DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and Lrrc8d

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_001116240.1 Gene:Lrrc8d / 231549 MGIID:1922368 Length:859 Species:Mus musculus


Alignment Length:1115 Identity:213/1115 - (19%)
Similarity:381/1115 - (34%) Gaps:416/1115 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   258 PGTTAISLRSTLERISAPIHSLSIYDFDRSVTSLSQDV------FQPGVHIRHLQFSHSHLEALK 316
            ||...|:  :.:.|:....|.      |::..:.:.||      ..|.:   .||.:|.|.|   
Mouse    70 PGNADIT--TEVPRMETATHQ------DQNGQTTTNDVAFGTSAVTPDI---PLQATHPHAE--- 120

  Fly   317 DNSLRNVRSSLESLSIVNGKLTQMPSRALSSMQKLTALDFDYNEIVRVDDYSFYGLRISKLNMKG 381
             ::|.|..:..|... ..|:.|.:                |:.:.|.::...::           
Mouse   121 -STLPNQEAKKEKRD-PTGRKTNL----------------DFQQYVFINQMCYH----------- 156

  Fly   382 NRLQGMPEHAFAGLEECMQEIDVSENGLRTFPLMALRKLDHLRILRLSNNRIPTFYGDIQLATNN 446
               ..:|.::                  :.||.:|   |.|..||.:|:|    |:         
Mouse   157 ---LALPWYS------------------KYFPYLA---LIHTIILMVSSN----FW--------- 184

  Fly   447 ASAAAAAVGAFQLPSLIFLDLSSNQFAEIGPDCFRAFPQLKTLSFYANQIELVQPEAFKSLRELM 511
                      |:.|...   .....|..|...||.:                  |...|:|.|..
Mouse   185 ----------FKYPKTC---SKVEHFVSILGKCFES------------------PWTTKALSETA 218

  Fly   512 SLDMSHNRIIGLDPKVFEKNKRLQTVDLSHNHIHTI---GGVFSNLPQLREV---FLSENNILEL 570
            ..|...|:            :|:........|:.|.   |...::.|.:.:.   |.:|..::|:
Mouse   219 CEDSEENK------------QRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEV 271

  Fly   571 PADAFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRSNFIPLLPVTLFDKSTKLTSLSLD 635
            |:                                               :|:.||.        |
Mouse   272 PS-----------------------------------------------MTILDKK--------D 281

  Fly   636 NNEIQDLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQELHIQKNSIEDIE-------PQ 693
            ..:.:.|       .|.:|:.|.|           .|....:.:|::.:..|:..:       ..
Mouse   282 GEQAKAL-------FEKVRKFRAH-----------VEDSDLIYKLYVVQTLIKTAKFIFILCYTA 328

  Fly   694 AFHTLENMQHI-NLQDNQLTVLEDIFPDENSSLLSVQLEANYLHKVHPRTFSRQQKVQIMW---- 753
            .|....:.:|: ..:...||..|......|.:.:..:|..:|:..:....|.  ....:.|    
Mouse   329 NFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFI--CLYTLFWLFRI 391

  Fly   754 -LKDNQLTRV-ERSFFADTP--------------QLGRLY----------LSDNKIRDIEKD--- 789
             ||:....:| |.|.|:|.|              |..:||          :|:||:|:|..:   
Mouse   392 PLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEW 456

  Fly   790 TFVNLLLLQFLDLSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGY--AFAKLKNLKSLDLSH 852
            ||                .:||:......||.:||     |:..:.|.  |...|.:|..|.|..
Mouse   457 TF----------------EKLRQHVSRNAQDKQEL-----HLFMLSGVPDAVFDLTDLDVLKLEL 500

  Fly   853 NPLVQLTRDIFSNEFPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLDI---- 913
            .|..::...| |....|..|:|.:|. .|:||.||..|         |:.|....::..|:    
Mouse   501 IPEAKIPAKI-SQMTNLQELHLCHCP-AKVEQTAFSFL---------RDHLRCLHVKFTDVAEIP 554

