DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and Toll-4

DIOPT Version :10

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:1424 Identity:262/1424 - (18%)
Similarity:463/1424 - (32%) Gaps:552/1424 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 QRQQQGRQIEQMAMGTNAEAAAAKKHKHQTKPTDSECEGKHKHKRNRNNVAGVQQHVLRLKLELQ 152
            |:|||    :|:....|.:           .|.:|     |:..::.|:...:...| |::..::
  Fly    25 QQQQQ----QQLGWCNNKD-----------DPPNS-----HQKSKSNNDARNLNSRV-RVRARVR 68

  Fly   153 LLLCALLPTALLLGLLPLPPGAAATAMI--SSAKGSVR----ELLLTEMGGGGVGVGVGGSSGGA 211
            ::                 ||......|  |:..|::|    |:.|.|:|..|.           
  Fly    69 VV-----------------PGEMRMGDINCSNGLGNIREDYCEIYLDELGENGT----------- 105

  Fly   212 AHPAGGGPGTGLAGGDGGGAAGIECPSFD------------NTACPCYKFEDGLFLECPGT---- 260
                             ...|..|..:.|            |...|.:...: :|..|..|    
  Fly   106 -----------------CSIANNEVTTEDYQMKLVFLKLEINWTSPVFHGWN-IFKICNETDYEL 152

  Fly   261 ---TAISLRSTLE-RISAPIHSLSIYDFDRSVTSLSQDVFQPGVHIRHLQFSHSH---------- 311
               :.:.:||.:: |||..:..||:... |.::  ..|::.|.|.|..:...|::          
  Fly   153 VIISVLGIRSEVDMRISPAVQYLSLLGI-REIS--GYDIYLPSVLITEMDVHHANGPKMVTFKYL 214

  Fly   312 -----LEALKDNSLRNVRSSLESLS----------------------------IVNG-KLTQMPS 342
                 ...:.:|.:|...::.|.:.                            |.|| |:..:.:
  Fly   215 YDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIFNGLKIKGLTN 279

  Fly   343 RALSSMQKLTALDFDYNEIVRVDDYSFYGLRISKLNMKGNRLQGMPEHAFAGLEECMQEIDVSEN 407
            ....::..|..|.||.   |.:.|.||  ||.|.|.              :.|..|:.::|    
  Fly   280 NTFENLTSLNTLIFDN---VFLKDLSF--LRSSTLQ--------------SSLTYCIMKVD---- 321

  Fly   408 GLRTFPLMALRKLDHLRILRLSNNR-IPTFYGDI----------QLATN------------NASA 449
              ....|.:..|..:|.|:.:|..: ...|...|          .|..|            |...
  Fly   322 --NMVDLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTLGINEVACPLKCNCSYNRDK 384

  Fly   450 AAAAVGAFQ-----LPSL-------IFLDLSSNQFAEIGPDCFRAFPQLKTLSFYANQIELVQ-- 500
            :...:..:|     :|||       ..|...||..||:..:....:..||:|....||:..:.  
  Fly   385 SQLEIDCWQKNLTTIPSLPVPKKGSSALVFQSNLLAELPDNSLEGYHNLKSLDVSYNQLTSLSVS 449

  Fly   501 --PEAFKSLRELMSLDMSHNRIIGLDPKVFEKNKRLQTVDLSHNHIHTIGGVFSNLPQLREVFLS 563
              ||:      |..||:.||:|..|.|:|.|   .|.:|:: .|.......::.:...|:|.|..
  Fly   450 QLPES------LHYLDIRHNKITTLSPQVVE---YLYSVNV-FNQYGNKWSIYCDEYHLQEFFWY 504

  Fly   564 ENNILELPADAFTN------------------STNVDVIYLESNAIAHID---PN---------- 597
            :..:|.:....|..                  ..|:|.:|||:|....||   |:          
  Fly   505 KAKLLRIKTSKFQTIMEYIELSSKGSFVENFFVQNIDQLYLEANEDEIIDAFGPSDKYFNLKLME 569

  Fly   598 -------VFS-----------------------------TLVNLDHLYLRSNFIPLLPVTLFDKS 626
                   :||                             .|:|..:|.|  :..|.||.::..| 
  Fly   570 ALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHTGEFLINCRNLSL--DIYPRLPNSIPYK- 631

