DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and IGFALS

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_001139478.1 Gene:IGFALS / 3483 HGNCID:5468 Length:643 Species:Homo sapiens


Alignment Length:768 Identity:193/768 - (25%)
Similarity:291/768 - (37%) Gaps:188/768 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 AAHPAGG-------------GPGT--GLAGGDGGGAAGIECPSFDNTACPCYKFEDGLFLECPGT 260
            |:.||||             ||.:  |...|..|.|.|..||:    ||.|...:|.        
Human    39 ASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPA----ACVCSYDDDA-------- 91

  Fly   261 TAISLRSTLERISAPIHSLSIYDFDRSVTSLSQDVFQPGVHIRHLQFSHSHLEALKDNSLRNVRS 325
                            ..||::...|::|.|...|  ||                          
Human    92 ----------------DELSVFCSSRNLTRLPDGV--PG-------------------------- 112

  Fly   326 SLESLSIVNGKLTQMPSRALSSMQKLTALDFDYNEIVRVDDYSFYGLRISKLNMKGNRLQGMPEH 390
            ..::|.:....|:.:|..|   .|.|::|.|                    ||::|.:|..:...
Human   113 GTQALWLDGNNLSSVPPAA---FQNLSSLGF--------------------LNLQGGQLGSLEPQ 154

  Fly   391 AFAGLEECMQEIDVSENGLRTFPLMALRKLDHLRILRLSNNRIPTFYGDIQLATNNASAAAAAVG 455
            |..|||. :..:.:..|.||:..|........|..|.|||||:                :....|
Human   155 ALLGLEN-LCHLHLERNQLRSLALGTFAHTPALASLGLSNNRL----------------SRLEDG 202

  Fly   456 AFQ-LPSLIFLDLSSNQFAEIGPDCFRAFPQLKTLSFYANQIELVQPEAFKSLRELMSLDMSHNR 519
            .|: |.||..|:|..|..|.:....||....|:.|....|::..:||..|..|.||..||:|.|.
Human   203 LFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA 267

  Fly   520 IIGLDPKVFEKNKRLQTVDLSHNHIHTIG-GVFSNLPQLREVFLSENNILELPADAFTNSTNVDV 583
            :..:...||.:..|||.:.|..|.|..:. |.|..|..||.:.||.|.:..|..|.|.....:.|
Human   268 LRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 332

  Fly   584 IYLESNAIAHIDPNVFSTLVNLDHLYLRSNFIPLLPVTLFDKSTKLTSLSLDNNEIQDLEIGMFR 648
            :.|..||||.:.|..|..|..|:.|.|..|.|..|....|:...:|..|:||:|::|:::.|.|.
Human   333 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 397

  Fly   649 KLEHLREVRLHNNRIRRVRRGVFEPLPSLQELHIQKNSIEDIEPQAFHTLENMQHINLQDNQLTV 713
            .|.::..:.|..|.:|.:...||..|..|..||                                
Human   398 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH-------------------------------- 430

  Fly   714 LEDIFPDENSSLLSVQLEANYLHKVHPRTFSRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYL 778
                            ||.:.|.::.|.||:....::.::||||.|..:|........:|..|.|
Human   431 ----------------LEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDL 479

  Fly   779 SDNKIRDIEKDTFVNLLLLQFLDLSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLK 843
            :.|::..:....|..|..|::|.||.|:|.:|..|...|||....|.::.|.:||:.....|.|.
Human   480 TSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 544

  Fly   844 NLKSLDLSHNPLVQLTRDIFSNEFP-LNSLNL-GN-----CSLRKLEQHAFKSLTNLNELNLERN 901
            .|:.|.|.:|.|     ..|:.:.| |..|.| ||     |.|:.|...|           |:..
Human   545 RLRYLSLRNNSL-----RTFTPQPPGLERLWLEGNPWDCGCPLKALRDFA-----------LQNP 593

  Fly   902 QLNPADIQTL-DIPNLRRLLLSHNNFSYAGSVGIMAGMLDRLRSLQQLSMSNC 953
            ...|..:|.: :..:.:....::||.:.|....::.  || ||.|.:...:.|
Human   594 SAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVG--LD-LRDLSEAHFAPC 643

