DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and Igfals

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_001351825.1 Gene:Igfals / 16005 MGIID:107973 Length:638 Species:Mus musculus


Alignment Length:673 Identity:183/673 - (27%)
Similarity:274/673 - (40%) Gaps:112/673 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   487 KTLSFYANQIELVQPEA-FKSLRELMSL-----DMSHNRIIGLDPKVFEKNKRLQ---TVDLSHN 542
            |.|...||.:.|.:|.| ::....|:.|     .:....:.|.||......:..|   |...|::
Mouse    21 KALGNRANCLSLTEPSAPYRGSPALVVLLAFWVALGPCYLQGTDPGASADAEGPQCPVTCTCSYD 85

  Fly   543 HIHTIGGVF---SNLPQL--------REVFLSENNILELPADAFTNSTNVDVIYLESNAIAHIDP 596
            .......||   .||.||        |.::|..||:..:|:.||.|.:::|.:.|:.:.:..::|
Mouse    86 DYTDELSVFCSSRNLTQLPDSIPVSTRALWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEP 150

  Fly   597 NVFSTLVNLDHLYLRSNFIPLLPVTLFDKSTKLTSLSLDNNEIQDLEIGMFRKLEHLREVRLHNN 661
            .....|.||.||:|..|.:..|...||..:..|.||||.||.:..||.|:||.|.|         
Mouse   151 QALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRLEEGLFRGLSH--------- 206

  Fly   662 RIRRVRRGVFEPLPSLQELHIQKNSIEDIEPQAFHTLENMQHINLQDNQLTVLEDIFPDENSSLL 726
                           |.:|::..||:..:....|..|.|:..:.|..|:||.|:.........|.
Mouse   207 ---------------LWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLGELR 256

  Fly   727 SVQLEANYLHKVHPRTFSRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYLSDNKIRDIEKDTF 791
            .:.|..|.|..|....|....::|.::|..|.:|.|....|.....|..|.||.|::..:.:|||
Mouse   257 ELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTF 321

  Fly   792 VNLLLLQFLDLSGNQLRQLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLV 856
            ..||.|..|.|:.|.:..||...|..|..||||.|..|.|..:....|..|..|:.|.|:.|.:.
Mouse   322 PGLLGLHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIRQLGEKTFEGLGQLEVLTLNDNQIH 386

  Fly   857 QLTRDIFSNEFPLNSLNL-GNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTL-DIPNLRRL 919
            ::....|...|.:..:|| ||| ||.|.:|.|:.|..|:.|:||.:.|....:.|. .:..||||
Mouse   387 EVKVGAFFGLFNVAVMNLSGNC-LRSLPEHVFQGLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRL 450

  Fly   920 LLSHNNFSYAGSVGIMAGMLDRLRSLQQLSMSNCSLGQIPDLLFAKNTNLVRLDLCDNRLTQINR 984
            .|..|:.|                |:::.|::..|             .|:.|||..|:||.:.|
Mouse   451 FLRDNSIS----------------SIEEQSLAGLS-------------ELLELDLTANQLTHLPR 486

  Fly   985 NIFSGLNVFKELRLCRNELSDFPHIALYNLSTLESLDLARNQLASIDFFKLSGTLNLRQLILRDN 1049
            .:|.||...:.|.|..|:|:......|..|.....|||:.|:|.:......|....||.|.||:|
Mouse   487 QLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLETPAEGLFSSLGRLRYLNLRNN 551

  Fly  1050 KITALSGFNAVNLTQLDSVDLSGNLLLSLPANFLRHSINLQKVHLSNNRF-LQIPSSALSDVS-- 1111
            .:...             |...|                |:::.|..|.: ...|..||.|.:  
Mouse   552 SLQTF-------------VPQPG----------------LERLWLDANPWDCSCPLKALRDFALQ 587

