DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and kek5

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_001245746.1	Gene:	kek5 / 32930	FlyBaseID:	FBgn0031016	Length:	931	Species:	Drosophila melanogaster

Alignment Length:	259	Identity:	69/259 - (26%)
Similarity:	116/259 - (44%)	Gaps:	36/259 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   722 NSSLLSVQLEANYLHKVHPRTFSRQQKVQIMWLKDNQLTRVERSFF--ADTPQLGRLYLSDNKIR 784
            ||...|...:...|.|: |:..|.:  :|::....||:..:.|..|  |..|.:.:::|.:..|:
  Fly    51 NSGKKSADCKNKALTKI-PQDMSNE--MQVLDFAHNQIPELRREEFLLAGLPNVHKIFLRNCTIQ 112

  Fly   785 DIEKDTFVNLLLLQFLDLSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLD 849
            ::.::.|..|.:|..||||||::|:|....||.|:.|..:.:..|.||.:..:.|..|..|..::
  Fly   113 EVHREAFKGLHILIELDLSGNRIRELHPGTFAGLEKLRNVIINNNEIEVLPNHLFVNLSFLSRIE 177

  Fly   850 LSHNPLVQLTRDIFSNEFPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLERNQLN---------- 904
            ..:|.|.|:...:|:....|::::|....|..|.:..||.|..|..|:|:.|..|
  Fly   178 FRNNRLRQVQLHVFAGTMALSAISLEQNRLSHLHKETFKDLQKLMHLSLQGNAWNCSCELQDFRD 242

  Fly   905 ----------PADIQTLDIPNLRRLLLSH---NNFSYAGSVGIMAGMLDRLRSLQQLSMSNCSL 955
                      |.|.|  :.|.||..|.|.   .||:....:      |..:||..:.:..|.||
  Fly   243 FAISKRLYTPPTDCQ--EPPQLRGKLWSEVPSENFACRPRI------LGSVRSFIEANHDNISL 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064	16/64 (25%)
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		LRR_8	604..663	CDD:290566
		leucine-rich repeat	605..628	CDD:275380
		leucine-rich repeat	629..652	CDD:275380
		LRR_8	652..711	CDD:290566
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380	7/25 (28%)
		leucine-rich repeat	725..736	CDD:275378	1/10 (10%)
		leucine-rich repeat	749..772	CDD:275380	6/24 (25%)
		LRR_8	771..831	CDD:290566	19/59 (32%)
		leucine-rich repeat	773..793	CDD:275380	3/19 (16%)
		LRR_RI	804..1076	CDD:238064	46/175 (26%)
		LRR_8	821..903	CDD:290566	22/81 (27%)
		leucine-rich repeat	821..844	CDD:275380	6/22 (27%)
		leucine-rich repeat	845..868	CDD:275380	5/22 (23%)
		leucine-rich repeat	869..892	CDD:275380	7/22 (32%)
		leucine-rich repeat	893..915	CDD:275380	8/41 (20%)
		leucine-rich repeat	916..944	CDD:275380	7/30 (23%)
		leucine-rich repeat	945..968	CDD:275380	3/11 (27%)
		LRR_8	967..1027	CDD:290566
		leucine-rich repeat	969..992	CDD:275380
		leucine-rich repeat	993..1014	CDD:275380
		LRR_8	1015..1075	CDD:290566
		leucine-rich repeat	1017..1040	CDD:275380
		leucine-rich repeat	1041..1064	CDD:275380
		LRR_RI	<1047..1244	CDD:238064
		LRR_8	1063..1125	CDD:290566
		leucine-rich repeat	1089..1114	CDD:275380
		leucine-rich repeat	1115..1162	CDD:275380
		LRR_8	1163..1219	CDD:290566
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
kek5	NP_001245746.1	LRR_RI	<76..160	CDD:238064	25/83 (30%)
		leucine-rich repeat	76..100	CDD:275380	6/23 (26%)
		LRR_8	99..159	CDD:290566	19/59 (32%)
		leucine-rich repeat	101..124	CDD:275380	4/22 (18%)
		LRR	122..145	CDD:197688	11/22 (50%)
		leucine-rich repeat	125..148	CDD:275380	12/22 (55%)
		LRR_8	148..207	CDD:290566	13/58 (22%)
		leucine-rich repeat	149..172	CDD:275380	6/22 (27%)
		leucine-rich repeat	173..196	CDD:275380	5/22 (23%)
		LRR_8	197..>229	CDD:290566	10/31 (32%)
		leucine-rich repeat	197..220	CDD:275380	7/22 (32%)
		LRRCT	229..277	CDD:214507	12/49 (24%)
		Ig	296..376	CDD:143165	2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453694
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840