQNLVLEGSSLS---SLVINGG---------------------------------------- 264

  Fly   978 RLTQINRNIFSGLNVFKELRLCRNELSDFPHIALYNLSTLESLDLARNQLASIDFFK-LSGTLNL 1041
                           |.:|:...|||:   |:.:.|.|::..:||..|.|...|... |.|..||
  Fly   265 ---------------FIKLQAGNNELN---HLQVGNKSSVIEMDLHGNLLNGNDTAALLRGMWNL 311

  Fly  1042 RQLILRDNKITAL----SGFNA------VNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVHLSN 1096
            ::|.|..|:|.||    ||.:|      :.|..|..::|:.|.|:.||......|..|..:.||:
  Fly   312 QRLDLSKNRIEALPQHGSGLDASGTQELLILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSH 376

  Fly  1097 NRFLQIPSSALSDVSIPRLSWLNLTGNPINRI-YTVKEERYPYLKEL 1142
            |..|.:..:.|..:|:  |..|.:.||.:|.| |....|.:|.|.||
  Fly   377 NLMLTLDVAILRSLSV--LKGLYVEGNRLNTINYQKLHEEHPDLSEL 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064	27/131 (21%)
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		LRR_8	604..663	CDD:290566	5/9 (56%)
		leucine-rich repeat	605..628	CDD:275380
		leucine-rich repeat	629..652	CDD:275380
		LRR_8	652..711	CDD:290566	14/57 (25%)
		leucine-rich repeat	653..676	CDD:275380	6/22 (27%)
		leucine-rich repeat	677..700	CDD:275380	4/22 (18%)
		leucine-rich repeat	701..748	CDD:275380	13/46 (28%)
		leucine-rich repeat	725..736	CDD:275378	4/10 (40%)
		leucine-rich repeat	749..772	CDD:275380	0/22 (0%)
		LRR_8	771..831	CDD:290566	12/59 (20%)
		leucine-rich repeat	773..793	CDD:275380	0/19 (0%)
		LRR_RI	804..1076	CDD:238064	66/282 (23%)
		LRR_8	821..903	CDD:290566	23/81 (28%)
		leucine-rich repeat	821..844	CDD:275380	8/22 (36%)
		leucine-rich repeat	845..868	CDD:275380	8/22 (36%)
		leucine-rich repeat	869..892	CDD:275380	4/22 (18%)
		leucine-rich repeat	893..915	CDD:275380	4/21 (19%)
		leucine-rich repeat	916..944	CDD:275380	6/27 (22%)
		leucine-rich repeat	945..968	CDD:275380	0/22 (0%)
		LRR_8	967..1027	CDD:290566	11/59 (19%)
		leucine-rich repeat	969..992	CDD:275380	0/22 (0%)
		leucine-rich repeat	993..1014	CDD:275380	6/20 (30%)
		LRR_8	1015..1075	CDD:290566	23/70 (33%)
		leucine-rich repeat	1017..1040	CDD:275380	7/23 (30%)
		leucine-rich repeat	1041..1064	CDD:275380	11/32 (34%)
		LRR_RI	<1047..1244	CDD:238064	34/107 (32%)
		LRR_8	1063..1125	CDD:290566	18/61 (30%)
		leucine-rich repeat	1089..1114	CDD:275380	7/24 (29%)
		leucine-rich repeat	1115..1162	CDD:275380	12/29 (41%)
		LRR_8	1163..1219	CDD:290566
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	6/22 (27%)
		LRR_8	104..163	CDD:290566	20/106 (19%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		LRR_RI	107..438	CDD:238064	106/452 (23%)
		leucine-rich repeat	129..152	CDD:275380	8/22 (36%)
		leucine-rich repeat	153..176	CDD:275380	7/22 (32%)
		LRR_8	176..232	CDD:290566	20/55 (36%)
		leucine-rich repeat	177..200	CDD:275380	8/22 (36%)
		leucine-rich repeat	201..224	CDD:275380	8/22 (36%)
		leucine-rich repeat	225..258	CDD:275380	12/61 (20%)
		leucine-rich repeat	259..310	CDD:275380	17/108 (16%)
		leucine-rich repeat	311..344	CDD:275380	11/32 (34%)
		LRR_8	343..403	CDD:290566	18/61 (30%)
		leucine-rich repeat	345..368	CDD:275380	7/22 (32%)
		leucine-rich repeat	369..390	CDD:275380	6/20 (30%)
		leucine-rich repeat	393..417	CDD:275380	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840