DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and Lrrc8d

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_001008339.2 Gene:Lrrc8d / 305131 RGDID:1309601 Length:860 Species:Rattus norvegicus


Alignment Length:955 Identity:191/955 - (20%)
Similarity:333/955 - (34%) Gaps:346/955 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 FPLMALRKLDHLRILRLSNNRIPTFYGDIQLATNNASAAAAAVGAFQLPSLIFLDLSSNQFAEIG 476
            ||.:|   |.|..||.:|:|    |:                   |:.|...   .....|..|.
  Rat   167 FPYLA---LIHTIILMVSSN----FW-------------------FKYPKTC---SKVEHFVSIL 202

  Fly   477 PDCFRAFPQLKTLSFYANQIELVQPEAFKSLRELMSLDMSHNRIIGLDPKVFEKNKRLQTVDLSH 541
            ..||.:                  |...|:|.|....|...|:            :|:.......
  Rat   203 GKCFES------------------PWTTKALSETACEDSEENK------------QRITGAQTLP 237

  Fly   542 NHIHTI---GGVFSNLPQLREV---FLSENNILELPADAFTNSTNVDVIYLESNAIAHIDPNVFS 600
            .|:.|.   |...::.|.:.:.   |.:|..::|:|:                            
  Rat   238 KHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPS---------------------------- 274

  Fly   601 TLVNLDHLYLRSNFIPLLPVTLFDKSTKLTSLSLDNNEIQDLEIGMFRKLEHLREVRLHNNRIRR 665
                               :|:.||.        |..:.:.|       .|.:|:.|.|      
  Rat   275 -------------------MTILDKK--------DGEQAKAL-------FEKVRKFRAH------ 299

  Fly   666 VRRGVFEPLPSLQELHIQKNSIEDIE-------PQAFHTLENMQHI-NLQDNQLTVLEDIFPDEN 722
                 .|....:.:|::.:..|:..:       ...|....:.:|: ..:...||..|......|
  Rat   300 -----VEDSDLIYKLYVVQTLIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHN 359

  Fly   723 SSLLSVQLEANYLHKVHPRTFSRQQKVQIMW-----LKDNQLTRV-ERSFFADTP---------- 771
            .:.:..:|..:|:..:....|.  ....:.|     ||:....:| |.|.|:|.|          
  Rat   360 MAYMLKKLLISYISIICVYGFI--CLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL 422

  Fly   772 ----QLGRLY----------LSDNKIRDIEKD---TFVNLLLLQFLDLSGNQLRQLRRDYFAPLQ 819
                |..:||          :|:||:|:|..:   ||                .:||:......|
  Rat   423 HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTF----------------EKLRQHVSRNAQ 471

  Fly   820 DLEELSLARNHIEAIEGY--AFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLNLGNCSLRKL 882
            |.:||     |:..:.|.  |...|.:|..|.|...|..::...| |....|..|:|.:|. .|:
  Rat   472 DKQEL-----HLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKI-SQMTNLQELHLCHCP-AKV 529

  Fly   883 EQHAFKSLTNLNELNLERNQLNPADIQTLDI----------PNLRRLLL-----SHNNFSYAGSV 932
            ||.||..|         |:.|....::..|:          .|||.|.|     |.||       
  Rat   530 EQTAFSFL---------RDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENN------- 578

  Fly   933 GIMAGMLDRLRSLQQLSMSN--CSLGQIPDLLFAKNTNLVRLDLCDN--RLTQINRNIFSGLNVF 993
             .|.| |:.||.|:.|.:.:  .:|.::|..:.....:|.:|.:.::  :|..:| ::...:|| 
  Rat   579 -KMIG-LESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLN-SLKKMMNV- 639

  Fly   994 KELRLCRNELSDFPHIALYNLSTLESLDLARNQLASIDFFKLSGTLNLRQLILRDNKITALSGFN 1058
            .||.|...||...|| |:::||.|:.|||..|.:.:|:           ::|            :
  Rat   640 AELELQNCELERIPH-AIFSLSNLQELDLKSNSIRTIE-----------EII------------S 680

  Fly  1059 AVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVHLSNNRFLQIPSSALSDVSIPRLSWLNLTGN 1123
            ..:|.:|..:.|..|.::::|.: :.|..||:.::.|||:...:|.:..   |:.:|..|:::.|
  Rat   681 FQHLKRLTCLKLWHNKIVAIPPS-ITHVKNLESLYFSNNKLESLPVAVF---SLQKLRCLDVSYN 741

  Fly  1124 PINRIYTVKEERYPYLKELYICQTNLSILTSKDFEAFQALQHLHLVNNRITRISPGAFKSLTNLL 1188
            .|:.|                 ...:.:|        |.|||||:..|::               
  Rat   742 NISTI-----------------PIEIGLL--------QNLQHLHITGNKV--------------- 766

  Fly  1189 TLDLSVNELEMLPKERLQGLRLLRFLNISHNTLKDLEEFSVDLLEMQTLDLSFNQLDRISKKTFR 1253
                     ::|||:..:.:: ||.||:..|.:..|.|....|.::..|:|..|.|||:..:   
  Rat   767 ---------DVLPKQLFKCVK-LRTLNLGQNCIASLPEKISQLSQLTQLELKGNCLDRLPAQ--- 818

