DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and Lrrc8e

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_001029311.1 Gene:Lrrc8e / 304203 RGDID:1311979 Length:795 Species:Rattus norvegicus


Alignment Length:496 Identity:124/496 - (25%)
Similarity:202/496 - (40%) Gaps:146/496 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   880 RKLEQHAFKSLTNLNELNLERNQLNPADIQTLDIPNLRRLLLSHNNFSYAGSVGIMAGMLDRLRS 944
            |.|::::|:|:.....:|              |||::|      |:|::      |..::|:.  
  Rat   336 RPLKEYSFRSVREETGMN--------------DIPDVR------NDFAF------MLHLIDQY-- 372

  Fly   945 LQQLSMSNCSLGQIPDLLFAKNTNLVRLDLCDNRLTQIN---------------RNIFSGLNVFK 994
                           |.|::|...:...::.::||.|:|               ||....|    
  Rat   373 ---------------DSLYSKRFAVFLSEVSESRLKQLNLNHEWTPDKLRQKLQRNARGRL---- 418

  Fly   995 ELRLCRNELSDFPHIALYNLSTLESLDLARNQLASIDFFK-LSGTLNLR---------------Q 1043
            ||.||.  |...|. .::.||.:|:|.|  ..:..|.|.. ||..:||:               |
  Rat   419 ELSLCM--LPGLPD-TVFELSEVEALRL--EAICDISFPPGLSQLVNLQELSLLHSPARLPFSSQ 478

  Fly  1044 LILRDNK----------------ITALSGFNAVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKV 1092
            :.|||..                :..|.|...::|..|...:::....|    ..||....|:.:
  Rat   479 IFLRDRLKVICVKFEELREVPLWVFGLRGLEELHLEGLFPPEMARGATL----ESLRELKQLKVL 539

  Fly  1093 HLSNNRFLQIPSSALSDVS--IPRLSWLN-----LTGNPINRIYTVKE--------ERYPY---- 1138
            .|.:|.. ::|:| ::||:  :.|||..|     |..|.:.::..::|        ||.|:    
  Rat   540 SLRSNAG-KVPAS-VTDVAGHLQRLSLHNDGARLLALNSLKKLAVLRELELVACGLERIPHAIFS 602

  Fly  1139 ---LKELYICQTNLSILTSKDFEAFQALQH------LHLVNNRITRISPGAFKSLTNLLTLDLSV 1194
               |:||.:...:|     :..|...:.||      |.|.:|:|..: |...:.|.:|..|.||.
  Rat   603 LGALQELDLKDNHL-----RSIEEILSFQHCRKLVILRLWHNQIAYV-PEHVRKLRSLEQLYLSH 661

  Fly  1195 NELEMLPKERLQ--GLRLLRFLNISHNTLKDLEEFSVDLLEMQTLDLSFNQLDRISKKTFRNLHG 1257
            |:||.||.:..|  ||||   |::|||.|:.|......|..:|.|.||:|.|:.:..:.| ..|.
  Rat   662 NKLETLPAQLGQCFGLRL---LDVSHNGLRSLPPELGLLQSLQHLALSYNALESLPDELF-FCHK 722