  Fly   627 TKLTSLSLDNNEIQDLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQELHIQKNSIEDIE 691
               |:|.||.|||        |||.:...:             |.....|:.:||:.:|.:.:: 
  Fly   632 ---TTLYLDRNEI--------RKLTNTESL-------------VVAGHASIHKLHMSQNLLREL- 671

  Fly   692 PQAFHTL-ENMQHINLQDNQLTVLED---IFPDENSSLLSVQLEANYLHKVHPRTFSRQQKVQIM 752
              ..|.| ||:.::::::|.|..|:|   .|.:...::..::|..|      |...:.:.|..:.
  Fly   672 --PLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIELSGN------PWECNCKAKAFLS 728

  Fly   753 WLKDNQLTRVERSFFADTPQLGRLYLSDNKIRD---IEKDTFVNLLLLQFLDLSGNQLRQLRRDY 814
            :|:.::....|       ..|.|:.::|:|..:   ...||..:..|...:|.||.:|.::.: .
  Fly   729 FLRRHEPMEYE-------TVLRRVEITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIPQ-L 785

  Fly   815 FAPLQDLEELSLARNHIE-----AIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLNL 874
            ..|......|...||.::     .:.||:     ::....|:||                     
  Fly   786 PTPTYGQTTLVFERNSLKKWPSSLLPGYS-----SVTRFYLAHN--------------------- 824

  Fly   875 GNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLDIPNLRRLLLSHNNFSYAGSVGIMAGML 939
                          .|:::::|        |..::.|||        |:||||         .:.
  Fly   825 --------------RLSDIDQL--------PDKLEYLDI--------SNNNFS---------ALD 850

  Fly   940 DRLRSLQQLSMSNCSLGQIPDLLFAKNTNLVRLDLCDNRLTQINRNIFSGLNVFKELRLCRNELS 1004
            ||:|...|..|               |::.::|.|..|..|                  ||.|..
  Fly   851 DRVRGFLQKRM---------------NSSQLQLSLFGNPWT------------------CRCEDK 882

  Fly  1005 DF--------PHIALYNLSTLESLDLARNQLASIDFFKLSGTLNLRQLILRDNKITALSGFNAVN 1061
            ||        .:||  |.|.::.:|..|                                    :
  Fly   883 DFLVFVKEQAKNIA--NASAIQCIDTGR------------------------------------S 909

  Fly  1062 LTQLDSVDLSGNLLLSLPANFLRHSINLQKVHLSNNRFLQIPSSALSDVSIPRLSWLNLTGNPIN 1126
            |.:::..|:..::|:    .:...:::|..:.||.|.|:....        |.:.|.        
  Fly   910 LIEVEETDICPSVLI----YYTSLAVSLLIIALSINVFICFRQ--------PIMIWF-------- 954

  Fly  1127 RIYTVKEERYPYLKELYICQTNLSILT------SKDFEAFQALQHL--HLVNNRITRISPGAFKS 1183
                       |..|  ||   ||:..      .|.::||.:..|.  .|:...:.|:..|..|.
  Fly   955 -----------YEHE--IC---LSLAARRELDEDKKYDAFLSFTHKDEDLIEEFVDRLENGRHKF 1003

  Fly  1184 LTNLLTLDLSVNELEMLP---KERLQGLRLLRFLNISHNTLKDLEEFSVDLLEMQTLDLSFNQLD 1245
            .......|..|.  |.:|   .:.::|.|.:..| ::.|.||.    :...||.: |.|.....|
  Fly  1004 RLCFYLRDWLVG--ESIPDCINQSVKGSRRIIIL-MTKNFLKS----TWGRLEFR-LALHATSRD 1060

