DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and caps

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	972	Identity:	206/972 - (21%)
Similarity:	319/972 - (32%)	Gaps:	354/972 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   910 TLDI------PNLRRLLLSHNNFSYAGSVGIMAGMLDRLRSLQ---QLSMSNCSLGQ---IPDLL 962
            |||:      |.::||::.:|......|            |:|   ||:..:.|...   ||:..
  Fly    62 TLDVLPIALNPAIQRLVIKNNKLKTIDS------------SMQFYAQLTFLDLSFNDMLTIPERS 114

  Fly   963 FAKNTNLVRLDLCDNRLTQINRNIFSGLNVFKELRLCRNELSDFPHIALYNLSTLESLDLARNQL 1027
            ||.:..|..|.|..|::.|::...|.||:....|.|..|.:::..:.....:..|..|:|.:|::
  Fly   115 FAYHAKLQELHLDHNKIGQVSNKTFLGLSTISVLNLRGNLIAELEYRTFSPMVKLAELNLGQNRI 179

  Fly  1028 ASIDFFKLSGTLNLRQLILRDNKITALSG---FNAVNLTQLDSVDLSGNLLLSLPANFLRHSINL 1089
            :.||...|.|..|||.|.|.||.:|.:.|   |.|:                        ||  |
  Fly   180 SHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQAL------------------------HS--L 218

  Fly  1090 QKVHLSNNRFLQIPSSALSDV----------------------SIPRLSWLNLTGNPINRIYTVK 1132
            .:::|..|.|:.||..|..|:                      .:..|.:|:|:.|.:..|.|..
  Fly   219 AELYLGTNSFMTIPGGAFQDLKGLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAA 283

  Fly  1133 EERYPYLKELYICQTNLSILTSKDFEAFQALQHLHLVN-NRITRISPGAFKSLTNLLTLDLSVN- 1195
            .:|...|::|.|.|.:..:::|..|...:.|:||.|.. .|:.|:..|||...|||..|:||.|
  Fly   284 FQRLGRLEQLNIGQNDFEVISSGAFSGLRELRHLELTGAQRLRRVESGAFSGNTNLEHLNLSSNK 348

  Fly  1196 ELEMLPKERLQGLRLLRFLNISHNTLKDLEEFSVDLLEMQTLDLSFNQLDRISKKTFRNLHGLLE 1260
            :|..|....|.||..|..:.:..|.|..|:|..|...::||||||
  Fly   349 QLNELSSIALGGLPHLSTVVLKANQLSSLDEGLVPWADLQTLDLS-------------------- 393

  Fly  1261 LFLMGNRMTVLSNDAFRFLRKLHVLDLRKNYFELVPLEPLRPLETNLRTLRLEENPLHCSCDAQK 1325
                                                                 |||..|.|...
  Fly   394 -----------------------------------------------------ENPFECDCRLL- 404

  Fly  1326 LWEWLRDHRKWSLSMGSGAGRGIGGLTGGLGGDSINY--LRCEHPTELRGKVFGRM-EPQQFCDA 1387
               ||| |...|        |...|          .|  :.|.:||.||......: ||...|..
  Fly   405 ---WLR-HLLVS--------RNASG----------QYAPVICAYPTALRDLPLAHLAEPLLGCAH 447

  Fly  1388 PLIPKMAIQDIQPYSVVVSWQSRDHLGLNGFEIVYHATGDGLVTAGSPTSRERDSLRDIHDPERQ 1452
            ....|.||..|    :||:..:                   |:|          :|..:....|.
  Fly   448 GAASKQAIIGI----LVVACAA-------------------LIT----------TLALVLYTCRH 479

  Fly  1453 RTRDQARERSRERDRDRERDRERFSIATDEIHGKR-----------------LNGTASSTKLTKL 1500
            |.|:..:..|....::||. ::.||   ||.:..|                 :.|.:....:|:|
  Fly   480 RIREMLKGHSALGRKEREY-QKTFS---DEEYMSRPPPGGGGVHPAAGGYPYIAGNSRMIPVTEL 540

  Fly  1501 S------PNTRYHICVIGSGNWLSEPLANALQRLHTNESLREEEAVMMSAPLPESFSPYQHQHNR 1559
            .      |..|..    |.|...| ..:.|:|:|....::.:..         .||:...|.|..
  Fly   541 XLEAPPPPQLRGR----GGGGGAS-TASGAVQQLQVPSAVDQAS---------NSFAQLSHIHYM 591

