DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and TSKU

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_001305406.1	Gene:	TSKU / 25987	HGNCID:	28850	Length:	367	Species:	Homo sapiens

Alignment Length:	259	Identity:	79/259 - (30%)
Similarity:	122/259 - (47%)	Gaps:	41/259 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   800 LDLSGNQLRQLRRDYFA--PLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDI 862
            ||||.|:|..:.....|  ....|..|.|:.|.:.:|...||::|:.|:|||||||.|..|..:.
Human    77 LDLSSNRLEMVNESVLAGPGYTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAES 141

  Fly   863 FSNEFPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLE--------------RNQLNPADIQTLD- 912
            |::. ||:.:||.:..||::...||.:.:....|:::              |..|....||:|:
Human   142 FTSS-PLSDVNLSHNQLREVSVSAFTTHSQGRALHVDLSHNLIHRLVPHPTRAGLPAPTIQSLNL 205

  Fly   913 -------IPNLRRLLLSH-----NNFSYAGSVGIMAGMLDRLRSLQQLSMSNCSLGQIPDLL--- 962
                   :||||.|.|.:     |..:..|. |..||    |..|..||::  ||.::|:|.
Human   206 AWNRLHAVPNLRDLPLRYLSLDGNPLAVIGP-GAFAG----LGGLTHLSLA--SLQRLPELAPSG 263

  Fly   963 FAKNTNLVRLDLCDN-RLTQINRNIFSGLNVFKELRLCRNELSDFPHIALYNLSTLESLDLARN 1025
            |.:...|..|||..| :|......:||||:..:||.|....|...|...|.:|..|:|:.:.::
Human   264 FRELPGLQVLDLSGNPKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLLHLPALQSVSVGQD 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		LRR_8	604..663	CDD:290566
		leucine-rich repeat	605..628	CDD:275380
		leucine-rich repeat	629..652	CDD:275380
		LRR_8	652..711	CDD:290566
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		LRR_8	771..831	CDD:290566	11/32 (34%)
		leucine-rich repeat	773..793	CDD:275380
		LRR_RI	804..1076	CDD:238064	75/255 (29%)
		LRR_8	821..903	CDD:290566	29/95 (31%)
		leucine-rich repeat	821..844	CDD:275380	8/22 (36%)
		leucine-rich repeat	845..868	CDD:275380	11/22 (50%)
		leucine-rich repeat	869..892	CDD:275380	7/22 (32%)
		leucine-rich repeat	893..915	CDD:275380	6/43 (14%)
		leucine-rich repeat	916..944	CDD:275380	10/32 (31%)
		leucine-rich repeat	945..968	CDD:275380	8/25 (32%)
		LRR_8	967..1027	CDD:290566	19/60 (32%)
		leucine-rich repeat	969..992	CDD:275380	10/23 (43%)
		leucine-rich repeat	993..1014	CDD:275380	6/20 (30%)
		LRR_8	1015..1075	CDD:290566	2/11 (18%)
		leucine-rich repeat	1017..1040	CDD:275380	2/9 (22%)
		leucine-rich repeat	1041..1064	CDD:275380
		LRR_RI	<1047..1244	CDD:238064
		LRR_8	1063..1125	CDD:290566
		leucine-rich repeat	1089..1114	CDD:275380
		leucine-rich repeat	1115..1162	CDD:275380
		LRR_8	1163..1219	CDD:290566
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
TSKU	NP_001305406.1	LRR_RI	52..305	CDD:238064	73/235 (31%)
		leucine-rich repeat	76..99	CDD:275380	7/21 (33%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR_8	103..157	CDD:290566	22/54 (41%)
		leucine-rich repeat	124..145	CDD:275380	11/20 (55%)
		leucine-rich repeat	147..170	CDD:275380	7/22 (32%)
		leucine-rich repeat	171..197	CDD:275380	3/25 (12%)
		leucine-rich repeat	200..219	CDD:275380	7/18 (39%)
		LRR_8	221..279	CDD:290566	19/64 (30%)
		leucine-rich repeat	221..244	CDD:275380	7/27 (26%)
		leucine-rich repeat	245..269	CDD:275380	8/25 (32%)
		LRR_8	268..321	CDD:290566	18/52 (35%)
		leucine-rich repeat	270..294	CDD:275380	10/23 (43%)
		leucine-rich repeat	295..316	CDD:275380	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010