DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and STK11IP

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_443134.3 Gene:STK11IP / 114790 HGNCID:19184 Length:1088 Species:Homo sapiens


Alignment Length:552 Identity:128/552 - (23%)
Similarity:201/552 - (36%) Gaps:164/552 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1033 FKLSGTLNLRQLILRDNKITALSGFNAVN-----LTQLDSV-----------------------D 1069
            :||:|       :||::....|||.:.::     |.||:.|                       |
Human    11 WKLAG-------LLRESGDVVLSGCSTLSLLTPTLQQLNHVFELHLGPWGPGQTGFVALPSHPAD 68

  Fly  1070 LSGNLLLSLPANFLRHSINLQKVHLSNNRFLQIPSSALSDVSIPRLSWLNLTGNPINRIYTVKEE 1134
            ....|.|....:.|:.:::|:.||::...    |:..:.......|..|.|.|.|::.::.:: .
Human    69 SPVILQLQFLFDVLQKTLSLKLVHVAGPG----PTGPIKIFPFKSLRHLELRGVPLHCLHGLR-G 128

  Fly  1135 RYPYLKELYICQTNLSILTSKDFEAFQALQHLHLVNNRITRISPGAFKSL---TNLLTLDLSVNE 1196
            .|..|:.| ||..:|           |||:.|       .....|.|.|.   ..||:.:.|.|.
Human   129 IYSQLETL-ICSRSL-----------QALEEL-------LSACGGDFCSALPWLALLSANFSYNA 174

  Fly  1197 LEMLPKERLQGLRLLRFLNISHNTLKDLEEFSVDLLEMQTLDLSFNQLDRISK------------ 1249
            |..|... |:.|..|||||:|||.::|.:.|.:||.|:..||:|:|:|..:.:            
Human   175 LTALDSS-LRLLSALRFLNLSHNQVQDCQGFLMDLCELHHLDISYNRLHLVPRMGPSGAALGVLI 238

  Fly  1250 ---KTFRNLHGLLELFLMGNRMTVLSNDAFRFLRKLHVLDLRKN----YFELVPLEPLRPLETNL 1307
               ...|:||||.:                  ||.|..|||..|    :.||.||.    |...|
Human   239 LRGNELRSLHGLEQ------------------LRNLRHLDLAYNLLEGHRELSPLW----LLAEL 281

  Fly  1308 RTLRLEENPL-----HCSCDAQKLWEWLRD-------------------HRKWSLS-MGSGAGRG 1347
            |.|.||.|||     |.:..||.|....||                   |....|| ||......
Human   282 RKLYLEGNPLWFHPEHRAATAQYLSPRARDAATGFLLDGKVLSLTDFQTHTSLGLSPMGPPLPWP 346

  Fly  1348 IGGLTGGLGG----DSINY-------LRCEHPTELRGKVFGRMEPQQFCDAP--LIPKMAIQDIQ 1399
            :|......||    ||::.       |..:..:.:|.:.....||......|  |.|..|...:|
Human   347 VGSTPETSGGPDLSDSLSSGGVVTQPLLHKVKSRVRVRRASISEPSDTDPEPRTLNPSPAGWFVQ 411

  Fly  1400 PYSVVVSWQS-RDHLGLNGFEIVYH---------------------ATGDGLVTAGSPTSRERDS 1442
            .:..:....| |:..|.|..:...|                     |:..|..||..|:..:.::
Human   412 QHPELELMSSFRERFGRNWLQYRSHLEPSGNPLPATPTTSAPSAPPASSQGPDTAPRPSPPQEEA 476

