Protein Alignment CG42346 and let-4

DIOPT Version :10

• Sequence 1: NP_001036303.2
• Gene: CG42346 / 3355160
• FlyBaseID: FBgn0259677
• Length: 1817
• Species: Drosophila melanogaster
• Sequence 2: NP_510425.2
• Gene: let-4 / 181554
• WormBaseID: WBGene00002282
• Length: 773
• Species: Caenorhabditis elegans
• Alignment Length: 837
• Identity: 202/837 - (24%)
• Similarity: 340/837 - (40%)
• Gaps: 196/837 - (23%)

  Fly   919 LLLSHNNFSYAGSVGIMAGMLDRLRSLQQLSMSNCSLGQIPDLLFAKNTNLVRLDLCDNRLTQIN 983
            ::|..:|.|.:|.:.|:.....::..:|.|:|:...|.::|...|: ...:.||||..|::.:|:
 Worm    38 IVLDCSNSSASGILQIIRTNQAQVGLIQSLTMNQAELVELPPNFFS-GLFIRRLDLSQNKIKKID 101

  Fly   984 RNIFSGLN-VFKELRLCRNELSDFPHIALYNLSTLESLDLARNQLASIDFFKLSGTLN-LRQLIL 1046
            ...|:|:| |.:|:.|..|.:...|..||..|..|..|||:.|.:..|...::...|| |..:.|
 Worm   102 DAAFAGINPVLEEVVLNHNLIEKVPAAALAGLPNLLRLDLSNNSIVEIQEQEIFPNLNKLYDINL 166

  Fly  1047 RDNKITAL--SGFNAVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVHLSNNRFLQIPSSALSD 1109
            ..|||.::  |.|..|. ..:.:::|..|.:.::|::.:|....||.:||..||..|:  .||:.
 Worm   167 GSNKIFSIHTSTFQNVK-NSIQTINLGHNNMTAVPSSAIRGLKQLQSLHLHKNRIEQL--DALNF 228

  Fly  1110 VSIPRLSWLNLTGNPINRIYTVKEERYPYLKELYICQTNLSILTSKDFEAFQALQHLHLVNNRIT 1174
            :::|.|:.|||.||.|:.                        |..:.|....:|::|:|..|:||
 Worm   229 LNLPVLNLLNLAGNQIHE------------------------LNRQAFLNVPSLRYLYLSGNKIT 269

  Fly  1175 RISPGAFKSLTNLLTLDLSVNELEMLPKERLQGLRLLRFLNISHNTLKDLE-----EFSVDLL-- 1232
            :::...|::...|..|||:.||:..:|...|.||:.||.|.::||.:.::.     ..|:.:|
 Worm   270 KLTAYQFQTFEQLEMLDLTNNEIGAIPANSLSGLKQLRQLYLAHNKISNISSNAFTNSSIVVLVL 334

  Fly  1233 ---EMQTL------------DLSF--NQLDRISKKTFRNLHGLLELFLMGNRMTVLSNDAFRFLR 1280
               |::||            .:||  ||:..|::..|.:...|:.|.|..|::|.::...|....
 Worm   335 SSNELKTLTAGIISGLPNLQQVSFRDNQIKTINRNAFYDAASLVMLDLAKNQLTEIAPTTFLAQL 399

  Fly  1281 KLHVLDLRKNYFELVPLEPLRPLETNLRTLRLEENPLHCSCDAQKLWEWLRDHRKWSLSMGSGAG 1345
            .|.::||.:|   .:|..|.....:.:.|:.|:||||.|:.:...|.:                |
 Worm   400 NLLLVDLSEN---KLPKTPYSAFNSRVGTVLLKENPLVCTENLHMLQQ----------------G 445

  Fly  1346 RGIGGLTGGLGGDSINYLRCEHPTELRG-KVFGRMEPQQFCDAPLIPKMAIQDIQPYSVVVSWQS 1409
            .|:             |:| :.|..:.| |...:.||..   .|::....|...:|..|.:. :.
 Worm   446 TGV-------------YVR-DSPDIICGRKPTPKPEPVL---VPIVTDSLISTQRPALVQIP-KM 492

  Fly  1410 RDHLGLNGFEIVYHATGDGL----------VTAGSPTSRERDSLRDIHDPERQRTRDQARERSRE 1464
            :.|..      |:..|||..          :..|...|..|...|.|.|  :..||:|:.|.:.|
 Worm   493 QIHRN------VHTTTGDQAPQIPSGAFQQIDLGKSRSLPRGHSRFILD--KPSTREQSVEPTEE 549