  Fly  1112 ----IPRLSWLNLTGNPINRIYT 1130
                :||.......|:....:||
Mouse   588 NPGVVPRFVQTVCEGDDCQPVYT 610

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380
LRR_8 325..384 CDD:290566
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380
LRR_8 373..433 CDD:290566
LRR_RI 397..648 CDD:238064 52/180 (29%)
leucine-rich repeat 399..422 CDD:275380
leucine-rich repeat 462..485 CDD:275380
LRR_8 465..520 CDD:290566 9/38 (24%)
leucine-rich repeat 486..509 CDD:275380 7/22 (32%)
LRR_8 508..567 CDD:290566 17/77 (22%)
leucine-rich repeat 510..533 CDD:275380 5/27 (19%)
LRR_RI 527..785 CDD:238064 73/271 (27%)
leucine-rich repeat 534..556 CDD:275380 7/27 (26%)
LRR_8 555..613 CDD:290566 19/65 (29%)
leucine-rich repeat 557..580 CDD:275380 9/30 (30%)
leucine-rich repeat 581..604 CDD:275380 4/22 (18%)
LRR_8 604..663 CDD:290566 23/58 (40%)
leucine-rich repeat 605..628 CDD:275380 8/22 (36%)
leucine-rich repeat 629..652 CDD:275380 13/22 (59%)
LRR_8 652..711 CDD:290566 10/58 (17%)
leucine-rich repeat 653..676 CDD:275380 0/22 (0%)
leucine-rich repeat 677..700 CDD:275380 6/22 (27%)
leucine-rich repeat 701..748 CDD:275380 11/46 (24%)
leucine-rich repeat 725..736 CDD:275378 3/10 (30%)
leucine-rich repeat 749..772 CDD:275380 6/22 (27%)
LRR_8 771..831 CDD:290566 24/59 (41%)
leucine-rich repeat 773..793 CDD:275380 8/19 (42%)
LRR_RI 804..1076 CDD:238064 78/273 (29%)
LRR_8 821..903 CDD:290566 30/82 (37%)
leucine-rich repeat 821..844 CDD:275380 9/22 (41%)
leucine-rich repeat 845..868 CDD:275380 5/22 (23%)
leucine-rich repeat 869..892 CDD:275380 11/23 (48%)
leucine-rich repeat 893..915 CDD:275380 6/22 (27%)
leucine-rich repeat 916..944 CDD:275380 7/27 (26%)
leucine-rich repeat 945..968 CDD:275380 2/22 (9%)
LRR_8 967..1027 CDD:290566 21/59 (36%)
leucine-rich repeat 969..992 CDD:275380 11/22 (50%)
leucine-rich repeat 993..1014 CDD:275380 5/20 (25%)
LRR_8 1015..1075 CDD:290566 14/59 (24%)
leucine-rich repeat 1017..1040 CDD:275380 6/22 (27%)
leucine-rich repeat 1041..1064 CDD:275380 6/22 (27%)
LRR_RI <1047..1244 CDD:238064 16/91 (18%)
LRR_8 1063..1125 CDD:290566 12/68 (18%)
leucine-rich repeat 1089..1114 CDD:275380 7/31 (23%)
leucine-rich repeat 1115..1162 CDD:275380 3/16 (19%)
LRR_8 1163..1219 CDD:290566
leucine-rich repeat 1163..1186 CDD:275380
leucine-rich repeat 1187..1210 CDD:275380
leucine-rich repeat 1211..1233 CDD:275380
leucine-rich repeat 1234..1257 CDD:275380
LRR_8 1235..1292 CDD:290566
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
IgfalsNP_001351825.1 LRRNT 75..113 CDD:214470 9/37 (24%)
leucine-rich repeat 92..110 CDD:275380 6/17 (35%)
PLN00113 96..>558 CDD:331614 152/528 (29%)
leucine-rich repeat 114..134 CDD:275380 7/19 (37%)
leucine-rich repeat 135..158 CDD:275380 4/22 (18%)
leucine-rich repeat 159..182 CDD:275380 8/22 (36%)
leucine-rich repeat 183..206 CDD:275380 13/22 (59%)
leucine-rich repeat 207..230 CDD:275380 6/22 (27%)
leucine-rich repeat 231..254 CDD:275380 5/22 (23%)
leucine-rich repeat 255..278 CDD:275380 6/22 (27%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 8/22 (36%)
leucine-rich repeat 351..374 CDD:275380 9/22 (41%)
leucine-rich repeat 375..396 CDD:275380 5/20 (25%)
leucine-rich repeat 423..446 CDD:275380 6/22 (27%)
leucine-rich repeat 447..470 CDD:275380 10/51 (20%)
leucine-rich repeat 471..494 CDD:275380 11/22 (50%)
leucine-rich repeat 495..516 CDD:275380 5/20 (25%)
leucine-rich repeat 519..542 CDD:275380 6/22 (27%)
leucine-rich repeat 543..561 CDD:275380 7/30 (23%)
TPKR_C2 570..613 CDD:326558 10/41 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm42484
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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