  Fly  1443 LRDIHDPERQRTRDQARERSRERDRDRERDRE 1474
            ......|::.....:|..:..|.:::.:.::|
Human   477 RGPQESPQKMSEEVRAEPQEEEEEKEGKEEKE 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380
LRR_8 325..384 CDD:290566
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380
LRR_8 373..433 CDD:290566
LRR_RI 397..648 CDD:238064
leucine-rich repeat 399..422 CDD:275380
leucine-rich repeat 462..485 CDD:275380
LRR_8 465..520 CDD:290566
leucine-rich repeat 486..509 CDD:275380
LRR_8 508..567 CDD:290566
leucine-rich repeat 510..533 CDD:275380
LRR_RI 527..785 CDD:238064
leucine-rich repeat 534..556 CDD:275380
LRR_8 555..613 CDD:290566
leucine-rich repeat 557..580 CDD:275380
leucine-rich repeat 581..604 CDD:275380
LRR_8 604..663 CDD:290566
leucine-rich repeat 605..628 CDD:275380
leucine-rich repeat 629..652 CDD:275380
LRR_8 652..711 CDD:290566
leucine-rich repeat 653..676 CDD:275380
leucine-rich repeat 677..700 CDD:275380
leucine-rich repeat 701..748 CDD:275380
leucine-rich repeat 725..736 CDD:275378
leucine-rich repeat 749..772 CDD:275380
LRR_8 771..831 CDD:290566
leucine-rich repeat 773..793 CDD:275380
LRR_RI 804..1076 CDD:238064 14/70 (20%)
LRR_8 821..903 CDD:290566
leucine-rich repeat 821..844 CDD:275380
leucine-rich repeat 845..868 CDD:275380
leucine-rich repeat 869..892 CDD:275380
leucine-rich repeat 893..915 CDD:275380
leucine-rich repeat 916..944 CDD:275380
leucine-rich repeat 945..968 CDD:275380
LRR_8 967..1027 CDD:290566
leucine-rich repeat 969..992 CDD:275380
leucine-rich repeat 993..1014 CDD:275380
LRR_8 1015..1075 CDD:290566 13/69 (19%)
leucine-rich repeat 1017..1040 CDD:275380 3/6 (50%)
leucine-rich repeat 1041..1064 CDD:275380 6/27 (22%)
LRR_RI <1047..1244 CDD:238064 59/227 (26%)
LRR_8 1063..1125 CDD:290566 15/84 (18%)
leucine-rich repeat 1089..1114 CDD:275380 4/24 (17%)
leucine-rich repeat 1115..1162 CDD:275380 11/46 (24%)
LRR_8 1163..1219 CDD:290566 19/58 (33%)
leucine-rich repeat 1163..1186 CDD:275380 5/25 (20%)
leucine-rich repeat 1187..1210 CDD:275380 8/22 (36%)
leucine-rich repeat 1211..1233 CDD:275380 12/21 (57%)
leucine-rich repeat 1234..1257 CDD:275380 7/37 (19%)
LRR_8 1235..1292 CDD:290566 17/75 (23%)
leucine-rich repeat 1258..1279 CDD:275380 1/20 (5%)
leucine-rich repeat 1282..1306 CDD:275380 10/27 (37%)
STK11IPNP_443134.3 LIP1 4..93 CDD:318176 18/88 (20%)
LRR <101..>301 CDD:227223 70/242 (29%)
LRR 1 109..130 5/21 (24%)
LRR 2 132..152 9/38 (24%)
leucine-rich repeat 160..187 CDD:275380 8/27 (30%)
LRR 3 164..185 7/21 (33%)
LRR 4 187..209 11/21 (52%)
leucine-rich repeat 188..210 CDD:275380 12/21 (57%)
LRR 5 210..231 6/20 (30%)
leucine-rich repeat 211..233 CDD:275380 5/21 (24%)
LRR 6 233..254 5/38 (13%)
leucine-rich repeat 234..255 CDD:275380 6/38 (16%)
LRR 7 255..276 8/20 (40%)
leucine-rich repeat 256..280 CDD:275380 10/27 (37%)
LRR 8 280..301 9/20 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 335..407 16/71 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 437..533 9/72 (13%)
HypA <668..719 CDD:327519
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 724..780
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 978..1009
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S8018
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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