  Fly   914 ------PNLRRLLL-----SHNNFSYAGSVGIMAGMLDRLRSLQQLSMSN--CSLGQIPDLLFAK 965
                  .|||.|.|     |.||        .|.| |:.||.|:.|.:.:  .:|.::|..:...
Mouse   555 AWVYLLKNLRELYLIGNLNSENN--------KMIG-LESLRELRHLKILHVKSNLTKVPSNITDV 610

  Fly   966 NTNLVRLDLCDN--RLTQINRNIFSGLNVFKELRLCRNELSDFPHIALYNLSTLESLDLARNQLA 1028
            ..:|.:|.:.::  :|..:| ::...:|| .||.|...||...|| |:::||.|:.|||..|.:.
Mouse   611 APHLTKLVIHNDGTKLLVLN-SLKKMMNV-AELELQNCELERIPH-AIFSLSNLQELDLKSNNIR 672

  Fly  1029 SIDFFKLSGTLNLRQLILRDNKITALSGFNAVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVH 1093
            :|:           ::|            :..:|.:|..:.|..|.::::|.: :.|..||:.::
Mouse   673 TIE-----------EII------------SFQHLKRLTCLKLWHNKIVAIPPS-ITHVKNLESLY 713

  Fly  1094 LSNNRFLQIPSSALSDVSIPRLSWLNLTGNPINRIYTVKEERYPYLKELYICQTNLSILTSKDFE 1158
            .|||:...:|::..   |:.:|..|:::.|.|:.|                 ...:.:|      
Mouse   714 FSNNKLESLPTAVF---SLQKLRCLDVSYNNISTI-----------------PIEIGLL------ 752

  Fly  1159 AFQALQHLHLVNNRITRISPGAFKSLTNLLTLDLSVNELEMLPKERLQGLRLLRFLNISHNTLKD 1223
              |.|||||:..|::                        ::|||:..:.:: ||.||:..|.:..
Mouse   753 --QNLQHLHITGNKV------------------------DILPKQLFKCVK-LRTLNLGQNCIAS 790

  Fly  1224 LEEFSVDLLEMQTLDLSFNQLDRISKKTFRNLHGLLELFLMGNRMTVLSNDAFRFLRKLHVLDLR 1288
            |.|....|.::..|:|..|.|||:..:             :|.         .|.|:|..:: :.
Mouse   791 LPEKISQLTQLTQLELKGNCLDRLPAQ-------------LGQ---------CRMLKKSGLV-VE 832