  Fly  1254 NLHGLLELFLMGNRMTVLSNDAFRFLRKLHVLDLRKNYFELVPLE 1298
                      :|.         .|.|:|..:: :....|:.:|||
  Rat   819 ----------LGQ---------CRMLKKSGLV-VEDQLFDTLPLE 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380
LRR_8 325..384 CDD:290566
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380 11/48 (23%)
LRR_8 373..433 CDD:290566 9/20 (45%)
LRR_RI 397..648 CDD:238064 36/241 (15%)
leucine-rich repeat 399..422 CDD:275380 4/9 (44%)
leucine-rich repeat 462..485 CDD:275380 4/22 (18%)
LRR_8 465..520 CDD:290566 10/54 (19%)
leucine-rich repeat 486..509 CDD:275380 3/22 (14%)
LRR_8 508..567 CDD:290566 10/64 (16%)
leucine-rich repeat 510..533 CDD:275380 2/22 (9%)
LRR_RI 527..785 CDD:238064 45/301 (15%)
leucine-rich repeat 534..556 CDD:275380 3/24 (13%)
LRR_8 555..613 CDD:290566 5/60 (8%)
leucine-rich repeat 557..580 CDD:275380 4/25 (16%)
leucine-rich repeat 581..604 CDD:275380 0/22 (0%)
LRR_8 604..663 CDD:290566 9/58 (16%)
leucine-rich repeat 605..628 CDD:275380 3/22 (14%)
leucine-rich repeat 629..652 CDD:275380 2/22 (9%)
LRR_8 652..711 CDD:290566 8/66 (12%)
leucine-rich repeat 653..676 CDD:275380 4/22 (18%)
leucine-rich repeat 677..700 CDD:275380 3/29 (10%)
leucine-rich repeat 701..748 CDD:275380 8/47 (17%)
leucine-rich repeat 725..736 CDD:275378 2/10 (20%)
leucine-rich repeat 749..772 CDD:275380 9/42 (21%)
LRR_8 771..831 CDD:290566 17/86 (20%)
leucine-rich repeat 773..793 CDD:275380 9/32 (28%)
LRR_RI 804..1076 CDD:238064 73/292 (25%)
LRR_8 821..903 CDD:290566 23/83 (28%)
leucine-rich repeat 821..844 CDD:275380 6/24 (25%)
leucine-rich repeat 845..868 CDD:275380 6/22 (27%)
leucine-rich repeat 869..892 CDD:275380 10/22 (45%)
leucine-rich repeat 893..915 CDD:275380 3/31 (10%)
leucine-rich repeat 916..944 CDD:275380 11/32 (34%)
leucine-rich repeat 945..968 CDD:275380 4/24 (17%)
LRR_8 967..1027 CDD:290566 21/61 (34%)
leucine-rich repeat 969..992 CDD:275380 4/24 (17%)
leucine-rich repeat 993..1014 CDD:275380 8/20 (40%)
LRR_8 1015..1075 CDD:290566 12/59 (20%)
leucine-rich repeat 1017..1040 CDD:275380 6/22 (27%)
leucine-rich repeat 1041..1064 CDD:275380 2/22 (9%)
LRR_RI <1047..1244 CDD:238064 40/196 (20%)
LRR_8 1063..1125 CDD:290566 15/61 (25%)
leucine-rich repeat 1089..1114 CDD:275380 6/24 (25%)
leucine-rich repeat 1115..1162 CDD:275380 6/46 (13%)
LRR_8 1163..1219 CDD:290566 13/55 (24%)
leucine-rich repeat 1163..1186 CDD:275380 6/22 (27%)
leucine-rich repeat 1187..1210 CDD:275380 3/22 (14%)
leucine-rich repeat 1211..1233 CDD:275380 8/21 (38%)
leucine-rich repeat 1234..1257 CDD:275380 6/22 (27%)
LRR_8 1235..1292 CDD:290566 10/56 (18%)
leucine-rich repeat 1258..1279 CDD:275380 2/20 (10%)
leucine-rich repeat 1282..1306 CDD:275380 4/17 (24%)
Lrrc8dNP_001008339.2 Pannexin_like 3..386 CDD:289311 52/352 (15%)
leucine-rich repeat 517..538 CDD:275378 10/30 (33%)
LRR_RI 557..834 CDD:238064 87/388 (22%)
leucine-rich repeat 564..591 CDD:275380 13/35 (37%)
leucine-rich repeat 592..617 CDD:275380 4/24 (17%)
LRR_8 638..697 CDD:290566 23/83 (28%)
leucine-rich repeat 639..661 CDD:275380 10/23 (43%)
leucine-rich repeat 662..686 CDD:275380 8/46 (17%)
LRR_8 685..743 CDD:290566 15/61 (25%)
leucine-rich repeat 687..709 CDD:275380 5/22 (23%)
leucine-rich repeat 710..732 CDD:275380 6/24 (25%)
leucine-rich repeat 733..755 CDD:275380 6/46 (13%)
LRR_8 755..810 CDD:290566 19/79 (24%)
leucine-rich repeat 756..778 CDD:275380 9/45 (20%)
leucine-rich repeat 779..801 CDD:275380 8/21 (38%)
leucine-rich repeat 802..822 CDD:275380 7/41 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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