  Fly  1258 LLELFLMGNRMTVLSNDAFRFLRKLHVLDLRKNYFELVPLE 1298
            |..|.|..|.:|..|... ..|:.|..|:|:.|..|.:|.|
  Rat   723 LRTLLLGYNHLTQFSPHV-AALQALSRLELKGNRLEALPEE 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380
LRR_8 325..384 CDD:290566
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380
LRR_8 373..433 CDD:290566
LRR_RI 397..648 CDD:238064
leucine-rich repeat 399..422 CDD:275380
leucine-rich repeat 462..485 CDD:275380
LRR_8 465..520 CDD:290566
leucine-rich repeat 486..509 CDD:275380
LRR_8 508..567 CDD:290566
leucine-rich repeat 510..533 CDD:275380
LRR_RI 527..785 CDD:238064
leucine-rich repeat 534..556 CDD:275380
LRR_8 555..613 CDD:290566
leucine-rich repeat 557..580 CDD:275380
leucine-rich repeat 581..604 CDD:275380
LRR_8 604..663 CDD:290566
leucine-rich repeat 605..628 CDD:275380
leucine-rich repeat 629..652 CDD:275380
LRR_8 652..711 CDD:290566
leucine-rich repeat 653..676 CDD:275380
leucine-rich repeat 677..700 CDD:275380
leucine-rich repeat 701..748 CDD:275380
leucine-rich repeat 725..736 CDD:275378
leucine-rich repeat 749..772 CDD:275380
LRR_8 771..831 CDD:290566
leucine-rich repeat 773..793 CDD:275380
LRR_RI 804..1076 CDD:238064 48/242 (20%)
LRR_8 821..903 CDD:290566 5/22 (23%)
leucine-rich repeat 821..844 CDD:275380
leucine-rich repeat 845..868 CDD:275380
leucine-rich repeat 869..892 CDD:275380 4/11 (36%)
leucine-rich repeat 893..915 CDD:275380 3/21 (14%)
leucine-rich repeat 916..944 CDD:275380 5/27 (19%)
leucine-rich repeat 945..968 CDD:275380 3/22 (14%)
LRR_8 967..1027 CDD:290566 18/74 (24%)
leucine-rich repeat 969..992 CDD:275380 7/37 (19%)
leucine-rich repeat 993..1014 CDD:275380 6/20 (30%)
LRR_8 1015..1075 CDD:290566 18/91 (20%)
leucine-rich repeat 1017..1040 CDD:275380 7/23 (30%)
leucine-rich repeat 1041..1064 CDD:275380 8/53 (15%)
LRR_RI <1047..1244 CDD:238064 65/242 (27%)
LRR_8 1063..1125 CDD:290566 17/68 (25%)
leucine-rich repeat 1089..1114 CDD:275380 7/26 (27%)
leucine-rich repeat 1115..1162 CDD:275380 14/66 (21%)
LRR_8 1163..1219 CDD:290566 24/63 (38%)
leucine-rich repeat 1163..1186 CDD:275380 8/28 (29%)
leucine-rich repeat 1187..1210 CDD:275380 12/24 (50%)
leucine-rich repeat 1211..1233 CDD:275380 7/21 (33%)
leucine-rich repeat 1234..1257 CDD:275380 7/22 (32%)
LRR_8 1235..1292 CDD:290566 19/56 (34%)
leucine-rich repeat 1258..1279 CDD:275380 6/20 (30%)
leucine-rich repeat 1282..1306 CDD:275380 7/17 (41%)
Lrrc8eNP_001029311.1 Pannexin_like 1..330 CDD:289311
leucine-rich repeat 508..532 CDD:275380 4/27 (15%)
LRR_RI 526..790 CDD:238064 76/254 (30%)
LRR 1 535..556 6/22 (27%)
leucine-rich repeat 536..558 CDD:275380 7/23 (30%)
LRR 2 558..578 6/19 (32%)
leucine-rich repeat 559..582 CDD:275380 6/22 (27%)
LRR 3 582..603 4/20 (20%)
LRR_8 583..641 CDD:290566 14/62 (23%)
leucine-rich repeat 583..605 CDD:275380 4/21 (19%)
LRR 4 605..626 5/25 (20%)
leucine-rich repeat 606..630 CDD:275380 7/28 (25%)
LRR_8 629..687 CDD:290566 24/61 (39%)
LRR 5 630..651 5/21 (24%)
leucine-rich repeat 631..653 CDD:275380 6/22 (27%)
LRR 6 653..674 9/20 (45%)
leucine-rich repeat 654..676 CDD:275380 10/21 (48%)
LRR_8 676..733 CDD:290566 23/60 (38%)
LRR 7 676..697 10/23 (43%)
leucine-rich repeat 677..699 CDD:275380 10/24 (42%)
LRR 8 699..720 7/21 (33%)
leucine-rich repeat 700..722 CDD:275380 7/22 (32%)
LRR 9 722..743 6/21 (29%)
leucine-rich repeat 723..745 CDD:275380 7/22 (32%)
LRR 10 745..766 7/18 (39%)
leucine-rich repeat 746..766 CDD:275380 7/17 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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