  Fly  1289 KNYFELVPLE 1298
            ...|:.:|||
Mouse   833 DQLFDTLPLE 842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380 7/21 (33%)
LRR_8 325..384 CDD:290566 5/58 (9%)
leucine-rich repeat 327..350 CDD:275380 3/22 (14%)
leucine-rich repeat 351..461 CDD:275380 14/109 (13%)
LRR_8 373..433 CDD:290566 10/59 (17%)
LRR_RI 397..648 CDD:238064 36/256 (14%)
leucine-rich repeat 399..422 CDD:275380 4/22 (18%)
leucine-rich repeat 462..485 CDD:275380 4/22 (18%)
LRR_8 465..520 CDD:290566 10/54 (19%)
leucine-rich repeat 486..509 CDD:275380 3/22 (14%)
LRR_8 508..567 CDD:290566 10/64 (16%)
leucine-rich repeat 510..533 CDD:275380 2/22 (9%)
LRR_RI 527..785 CDD:238064 45/301 (15%)
leucine-rich repeat 534..556 CDD:275380 3/24 (13%)
LRR_8 555..613 CDD:290566 5/60 (8%)
leucine-rich repeat 557..580 CDD:275380 4/25 (16%)
leucine-rich repeat 581..604 CDD:275380 0/22 (0%)
LRR_8 604..663 CDD:290566 9/58 (16%)
leucine-rich repeat 605..628 CDD:275380 3/22 (14%)
leucine-rich repeat 629..652 CDD:275380 2/22 (9%)
LRR_8 652..711 CDD:290566 8/66 (12%)
leucine-rich repeat 653..676 CDD:275380 4/22 (18%)
leucine-rich repeat 677..700 CDD:275380 3/29 (10%)
leucine-rich repeat 701..748 CDD:275380 8/47 (17%)
leucine-rich repeat 725..736 CDD:275378 2/10 (20%)
leucine-rich repeat 749..772 CDD:275380 9/42 (21%)
LRR_8 771..831 CDD:290566 17/86 (20%)
leucine-rich repeat 773..793 CDD:275380 9/32 (28%)
LRR_RI 804..1076 CDD:238064 73/292 (25%)
LRR_8 821..903 CDD:290566 23/83 (28%)
leucine-rich repeat 821..844 CDD:275380 6/24 (25%)
leucine-rich repeat 845..868 CDD:275380 6/22 (27%)
leucine-rich repeat 869..892 CDD:275380 10/22 (45%)
leucine-rich repeat 893..915 CDD:275380 3/31 (10%)
leucine-rich repeat 916..944 CDD:275380 11/32 (34%)
leucine-rich repeat 945..968 CDD:275380 4/24 (17%)
LRR_8 967..1027 CDD:290566 21/61 (34%)
leucine-rich repeat 969..992 CDD:275380 4/24 (17%)
leucine-rich repeat 993..1014 CDD:275380 8/20 (40%)
LRR_8 1015..1075 CDD:290566 12/59 (20%)
leucine-rich repeat 1017..1040 CDD:275380 6/22 (27%)
leucine-rich repeat 1041..1064 CDD:275380 2/22 (9%)
LRR_RI <1047..1244 CDD:238064 40/196 (20%)
LRR_8 1063..1125 CDD:290566 15/61 (25%)
leucine-rich repeat 1089..1114 CDD:275380 6/24 (25%)
leucine-rich repeat 1115..1162 CDD:275380 6/46 (13%)
LRR_8 1163..1219 CDD:290566 13/55 (24%)
leucine-rich repeat 1163..1186 CDD:275380 6/22 (27%)
leucine-rich repeat 1187..1210 CDD:275380 3/22 (14%)
leucine-rich repeat 1211..1233 CDD:275380 8/21 (38%)
leucine-rich repeat 1234..1257 CDD:275380 6/22 (27%)
LRR_8 1235..1292 CDD:290566 10/56 (18%)
leucine-rich repeat 1258..1279 CDD:275380 2/20 (10%)
leucine-rich repeat 1282..1306 CDD:275380 4/17 (24%)
Lrrc8dNP_001116240.1 Pannexin_like 1..385 CDD:403656 74/512 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 110..138 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 222..252 5/41 (12%)
inl_like_NEAT_1 <457..>703 CDD:411101 76/313 (24%)
LRR 1 515..535 9/20 (45%)
leucine-rich repeat 516..537 CDD:275378 10/30 (33%)
LRR 2 539..560 2/20 (10%)
LRR 3 562..583 10/29 (34%)
leucine-rich repeat 563..590 CDD:275380 13/35 (37%)
LRR 4 590..610 3/19 (16%)
leucine-rich repeat 591..613 CDD:275380 3/21 (14%)
LRR 597..>826 CDD:227223 71/330 (22%)
LRR 5 613..633 4/20 (20%)
leucine-rich repeat 614..629 CDD:275380 3/14 (21%)
LRR 6 637..658 10/22 (45%)
leucine-rich repeat 638..660 CDD:275380 10/23 (43%)
LRR 7 660..681 7/43 (16%)
leucine-rich repeat 661..685 CDD:275380 8/46 (17%)
LRR 8 685..706 4/21 (19%)
leucine-rich repeat 686..708 CDD:275380 5/22 (23%)
LRR 9 708..729 6/23 (26%)
leucine-rich repeat 709..731 CDD:275380 6/24 (25%)
LRR 10 731..752 5/37 (14%)
leucine-rich repeat 732..754 CDD:275380 6/46 (13%)
LRR 11 754..775 9/44 (20%)
leucine-rich repeat 755..777 CDD:275380 9/45 (20%)
LRR 12 777..798 7/21 (33%)
leucine-rich repeat 778..800 CDD:275380 8/21 (38%)
LRR 13 800..821 7/42 (17%)
leucine-rich repeat 801..821 CDD:275380 7/41 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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