DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG42346 and Tlr4

DIOPT Version :10

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_067272.1 Gene:Tlr4 / 21898 MGIID:96824 Length:835 Species:Mus musculus


Alignment Length:710 Identity:173/710 - (24%)
Similarity:291/710 - (40%) Gaps:95/710 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   800 LDLSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFS 864
            :|||.|.|:.|:...|:...:|:.|.|:|..||.||..|:..|.:|.:|.|:.||:...:...||
Mouse    58 IDLSFNPLKILKSYSFSNFSELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFS 122

  Fly   865 NEFPLNSLNLGNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLDIPNLRRLLLSHNNFSYA 929
            ....|.:|......|..||......|..|.:||:..|.::...:... ..||..|:  |.:.||.
Mouse   123 GLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAY-FSNLTNLV--HVDLSYN 184

  Fly   930 GSVGIMAGMLDRLRSLQQLSMS-NCSLGQIPDLLFAKNTNLVRLDLCDNRLTQINRNIFSGLNVF 993
            ....|....|..||...|:::| :.||..| |.:..:....::|    :.||.  |..|:..|:.
Mouse   185 YIQTITVNDLQFLRENPQVNLSLDMSLNPI-DFIQDQAFQGIKL----HELTL--RGNFNSSNIM 242

  Fly   994 KEL----------RLCRNELSDFPHIALYNLSTLESL-DLARNQLASIDFFKLSGTLNLRQLILR 1047
            |..          ||...|..|..::.::..|.:|.| |:      :||.|:|:.|.:....|: 
Mouse   243 KTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIMEGLCDV------TIDEFRLTYTNDFSDDIV- 300

  Fly  1048 DNKITALSGFNAVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVHLSNNRFLQIP--------- 1103
              |...|:..:|::|     ..:|...|..:|.:|...|:::.:..|.....|.:|         
Mouse   301 --KFHCLANVSAMSL-----AGVSIKYLEDVPKHFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTM 358

  Fly  1104 ---SSALSDVSIPRLSWLNLTGNPI--NRIYTVKEERYPYLKELYICQTNLSILTSKDFEAFQAL 1163
               |.:...|::|.||:|:|:.|.:  :...:..:.....|:.|.: ..|.:|:.|.:|...:.|
Mouse   359 NKGSISFKKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDL-SFNGAIIMSANFMGLEEL 422

  Fly  1164 QHL---HLVNNRITRISPGAFKSLTNLLTLDLSVNELEMLPKERLQGLRLLRFLNISHNTLKD-- 1223
            |||   |....|:|..|  ||.||..||.||:|....::.......||..|..|.::.|:.||  
Mouse   423 QHLDFQHSTLKRVTEFS--AFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKMAGNSFKDNT 485

  Fly  1224 LEEFSVDLLEMQTLDLSFNQLDRISKKTFRNLHGLLELFLMGNRMTVLSNDAFRFLRKLHVLDLR 1288
            |.....:...:..||||..||::||...|..||.|..|.:..|.:..|.:..:..|..|..||..
Mouse   486 LSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCS 550

  Fly  1289 KNYFELVPLEPLRPLETNLRTLRLEENPLHCSCDAQKLWEWLRDHRKWSLSMGSGAGRGIGGLTG 1353
            .|..| .....|:....:|....|..|.:.|.|:.||..:|:::.:::.:               
Mouse   551 FNRIE-TSKGILQHFPKSLAFFNLTNNSVACICEHQKFLQWVKEQKQFLV--------------- 599

  Fly  1354 GLGGDSINYLRCEHPTELRGKVFGRMEPQQFCDAPLIPKMAIQDIQPYSVVVSWQSRDHLGLNGF 1418
                 ::..:.|..|.|:...:.     ..|.::.......|..:...||:|       :....|
Mouse   600 -----NVEQMTCATPVEMNTSLV-----LDFNNSTCYMYKTIISVSVVSVIV-------VSTVAF 647

  Fly  1419 EIVYHATGDGLVTAGSPTSRERDSLRDIHDPERQRTRDQARERSRERDRDRERDRERFSI 1478
             ::||.....::.||.......:|:.|.......:..|..|   .|..::.|....||.:
Mouse   648 -LIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVR---NELVKNLEEGVPRFHL 703

