DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42346 and lrrc8a

DIOPT Version :9

Sequence 1:	NP_001036303.2	Gene:	CG42346 / 3355160	FlyBaseID:	FBgn0259677	Length:	1817	Species:	Drosophila melanogaster
Sequence 2:	XP_002935552.1	Gene:	lrrc8a / 100492279	XenbaseID:	XB-GENE-1012024	Length:	809	Species:	Xenopus tropicalis

Alignment Length:	471	Identity:	113/471 - (23%)
Similarity:	203/471 - (43%)	Gaps:	100/471 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 IHSLSIYD------FDRSVTSLSQDVFQPGVHIRHLQFSHS-HLEALKDNSLRNVRSSLE-SLSI 332
            :|.:..||      |...::.:|::      .:|.|..:|. .|:.|:....:|.:..|| .|.:
Frog   375 LHLIDQYDPLYSKRFAVFLSEVSEN------KLRQLNLNHEWTLDKLRQRITKNSQEKLELHLFM 433

  Fly   333 VNG--------------KLTQMPSRAL-SSMQKLTALD--FDYNEIVRVDDYSFYGLR--ISKLN 378
            ::|              ||..:|...: .|:.:||.|.  :.|:...:::..:...||  :..|:
Frog   434 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLKSLH 498

  Fly   379 MKGNRLQGMP--EHAFAGLEECMQEIDVSENGLRTFPLMALRKLDHLRILRLSNN--RIPTFYGD 439
            :|...::.:|  .::...|||.....::|....|...:..||:|..|::|||.:|  ::|....|
Frog   499 IKFTDIKEIPLWIYSLKNLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLTKLPQVVTD 563

  Fly   440 I-----QLATNNASAAAAAVGAFQLPSLIFLDLSSNQFAEIGPDCFRAFPQLKTLSFYANQIELV 499
            :     :|:.||.......:.:  |..::.|                            .::|||
Frog   564 VGVHLQKLSVNNEGTKLMVLNS--LKKMVNL----------------------------TELELV 598

  Fly   500 Q------PEAFKSLRELMSLDMSHNRIIGLDPKV-FEKNKRLQTVDLSHNHIHTIGGVFSNLPQL 557
            :      |.:..||..|..:|:..|.:..::..: |:...||..:.|.:|||..|.....||..|
Frog   599 RCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLASL 663

  Fly   558 REVFLSENNILELPADAF--TNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRSNFIPLLPV 620
            ..::|:.|.|.::|...|  ....::|   |..|:::.|.|.: ..|.:|.:|.:.:|.|..||.
Frog   664 ERLYLNRNKIEKIPTQLFLCRKLRHLD---LSHNSLSSIPPEI-GHLQSLQYLAVTANHIENLPA 724

  Fly   621 TLFDKSTKLTSLSLDNNEIQDL--EIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLP-SLQELHI 682
            .|| ...||.:|:|.||.:|.|  .:|   :|.:|.:|.|..||:        |.|| .|.:.|:
Frog   725 ELF-LCKKLRTLNLGNNVLQSLPSRVG---ELTNLSQVELRGNRL--------EYLPVELGDCHL 777

  Fly   683 QKNSIEDIEPQAFHTL 698
            .|.|...:|...|:||
Frog   778 LKRSGLVVEEDLFNTL 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	leucine-rich repeat	303..325	CDD:275380	6/22 (27%)
		LRR_8	325..384	CDD:290566	16/78 (21%)
		leucine-rich repeat	327..350	CDD:275380	8/38 (21%)
		leucine-rich repeat	351..461	CDD:275380	28/122 (23%)
		LRR_8	373..433	CDD:290566	17/65 (26%)
		LRR_RI	397..648	CDD:238064	66/268 (25%)
		leucine-rich repeat	399..422	CDD:275380	5/22 (23%)
		leucine-rich repeat	462..485	CDD:275380	1/22 (5%)
		LRR_8	465..520	CDD:290566	10/60 (17%)
		leucine-rich repeat	486..509	CDD:275380	6/28 (21%)
		LRR_8	508..567	CDD:290566	16/59 (27%)
		leucine-rich repeat	510..533	CDD:275380	4/23 (17%)
		LRR_RI	527..785	CDD:238064	56/178 (31%)
		leucine-rich repeat	534..556	CDD:275380	8/21 (38%)
		LRR_8	555..613	CDD:290566	14/59 (24%)
		leucine-rich repeat	557..580	CDD:275380	6/24 (25%)
		leucine-rich repeat	581..604	CDD:275380	6/22 (27%)
		LRR_8	604..663	CDD:290566	22/60 (37%)
		leucine-rich repeat	605..628	CDD:275380	8/22 (36%)
		leucine-rich repeat	629..652	CDD:275380	9/24 (38%)
		LRR_8	652..711	CDD:290566	16/48 (33%)
		leucine-rich repeat	653..676	CDD:275380	8/23 (35%)
		leucine-rich repeat	677..700	CDD:275380	8/22 (36%)
		leucine-rich repeat	701..748	CDD:275380
		leucine-rich repeat	725..736	CDD:275378
		leucine-rich repeat	749..772	CDD:275380
		LRR_8	771..831	CDD:290566
		leucine-rich repeat	773..793	CDD:275380
		LRR_RI	804..1076	CDD:238064
		LRR_8	821..903	CDD:290566
		leucine-rich repeat	821..844	CDD:275380
		leucine-rich repeat	845..868	CDD:275380
		leucine-rich repeat	869..892	CDD:275380
		leucine-rich repeat	893..915	CDD:275380
		leucine-rich repeat	916..944	CDD:275380
		leucine-rich repeat	945..968	CDD:275380
		LRR_8	967..1027	CDD:290566
		leucine-rich repeat	969..992	CDD:275380
		leucine-rich repeat	993..1014	CDD:275380
		LRR_8	1015..1075	CDD:290566
		leucine-rich repeat	1017..1040	CDD:275380
		leucine-rich repeat	1041..1064	CDD:275380
		LRR_RI	<1047..1244	CDD:238064
		LRR_8	1063..1125	CDD:290566
		leucine-rich repeat	1089..1114	CDD:275380
		leucine-rich repeat	1115..1162	CDD:275380
		LRR_8	1163..1219	CDD:290566
		leucine-rich repeat	1163..1186	CDD:275380
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		LRR_8	1235..1292	CDD:290566
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
lrrc8a	XP_002935552.1	Pannexin_like	1..339	CDD:372171
		leucine-rich repeat	425..446	CDD:275380	4/20 (20%)
		PLN00113	<434..>773	CDD:215061	91/384 (24%)
		leucine-rich repeat	447..469	CDD:275380	5/21 (24%)
		leucine-rich repeat	470..493	CDD:275380	4/22 (18%)
		leucine-rich repeat	494..516	CDD:275380	3/21 (14%)
		leucine-rich repeat	517..544	CDD:275380	8/26 (31%)
		leucine-rich repeat	592..614	CDD:275380	7/49 (14%)
		leucine-rich repeat	615..639	CDD:275380	4/23 (17%)
		leucine-rich repeat	640..662	CDD:275380	8/21 (38%)
		leucine-rich repeat	663..685	CDD:275380	6/21 (29%)
		leucine-rich repeat	686..708	CDD:275380	6/25 (24%)
		leucine-rich repeat	709..731	CDD:275380	8/22 (36%)
		leucine-rich repeat	732..754	CDD:275380	9/24 (38%)
		leucine-rich repeat	755..775	CDD:275380	9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000