DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and dma-1

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	NP_492253.1	Gene:	dma-1 / 187968	WormBaseID:	WBGene00011345	Length:	603	Species:	Caenorhabditis elegans

Alignment Length:	472	Identity:	117/472 - (24%)
Similarity:	186/472 - (39%)	Gaps:	85/472 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   953 CSLGQIPDLLFAKNTNLVRLDL-------CDNRLTQINRNIFSGLNVFKELRLCRNELSDFPHIA 1010
            |....|.|.::|:..|.:.|.|       ..||:..........:|.|.:||:.|......|.::
Worm    41 CRKAIINDTIYAEILNQLPLTLRSLHIQPPSNRIGSNKLRWNDNINRFAQLRVLRLINCQIPAMS 105

  Fly  1011 -LYNLSTLESLDLARNQLASIDFFKLSGTLNLRQLILRDNKITALSGFNAVNLTQLDSVDLSGNL 1074
             ...|.:||.|||..|.:.........|...||.|.|..|.:..|.......|..|.|:.||.|.
Worm   106 RSIRLPSLEVLDLHSNNIEHATMSNFGGMPKLRVLDLSSNHLNILPTGVFTYLRALRSLSLSNNT 170

  Fly  1075 LLSLPANFLRHSINLQKVHLSNNRFLQIPSSALSDV--SIPRLSWLNLTGNPINRIYTVKEERYP 1137
            :..|..|.||...:|:.:.|..|   .||...::::  .:.:|..|.|....::.||::..:|.|
Worm   171 ISDLSTNLLRGLNSLRVLRLDRN---PIPIEHINELFTDVSQLDELYLNHCNLSSIYSLALDRIP 232

  Fly  1138 YLKELYICQTNLSILTSKDFEAFQALQHLHLVNNRITRISPGAFKSLTNLLTLDLSVNEL----- 1197
            .|::|.|...||.::.:|:..:...|..|.|.:|.|..|:..||.: ||:..||||.|.|
Worm   233 QLRQLGIGGNNLKMVPTKELRSLPQLSVLDLSHNSIQEITACAFCN-TNISKLDLSHNLLGISKD 296

  Fly  1198 --------EMLPKERLQGLRLLRFLNISHNTLKDL--------------------------EEFS 1228
                    ..:|         ||.|::|.|.:.|.                          |.::
Worm   297 SPFNEDAFRTMP---------LRHLDLSFNHMNDFDSKWLGWAQEELTSIALSGNFLKNFEESWT 352

  Fly  1229 VDLLEMQTLDLSFNQLDRISKKTFRNLHGLLELFLMGNRMTVLSNDAFRFLRKLHVLDLRKNYFE 1293
            ..|..:..|:|::|.:..|..:.....:.|:.|.:.||.:|.|.::....|..:...|:..|.|.
Worm   353 YTLKSLIHLELAYNHIKFIPVQLPSRYYHLISLNISGNELTYLPDNINTLLPNVKTFDITANRFH 417

  Fly  1294 LVPLEPLRPLETNLRTLRLEENPLHCSCDAQKLWEWLRDHRKWSLSMGSGAGRGIGGLTGGLGGD 1358
            ......|..| .|:..:.::.||..|||..|.|...:||..         |.|.|
Worm   418 TFSHTDLAFL-NNVEQVYVDGNPWDCSCAIQGLQVHMRDRY---------AMRHI---------- 462

  Fly  1359 SINY--LRCEHPTELRG 1373
             :||  :||..|:.:.|
Worm   463 -LNYDNVRCATPSLVEG 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380
		LRR_8	325..384	CDD:290566
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		LRR_8	373..433	CDD:290566
		LRR_RI	397..648	CDD:238064
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR_8	465..520	CDD:290566
		leucine-rich repeat	486..509	CDD:275380
		LRR_8	508..567	CDD:290566
		leucine-rich repeat	510..533	CDD:275380
		LRR_RI	527..785	CDD:238064
		leucine-rich repeat	534..556	CDD:275380
		LRR_8	555..613	CDD:290566
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		LRR_8	604..663	CDD:290566
		leucine-rich repeat	605..628	CDD:275380
		leucine-rich repeat	629..652	CDD:275380
		LRR_8	652..711	CDD:290566
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		LRR_8	771..831	CDD:290566
		leucine-rich repeat	773..793	CDD:275380
		LRR_RI	804..1076	CDD:238064	35/130 (27%)
		LRR_8	821..903	CDD:290566
		leucine-rich repeat	821..844	CDD:275380
		leucine-rich repeat	845..868	CDD:275380
		leucine-rich repeat	869..892	CDD:275380
		leucine-rich repeat	893..915	CDD:275380
		leucine-rich repeat	916..944	CDD:275380
		leucine-rich repeat	945..968	CDD:275380	4/14 (29%)
		LRR_8	967..1027	CDD:290566	18/67 (27%)
		leucine-rich repeat	969..992	CDD:275380	4/29 (14%)
		leucine-rich repeat	993..1014	CDD:275380	5/21 (24%)
		LRR_8	1015..1075	CDD:290566	19/59 (32%)
		leucine-rich repeat	1017..1040	CDD:275380	7/22 (32%)
		leucine-rich repeat	1041..1064	CDD:275380	7/22 (32%)
		LRR_RI	<1047..1244	CDD:238064	58/237 (24%)
		LRR_8	1063..1125	CDD:290566	17/63 (27%)
		leucine-rich repeat	1089..1114	CDD:275380	5/26 (19%)
		leucine-rich repeat	1115..1162	CDD:275380	13/46 (28%)
		LRR_8	1163..1219	CDD:290566	21/68 (31%)
		leucine-rich repeat	1163..1186	CDD:275380	8/22 (36%)
		leucine-rich repeat	1187..1210	CDD:275380	7/35 (20%)
		leucine-rich repeat	1211..1233	CDD:275380	8/47 (17%)
		leucine-rich repeat	1234..1257	CDD:275380	4/22 (18%)
		LRR_8	1235..1292	CDD:290566	13/56 (23%)
		leucine-rich repeat	1258..1279	CDD:275380	6/20 (30%)
		leucine-rich repeat	1282..1306	CDD:275380	5/23 (22%)
dma-1	NP_492253.1	LRR_8	90..147	CDD:338972	17/56 (30%)
		leucine-rich repeat	91..112	CDD:275380	5/20 (25%)
		leucine-rich repeat	113..136	CDD:275380	7/22 (32%)
		LRR	136..430	CDD:227223	75/307 (24%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		leucine-rich repeat	161..184	CDD:275380	9/22 (41%)
		leucine-rich repeat	185..209	CDD:275380	5/26 (19%)
		leucine-rich repeat	210..233	CDD:275380	6/22 (27%)
		leucine-rich repeat	234..257	CDD:275380	6/22 (27%)
		leucine-rich repeat	258..280	CDD:275380	8/22 (36%)
		leucine-rich repeat	281..307	CDD:275380	6/25 (24%)
		leucine-rich repeat	309..357	CDD:275380	8/47 (17%)
		leucine-rich repeat	382..405	CDD:275380	7/22 (32%)
		leucine-rich repeat	406..429	CDD:275380	5/23 (22%)
		TPKR_C2	438..>478	CDD:387596	17/59 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010