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380 0/21 (0%)
LRR_8 325..384 CDD:290566 11/58 (19%)
leucine-rich repeat 327..350 CDD:275380 4/22 (18%)
leucine-rich repeat 351..461 CDD:275380 25/110 (23%)
LRR_8 373..433 CDD:290566 18/59 (31%)
LRR_RI 397..648 CDD:238064 77/252 (31%)
leucine-rich repeat 399..422 CDD:275380 4/22 (18%)
leucine-rich repeat 462..485 CDD:275380 7/22 (32%)
LRR_8 465..520 CDD:290566 19/54 (35%)
leucine-rich repeat 486..509 CDD:275380 7/22 (32%)
LRR_8 508..567 CDD:290566 22/59 (37%)
leucine-rich repeat 510..533 CDD:275380 7/22 (32%)
LRR_RI 527..785 CDD:238064 69/258 (27%)
leucine-rich repeat 534..556 CDD:275380 8/22 (36%)
LRR_8 555..613 CDD:290566 20/57 (35%)
leucine-rich repeat 557..580 CDD:275380 8/22 (36%)
leucine-rich repeat 581..604 CDD:275380 9/22 (41%)
LRR_8 604..663 CDD:290566 18/58 (31%)
leucine-rich repeat 605..628 CDD:275380 7/22 (32%)
leucine-rich repeat 629..652 CDD:275380 9/22 (41%)
LRR_8 652..711 CDD:290566 9/58 (16%)
leucine-rich repeat 653..676 CDD:275380 6/22 (27%)
leucine-rich repeat 677..700 CDD:275380 3/22 (14%)
leucine-rich repeat 701..748 CDD:275380 6/46 (13%)
leucine-rich repeat 725..736 CDD:275378 2/10 (20%)
leucine-rich repeat 749..772 CDD:275380 6/22 (27%)
LRR_8 771..831 CDD:290566 19/59 (32%)
leucine-rich repeat 773..793 CDD:275380 5/19 (26%)
LRR_RI 804..1076 CDD:238064 41/158 (26%)
LRR_8 821..903 CDD:290566 23/88 (26%)
leucine-rich repeat 821..844 CDD:275380 6/22 (27%)
leucine-rich repeat 845..868 CDD:275380 6/22 (27%)
leucine-rich repeat 869..892 CDD:275380 9/28 (32%)
leucine-rich repeat 893..915 CDD:275380 3/22 (14%)
leucine-rich repeat 916..944 CDD:275380 6/27 (22%)
leucine-rich repeat 945..968 CDD:275380 2/9 (22%)
LRR_8 967..1027 CDD:290566
leucine-rich repeat 969..992 CDD:275380
leucine-rich repeat 993..1014 CDD:275380
LRR_8 1015..1075 CDD:290566
leucine-rich repeat 1017..1040 CDD:275380
leucine-rich repeat 1041..1064 CDD:275380
LRR_RI <1047..1244 CDD:238064
LRR_8 1063..1125 CDD:290566
leucine-rich repeat 1089..1114 CDD:275380
leucine-rich repeat 1115..1162 CDD:275380
LRR_8 1163..1219 CDD:290566
leucine-rich repeat 1163..1186 CDD:275380
leucine-rich repeat 1187..1210 CDD:275380
leucine-rich repeat 1211..1233 CDD:275380
leucine-rich repeat 1234..1257 CDD:275380
LRR_8 1235..1292 CDD:290566
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
IGFALSNP_001139478.1 LRRNT 78..116 CDD:214470 14/93 (15%)
leucine-rich repeat 95..113 CDD:275380 7/45 (16%)
leucine-rich repeat 114..137 CDD:275380 6/25 (24%)
leucine-rich repeat 138..161 CDD:275380 9/42 (21%)
LRR_8 141..196 CDD:290566 18/55 (33%)
leucine-rich repeat 162..185 CDD:275380 4/22 (18%)
LRR_8 184..244 CDD:290566 21/75 (28%)
leucine-rich repeat 186..209 CDD:275380 10/38 (26%)
leucine-rich repeat 210..233 CDD:275380 7/22 (32%)
leucine-rich repeat 234..257 CDD:275380 7/22 (32%)
LRR_8 257..316 CDD:290566 22/58 (38%)
leucine-rich repeat 258..281 CDD:275380 7/22 (32%)
leucine-rich repeat 282..305 CDD:275380 8/22 (36%)
leucine-rich repeat 306..324 CDD:275380 7/17 (41%)
LRR_8 336..388 CDD:290566 19/51 (37%)
leucine-rich repeat 354..377 CDD:275380 7/22 (32%)
LRR_8 377..433 CDD:290566 19/103 (18%)
leucine-rich repeat 378..401 CDD:275380 9/22 (41%)
leucine-rich repeat 402..423 CDD:275380 5/20 (25%)
LRR_8 425..484 CDD:290566 19/106 (18%)
leucine-rich repeat 426..447 CDD:275380 9/68 (13%)
leucine-rich repeat 450..473 CDD:275380 6/22 (27%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
LRR_8 476..532 CDD:290566 18/55 (33%)
leucine-rich repeat 498..519 CDD:275380 8/20 (40%)
leucine-rich repeat 522..543 CDD:275380 5/20 (25%)
LRR_8 524..575 CDD:290566 17/55 (31%)
leucine-rich repeat 546..565 CDD:275380 6/23 (26%)
TPKR_C2 574..618 CDD:301599 8/54 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm40882
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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