  Fly  1560 NSNGNANPAMVQDHNKKQNPDQDLDNVVGQDNALMEVLKNSHISACTDVQTLDSTPSL------V 1618
            .:||....|..|....|.:..|       ||..|:         ||...:.|::| ||      |
  Fly   592 TNNGQQQQAQQQQSTSKMHHSQ-------QDMRLL---------ACNGGKPLNAT-SLPRHRPPV 639

  Fly  1619 TDENGLS------SNGFIHSILTRRLGLIVGCCLGIIVFIVMISVLSYVKLKKKRIENAKRQA-- 1675
            ..|:.||      :||                                ::|.:....:.:.|:
  Fly   640 VQESTLSHYSQPLANG--------------------------------IRLTQDHFNHNQNQSHN 672

  Fly  1676 -------ALP------PEYI-SYRHFSIP-NEEL--------------TRTAANAGTVAAAAAAN 1711
                   |.|      |.|| :..|:|:| :.:|              .|.......:.......
  Fly   673 QHYGGVYAKPCDAMSEPGYIHNNSHYSLPLDHDLPPSPTPTPPPPALPLRNGVGMALIHGNTTGR 737

  Fly  1712 NSHNSNNSTDEGSSPHMSSVPSGISAHISGTSLSTGGT------------GTGSTTTTATTP 1761
            .|.|:||:....|:.:...:..|:...:.||..:..|:            ||...|...|.|
  Fly   738 RSFNNNNNVSTLSNNNHHGIGGGVGVAVGGTVGNNNGSLRRYHXYPAKTCGTLGRTIIKTRP 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		LRR_8	604..663	CDD:290566
		leucine-rich repeat	605..628	CDD:275380
		leucine-rich repeat	629..652	CDD:275380
		LRR_8	652..711	CDD:290566
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		LRR_8	771..831	CDD:290566
		leucine-rich repeat	773..793	CDD:275380
		LRR_RI	804..1076	CDD:238064	47/180 (26%)
		LRR_8	821..903	CDD:290566
		leucine-rich repeat	821..844	CDD:275380
		leucine-rich repeat	845..868	CDD:275380
		leucine-rich repeat	869..892	CDD:275380
		leucine-rich repeat	893..915	CDD:275380	3/10 (30%)
		leucine-rich repeat	916..944	CDD:275380	4/27 (15%)
		leucine-rich repeat	945..968	CDD:275380	8/28 (29%)
		LRR_8	967..1027	CDD:290566	15/59 (25%)
		leucine-rich repeat	969..992	CDD:275380	8/22 (36%)
		leucine-rich repeat	993..1014	CDD:275380	3/20 (15%)
		LRR_8	1015..1075	CDD:290566	19/62 (31%)
		leucine-rich repeat	1017..1040	CDD:275380	8/22 (36%)
		leucine-rich repeat	1041..1064	CDD:275380	10/25 (40%)
		LRR_RI	<1047..1244	CDD:238064	62/223 (28%)
		LRR_8	1063..1125	CDD:290566	14/83 (17%)
		leucine-rich repeat	1089..1114	CDD:275380	8/46 (17%)
		leucine-rich repeat	1115..1162	CDD:275380	13/46 (28%)
		LRR_8	1163..1219	CDD:290566	22/57 (39%)
		leucine-rich repeat	1163..1186	CDD:275380	9/23 (39%)
		leucine-rich repeat	1187..1210	CDD:275380	10/23 (43%)
		leucine-rich repeat	1211..1233	CDD:275380	6/21 (29%)
		leucine-rich repeat	1234..1257	CDD:275380	6/22 (27%)
		LRR_8	1235..1292	CDD:290566	6/56 (11%)
		leucine-rich repeat	1258..1279	CDD:275380	0/20 (0%)
		leucine-rich repeat	1282..1306	CDD:275380	0/23 (0%)
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	6/32 (19%)
		LRR_8	96..155	CDD:290566	18/58 (31%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	8/22 (36%)
		LRR_8	143..201	CDD:290566	16/57 (28%)
		leucine-rich repeat	145..168	CDD:275380	3/22 (14%)
		LRR_RI	147..397	CDD:238064	80/348 (23%)
		leucine-rich repeat	169..192	CDD:275380	8/22 (36%)
		leucine-rich repeat	193..217	CDD:275380	10/47 (21%)
		LRR_8	217..276	CDD:290566	13/60 (22%)
		leucine-rich repeat	218..241	CDD:275380	8/22 (36%)
		leucine-rich repeat	242..265	CDD:275380	0/22 (0%)
		LRR_8	265..321	CDD:290566	17/55 (31%)
		leucine-rich repeat	266..289	CDD:275380	7/22 (32%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		LRR_8	312..374	CDD:290566	23/61 (38%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..363	CDD:275380	10/23 (43%)
		LRRCT	395..445	CDD:214507	19/72 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940