  Fly  1246 RISK---------KTFRNLHGLLELFLMGNRMTVLSNDAFRFLRKL-----HVLDLRKN 1290
            |..:         :.|.:|...|..:::.|  |.|..:...|..||     |...|:::
  Fly  1061 RCKRLIVVLYPDVEHFDDLDSELRAYMVLN--TYLDRNNPNFWNKLMYSMPHASHLKRS 1117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 LRR <301..606 CDD:443914 81/454 (18%)
leucine-rich repeat 303..325 CDD:275380 3/36 (8%)
leucine-rich repeat 327..350 CDD:275380 5/51 (10%)
leucine-rich repeat 351..461 CDD:275380 26/137 (19%)
leucine-rich repeat 399..422 CDD:275380 3/22 (14%)
leucine-rich repeat 462..485 CDD:275380 6/29 (21%)
LRR 486..>736 CDD:443914 70/324 (22%)
leucine-rich repeat 486..509 CDD:275380 7/26 (27%)
leucine-rich repeat 510..533 CDD:275380 10/22 (45%)
leucine-rich repeat 534..556 CDD:275380 3/21 (14%)
leucine-rich repeat 557..580 CDD:275380 5/40 (13%)
leucine-rich repeat 581..604 CDD:275380 11/71 (15%)
leucine-rich repeat 605..628 CDD:275380 6/22 (27%)
PPP1R42 627..860 CDD:455733 50/244 (20%)
leucine-rich repeat 629..652 CDD:275380 10/22 (45%)
leucine-rich repeat 653..676 CDD:275380 1/22 (5%)
leucine-rich repeat 677..700 CDD:275380 5/23 (22%)
leucine-rich repeat 701..748 CDD:275380 8/49 (16%)
leucine-rich repeat 725..736 CDD:275378 2/10 (20%)
leucine-rich repeat 749..772 CDD:275380 2/22 (9%)
leucine-rich repeat 773..793 CDD:275380 6/22 (27%)
leucine-rich repeat 821..844 CDD:275380 5/27 (19%)
leucine-rich repeat 845..868 CDD:275380 3/22 (14%)
LRR 869..1226 CDD:443914 66/375 (18%)
leucine-rich repeat 869..892 CDD:275380 1/22 (5%)
leucine-rich repeat 893..915 CDD:275380 5/21 (24%)
leucine-rich repeat 916..944 CDD:275380 7/27 (26%)
leucine-rich repeat 945..968 CDD:275380 3/22 (14%)
leucine-rich repeat 969..992 CDD:275380 4/22 (18%)
leucine-rich repeat 993..1014 CDD:275380 7/28 (25%)
leucine-rich repeat 1017..1040 CDD:275380 2/22 (9%)
leucine-rich repeat 1041..1064 CDD:275380 1/22 (5%)
leucine-rich repeat 1089..1114 CDD:275380 5/24 (21%)
leucine-rich repeat 1115..1162 CDD:275380 10/52 (19%)
PPP1R42 1155..1317 CDD:455733 35/155 (23%)
leucine-rich repeat 1163..1186 CDD:275380 5/24 (21%)
leucine-rich repeat 1187..1210 CDD:275380 5/25 (20%)
leucine-rich repeat 1211..1233 CDD:275380 4/21 (19%)
leucine-rich repeat 1234..1257 CDD:275380 6/31 (19%)
leucine-rich repeat 1258..1279 CDD:275380 4/20 (20%)
leucine-rich repeat 1282..1306 CDD:275380 3/14 (21%)
Toll-4NP_523519.2 LRR 210..>470 CDD:443914 55/290 (19%)
leucine-rich repeat 264..287 CDD:275380 4/22 (18%)
leucine-rich repeat 288..308 CDD:275380 10/24 (42%)
leucine-rich repeat 309..334 CDD:275380 6/44 (14%)
leucine-rich repeat 335..386 CDD:275380 8/50 (16%)
PRK15370 <381..>482 CDD:185268 29/110 (26%)
leucine-rich repeat 388..408 CDD:275380 4/19 (21%)
leucine-rich repeat 412..432 CDD:275378 5/19 (26%)
LRR <416..591 CDD:443914 40/184 (22%)
leucine-rich repeat 433..454 CDD:275378 6/20 (30%)
leucine-rich repeat 455..478 CDD:275378 11/25 (44%)
leucine-rich repeat 479..490 CDD:275378 2/11 (18%)
leucine-rich repeat 632..657 CDD:275378 11/45 (24%)
leucine-rich repeat 658..679 CDD:275378 5/23 (22%)
leucine-rich repeat 680..706 CDD:275378 5/25 (20%)
PCC 684..>771 CDD:188093 18/99 (18%)
leucine-rich repeat 707..719 CDD:275378 3/17 (18%)
leucine-rich repeat 771..791 CDD:275380 5/20 (25%)
PRK15370 <793..>877 CDD:185268 29/181 (16%)
leucine-rich repeat 793..815 CDD:275378 5/26 (19%)
leucine-rich repeat 816..835 CDD:275378 6/61 (10%)
leucine-rich repeat 836..859 CDD:275378 11/39 (28%)
TIR 974..1110 CDD:214587 32/145 (22%)

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