  Fly  1465 RD-------RDRERDRERFSIATDEIHGKRLNGTASSTKLTKLSPNTRYHICVIGSGN-WLSEPL 1521
            ..       ..||          |||....:....|...:...|........:|...| .|..|:
 Worm   550 LTPIQPIILPSRE----------DEIRQSSMEAGTSQESVEATSQKIPSTTDIIDRPNVVLPFPV 604

  Fly  1522 ANALQRLHTNESLREEEAVMMSA-----PLPES--FSPYQHQHNRNSNGNANPAMVQDHNKKQNP 1579
            ....:..:.:||.:.|...|.|.     .||.|  ..|           .:.|.:.|       |
 Worm   605 PFLKRGPNLSESKKVESTDMPSTSQVFHTLPPSILIEP-----------GSTPKVAQ-------P 651

  Fly  1580 DQDLDNVVGQDNALMEVLKNSHISACTDVQTLDSTPSLVTDENGLSSNGFIHSILTRRL------ 1638
            ..:.:            :|:.||                 ||..|:|:......|..||
 Worm   652 STEAN------------IKSEHI-----------------DEFALASSNSNEPTLQPRLEKSFFT 687

  Fly  1639 GLIVGCCLG--IIVFIVMISVLSYVKLKKKRIEN--AKRQAALPPEYIS--YRHFSI 1689
            ..|:..|:|  :||.:|:|:.|...|.::.:.||  :...||...||||  ||..|:
 Worm   688 TTIIFICVGTAVIVLVVVIAGLCISKHRQLQFENTYSDSSAARTSEYISTQYRQNSL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	LRR	<301..606	CDD:443914
		leucine-rich repeat	303..325	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR	486..>736	CDD:443914
		leucine-rich repeat	486..509	CDD:275380
		leucine-rich repeat	510..533	CDD:275380
		leucine-rich repeat	534..556	CDD:275380
		leucine-rich repeat	557..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..628	CDD:275380
		PPP1R42	627..860	CDD:455733
		leucine-rich repeat	629..652	CDD:275380
		leucine-rich repeat	653..676	CDD:275380
		leucine-rich repeat	677..700	CDD:275380
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		leucine-rich repeat	773..793	CDD:275380
		leucine-rich repeat	821..844	CDD:275380
		leucine-rich repeat	845..868	CDD:275380
		LRR	869..1226	CDD:443914	89/315 (28%)
		leucine-rich repeat	869..892	CDD:275380
		leucine-rich repeat	893..915	CDD:275380
		leucine-rich repeat	916..944	CDD:275380	5/24 (21%)
		leucine-rich repeat	945..968	CDD:275380	6/22 (27%)
		leucine-rich repeat	969..992	CDD:275380	9/23 (39%)
		leucine-rich repeat	993..1014	CDD:275380	6/20 (30%)
		leucine-rich repeat	1017..1040	CDD:275380	6/22 (27%)
		leucine-rich repeat	1041..1064	CDD:275380	8/24 (33%)
		leucine-rich repeat	1089..1114	CDD:275380	9/24 (38%)
		leucine-rich repeat	1115..1162	CDD:275380	9/46 (20%)
		PPP1R42	1155..1317	CDD:455733	50/185 (27%)
		leucine-rich repeat	1163..1186	CDD:275380	7/22 (32%)
		leucine-rich repeat	1187..1210	CDD:275380	10/22 (45%)
		leucine-rich repeat	1211..1233	CDD:275380	7/31 (23%)
		leucine-rich repeat	1234..1257	CDD:275380	8/36 (22%)
		leucine-rich repeat	1258..1279	CDD:275380	6/20 (30%)
		leucine-rich repeat	1282..1306	CDD:275380	6/23 (26%)
let-4	NP_510425.2	leucine-rich repeat	66..86	CDD:275380	5/20 (25%)
		LRR	85..414	CDD:443914	100/358 (28%)
		leucine-rich repeat	88..111	CDD:275380	9/22 (41%)
		leucine-rich repeat	112..135	CDD:275380	7/22 (32%)
		leucine-rich repeat	136..160	CDD:275380	7/23 (30%)
		leucine-rich repeat	161..184	CDD:275380	8/23 (35%)
		leucine-rich repeat	186..209	CDD:275380	4/22 (18%)
		leucine-rich repeat	210..257	CDD:275380	19/72 (26%)
		leucine-rich repeat	258..281	CDD:275380	7/22 (32%)
		leucine-rich repeat	282..305	CDD:275380	10/22 (45%)
		leucine-rich repeat	306..328	CDD:275380	5/21 (24%)
		leucine-rich repeat	329..350	CDD:275380	4/20 (20%)
		leucine-rich repeat	353..400	CDD:275380	12/46 (26%)
		leucine-rich repeat	356..376	CDD:275380	6/19 (32%)
		leucine-rich repeat	401..419	CDD:275380	6/20 (30%)