DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and CG18480

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	114/503 - (22%)
Similarity:	178/503 - (35%)	Gaps:	164/503 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1152 LTSKDFEAFQALQHLHLVNNRITRISPGAFKSLTNLLTLDLSVNELEMLPKERLQGLRLLRFLNI 1216
            |.|.:.|....::.|.|..|.||.|...:||:..:||.|.|:.|.:..|..:....|..||:|::
  Fly    65 LISANIEIPTTVELLDLSYNDITTIDDDSFKTTIHLLNLTLAHNAIHTLYGDAFVELTRLRYLDL 129

  Fly  1217 SHNTLKDLEEFSVDLLEMQT----LDLSFNQLDRISKKTFRNLHGLLELFLMGNRMTVLSNDAFR 1277
            |:|.|:.::|   .:||...    |:|..|:|..:.|........|..|.|..:::..|......
  Fly   130 SYNRLEQIDE---HILESNNQLIHLNLEGNKLSTLGKGPILRSPSLRSLNLRNSQVNQLGTQLLS 191

  Fly  1278 FLRKLHVLDLRKNYFELVPLEP---LRPLETNLRTLRLEENPLHCSCDAQKLWEWLRDHRKWSLS 1339
            .|.:|..|||.:|.  |:.|.|   ..|  .||.:|.:||||.:|.....|:...||.
  Fly   192 ALPQLRQLDLAQNL--LLTLSPGDFHAP--RNLASLNVEENPFNCDRALAKVATGLRQ------- 245

  Fly  1340 MGSGAGRGIGGLTGGLGGDSINYLRCEHPTELRGKVFGRMEPQQFCDAPLIPKMAIQDIQPYSVV 1404
                  ||:          :|....|             ||.:            :||.|..:..
  Fly   246 ------RGV----------AIFMSNC-------------MEEE------------VQDHQDDAEA 269

  Fly  1405 VSWQSRDHLGLNGFEIVYHATGDGLVTAGSPTSRERDSL----RDIHDPERQRTRDQARERSRER 1465
            |::.:::    ..||.:.:.         .|::|...|:    ||:...|.|.:
  Fly   270 VNFPNKN----EKFESMEYL---------EPSTRGPQSVLSVWRDLDSSEEQNS----------- 310

  Fly  1466 DRDRERDRERFSIATDEIHGKRLNGTASSTKLTKLSPNTRYHIC-------VIGSGNWLSEPLAN 1523
                .:|.|:.|..:|...|.|          .||.  .||.||       ::..||   ..|.:
  Fly   311 ----SQDDEQMSSLSDVCEGSR----------EKLC--LRYRICLERVSHELLAGGN---SQLED 356

  Fly  1524 ALQRLHTNE---------------------------------SLRE-----EEAVMMSAPLPES- 1549
            .:.|.||.:                                 .:|:     |.|..:||||..|
  Fly   357 EIIRTHTYDEDDLKLAFVVGGATGVCMVIFIITFALCLKSCCEMRKKKSNPEVATGVSAPLNPSQ 421

  Fly  1550 --------FSPYQHQHNRNSNGNANPAMVQDHNKKQNPDQDLDNVVGQ 1589
                    :||.:.::.|.||.. .|...|.|...:.|....||.|.:
  Fly   422 DSLPTIHTWSPQRTRNPRRSNPQ-RPRSTQSHAVVRQPYGPQDNFVSR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		LRR_8	604..663	CDD:290566
		leucine-rich repeat	605..628	CDD:275380
		leucine-rich repeat	629..652	CDD:275380
		LRR_8	652..711	CDD:290566
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		LRR_8	771..831	CDD:290566
		leucine-rich repeat	773..793	CDD:275380
		LRR_RI	804..1076	CDD:238064
		LRR_8	821..903	CDD:290566
		leucine-rich repeat	821..844	CDD:275380
		leucine-rich repeat	845..868	CDD:275380
		leucine-rich repeat	869..892	CDD:275380
		leucine-rich repeat	893..915	CDD:275380
		leucine-rich repeat	916..944	CDD:275380
		leucine-rich repeat	945..968	CDD:275380
		LRR_8	967..1027	CDD:290566
		leucine-rich repeat	969..992	CDD:275380
		leucine-rich repeat	993..1014	CDD:275380
		LRR_8	1015..1075	CDD:290566
		leucine-rich repeat	1017..1040	CDD:275380
		leucine-rich repeat	1041..1064	CDD:275380
		LRR_RI	<1047..1244	CDD:238064	30/95 (32%)
		LRR_8	1063..1125	CDD:290566
		leucine-rich repeat	1089..1114	CDD:275380
		leucine-rich repeat	1115..1162	CDD:275380	3/9 (33%)
		LRR_8	1163..1219	CDD:290566	19/55 (35%)
		leucine-rich repeat	1163..1186	CDD:275380	8/22 (36%)
		leucine-rich repeat	1187..1210	CDD:275380	7/22 (32%)
		leucine-rich repeat	1211..1233	CDD:275380	7/21 (33%)
		leucine-rich repeat	1234..1257	CDD:275380	5/26 (19%)
		LRR_8	1235..1292	CDD:290566	15/60 (25%)
		leucine-rich repeat	1258..1279	CDD:275380	4/20 (20%)
		leucine-rich repeat	1282..1306	CDD:275380	9/26 (35%)
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	20/59 (34%)
		LRR_RI	<76..230	CDD:238064	49/160 (31%)
		leucine-rich repeat	76..99	CDD:275380	8/22 (36%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		LRR_8	122..182	CDD:290566	17/62 (27%)
		leucine-rich repeat	124..147	CDD:275380	9/25 (36%)
		leucine-rich repeat	148..171	CDD:275380	5/22 (23%)
		LRR_8	170..230	CDD:290566	20/63 (32%)
		leucine-rich repeat	172..195	CDD:275380	5/22 (23%)
		leucine-rich repeat	196..219	CDD:275380	9/26 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930