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 LRR <301..606 CDD:443914
leucine-rich repeat 303..325 CDD:275380
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380
leucine-rich repeat 399..422 CDD:275380
leucine-rich repeat 462..485 CDD:275380
LRR 486..>736 CDD:443914
leucine-rich repeat 486..509 CDD:275380
leucine-rich repeat 510..533 CDD:275380
leucine-rich repeat 534..556 CDD:275380
leucine-rich repeat 557..580 CDD:275380
leucine-rich repeat 581..604 CDD:275380
leucine-rich repeat 605..628 CDD:275380
PPP1R42 627..860 CDD:455733 22/59 (37%)
leucine-rich repeat 629..652 CDD:275380
leucine-rich repeat 653..676 CDD:275380
leucine-rich repeat 677..700 CDD:275380
leucine-rich repeat 701..748 CDD:275380
leucine-rich repeat 725..736 CDD:275378
leucine-rich repeat 749..772 CDD:275380
leucine-rich repeat 773..793 CDD:275380
leucine-rich repeat 821..844 CDD:275380 10/22 (45%)
leucine-rich repeat 845..868 CDD:275380 7/22 (32%)
LRR 869..1226 CDD:443914 98/387 (25%)
leucine-rich repeat 869..892 CDD:275380 6/22 (27%)
leucine-rich repeat 893..915 CDD:275380 4/21 (19%)
leucine-rich repeat 916..944 CDD:275380 8/27 (30%)
leucine-rich repeat 945..968 CDD:275380 6/23 (26%)
leucine-rich repeat 969..992 CDD:275380 5/22 (23%)
leucine-rich repeat 993..1014 CDD:275380 5/30 (17%)
leucine-rich repeat 1017..1040 CDD:275380 8/23 (35%)
leucine-rich repeat 1041..1064 CDD:275380 5/22 (23%)
leucine-rich repeat 1089..1114 CDD:275380 5/36 (14%)
leucine-rich repeat 1115..1162 CDD:275380 11/48 (23%)
PPP1R42 1155..1317 CDD:455733 51/166 (31%)
leucine-rich repeat 1163..1186 CDD:275380 12/25 (48%)
leucine-rich repeat 1187..1210 CDD:275380 7/22 (32%)
leucine-rich repeat 1211..1233 CDD:275380 6/23 (26%)
leucine-rich repeat 1234..1257 CDD:275380 10/22 (45%)
leucine-rich repeat 1258..1279 CDD:275380 4/20 (20%)
leucine-rich repeat 1282..1306 CDD:275380 6/23 (26%)
Tlr4NP_067272.1 LRR <53..298 CDD:443914 70/255 (27%)
LRR 1. /evidence=ECO:0000255 54..75 7/16 (44%)
leucine-rich repeat 58..78 CDD:275380 7/19 (37%)
LRR 2. /evidence=ECO:0000255 78..99 9/20 (45%)
leucine-rich repeat 79..102 CDD:275380 10/22 (45%)
LRR 3. /evidence=ECO:0000255 102..123 6/20 (30%)
leucine-rich repeat 103..126 CDD:275380 7/22 (32%)
LRR 4. /evidence=ECO:0000255 126..147 5/20 (25%)
leucine-rich repeat 127..150 CDD:275380 6/22 (27%)
LRR 5. /evidence=ECO:0000255 150..171 4/21 (19%)
leucine-rich repeat 151..175 CDD:275380 6/24 (25%)
LRR 6. /evidence=ECO:0000255 175..198 6/24 (25%)
leucine-rich repeat 176..204 CDD:275380 9/29 (31%)
LRR 7. /evidence=ECO:0000255 204..224 5/20 (25%)
leucine-rich repeat 205..226 CDD:275380 5/21 (24%)
LRR 8. /evidence=ECO:0000255 226..247 7/26 (27%)
LRR 9. /evidence=ECO:0000255 248..269 4/20 (20%)
LRR 10. /evidence=ECO:0000255 329..349 3/19 (16%)
leucine-rich repeat 331..350 CDD:275380 3/18 (17%)
LRR <347..>580 CDD:443914 65/236 (28%)
LRR 11. /evidence=ECO:0000255 350..370 2/19 (11%)
leucine-rich repeat 351..372 CDD:275380 2/20 (10%)
LRR 12. /evidence=ECO:0000255 372..392 5/19 (26%)
leucine-rich repeat 373..398 CDD:275380 5/24 (21%)
LRR 13. /evidence=ECO:0000255 398..420 6/22 (27%)
leucine-rich repeat 399..421 CDD:275380 6/22 (27%)
LRR 14. /evidence=ECO:0000255 421..442 9/22 (41%)
leucine-rich repeat 422..446 CDD:275380 12/25 (48%)
LRR 15. /evidence=ECO:0000255 446..467 5/20 (25%)
leucine-rich repeat 447..470 CDD:275380 7/22 (32%)
LRR 16. /evidence=ECO:0000255 470..490 6/19 (32%)
leucine-rich repeat 471..495 CDD:275380 6/23 (26%)
LRR 17. /evidence=ECO:0000255 495..516 9/20 (45%)
leucine-rich repeat 496..519 CDD:275380 10/22 (45%)
LRR 18. /evidence=ECO:0000255 519..540 4/20 (20%)
leucine-rich repeat 520..543 CDD:275380 5/22 (23%)
LRR 19. /evidence=ECO:0000255 543..564 6/21 (29%)
Interaction with SCIMP. /evidence=ECO:0000269|PubMed:28098138 670..835 8/37 (22%)
TIR 672..813 CDD:214587 7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

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